Septolete Total - Instructions For Use, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Septolet total

Septolete total: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. For violations of liver function
12. 12. Drug interactions
13. 13. Analogs
14. 14. Terms and conditions of storage
15. 15. Terms of dispensing from pharmacies
16. 16. Reviews
17. 17. Price in pharmacies

Latin name: Septolete total

ATX code: R02A

Active ingredient: benzydamine + cetylpyridinium chloride (benzydamine + cetylpyridinium chloride)

Manufacturer: Krka (Slovenia)

Description and photo update: 2018-09-07

Prices in pharmacies: from 198 rubles.

Buy

Septolete total is a combined preparation with anti-inflammatory and antiseptic action.

Release form and composition

• dosed spray for topical application: clear, colorless to yellowish solution [30 ml (250 doses) in polyethylene bottles equipped with a dosing device (pump), 1 bottle in a cardboard box];
• lozenge tablets: round, with beveled edges and a rough surface, blue; possible slight roughness of the edges, uneven coloring, the presence of white bloom and air bubbles in the caramel mass (8 pcs. in blisters, in a cardboard box 1, 2, 3 or 4 blisters).

Composition of 1 spray dose:

• active ingredients: benzydamine hydrochloride - 0.15 mg, cetylpyridinium chloride monohydrate - 0.526 mg, which is equivalent to 0.5 mg of cetylpyridinium chloride;
• auxiliary components: macrogol glyceryl hydroxystearate, sodium saccharinate, glycerol, purified water, ethanol, peppermint leaf oil.

Composition of 1 tablet:

• active ingredients: benzydamine hydrochloride - 3 mg, cetylpyridinium chloride monohydrate - 1.05 mg, which is equivalent to 1 mg of cetylpyridinium chloride;
• auxiliary components: levomenthol, isomalt (type M) (E 953), sucralose (E 955), citric acid (E 330), eucalyptus leaf oil, brilliant blue dye.

Pharmacological properties

Pharmacodynamics

The action of Septolet total is due to the properties of its active substances:

• benzydamine - a non-steroidal anti-inflammatory drug (NSAID) with a local anesthetic effect;
• cetylpyridinium chloride is an antiseptic from the group of quaternary ammonium compounds with antimicrobial, antifungal and disinfectant effects.

Pharmacokinetics

Of the two active substances of Septolet total, only benzydamine is absorbed through the mucous membranes of the oral cavity and pharynx, therefore, at the systemic level, they do not enter into pharmacokinetic interaction with each other.

The absorption of benzydamine through the mucous membranes was confirmed by the presence of the substance in the blood serum. However, its amount is not enough to provide a systemic effect.

When using benzydamine in the form of tablets dispersed in the oral cavity, the absorption of the drug is slightly higher than when it is used in the form of a spray.

The indicators of the volume of distribution, total clearance and half-life for both dosage forms of Septolet total are similar.

The drug is excreted mainly by the kidneys, mainly in the form of inactive metabolites.

Indications for use

According to the instructions, Septolet total is used for the symptomatic treatment of pain in inflammatory diseases of the oral cavity and pharynx of various etiologies.

Contraindications

• children under 18 years old - for a spray, up to 12 years old - for tablets;
• hypersensitivity to any component of the drug.

Septolet total should be used with caution during pregnancy and breastfeeding, with liver diseases, alcoholism, brain diseases, traumatic brain injury, bronchial asthma (including a history), hypersensitivity to acetylsalicylic acid or other NSAIDs.

Instructions for use of Septolete total: method and dosage

Topical spray

Adults are prescribed 1 dose * up to 5 times a day at intervals of at least 2 hours. Duration of treatment is 4 days.

* 1 dose = 2 clicks on the spray head. When pressed once, 0.1 ml of solution is released, which contains 0.15 mg benzydamine and 0.5 mg cetylpyridinium chloride.

To achieve the best effect, it is not recommended to use the drug before brushing your teeth and immediately after it.

If within 4 days the condition does not improve or new symptoms appear, you should consult a doctor.

Before the first use of the spray, it is necessary to calibrate it: press the spray head several times until a uniform cloud of the drug is obtained. If Septolet total has not been applied for more than 7 days, spray the spray into the air once before use.

Rules for using the drug:

1. Remove the protective cap.
2. Open your mouth wide, direct the applicator tube into the oral cavity, hold your breath and press the spray head 2 times.
3. Close the bottle with a protective cap.

Lozenges

Septolete total tablets should be kept in the mouth until they are completely dissolved.

Adults and children from 12 years of age are prescribed 3-4 tablets per day at intervals of 3-6 hours.

The duration of treatment is no more than 7 days.

To achieve the best effect, it is not recommended to use the drug before brushing your teeth and immediately after it.

Side effects

• from the respiratory system: rarely (from> 1/10000 to <1/1000) - bronchospasm;
• from the gastrointestinal tract: very rarely (<1/10000) - burning sensation in the cavity, irritation of the oral mucosa;
• on the part of the nervous system: the frequency is unknown (on the basis of available data, it is not possible to estimate the frequency of side effects) - numbness of the oral mucosa;
• from the skin and subcutaneous tissues: rarely - photosensitization, urticaria; frequency unknown - itching, angioedema;
• from the immune system: rarely - hypersensitivity reactions; frequency unknown - anaphylactic reactions.

Overdose

Symptoms of a benzydamine overdose: chills, increased sweating, vomiting, ataxia, agitation, convulsions.

In case of taking a significant dose of cetylpyridinium chloride inside, nausea, vomiting, cyanosis, arterial hypotension, edema, depression of the central nervous system, asphyxia, followed by paralysis of the respiratory muscles, coma are possible. The lethal dose for humans is approximately 1000–3000 mg.

There is no specific antidote for the drug. Treatment of acute intoxication is symptomatic.

special instructions

Patients with ulcerative lesions of the mucous membrane of the oropharynx, if symptoms persist for more than 3 days, should consult a doctor.

The drug should not be used simultaneously with anionic compounds. Since they are found in toothpastes, it is not recommended to take Septolet total before and after brushing your teeth.

Spray Septolete total in a small amount contains 96% ethanol: in 1 dose - 26.760 mg. Avoid contact of the drug with the mucous membrane of the eyes. Do not inhale.

Milk can reduce the antimicrobial effect of cetylpyridinium chloride, so it is recommended to refrain from drinking it during treatment.

In the event of hypersensitivity reactions, you should immediately cancel Septolet total and consult a doctor to prescribe appropriate therapy.

Influence on the ability to drive vehicles and complex mechanisms

Septolet total does not negatively affect the patient's cognitive and psychomotor functions.

Application during pregnancy and lactation

During pregnancy and breastfeeding, Septolete Total can be used as prescribed by a doctor, who will assess the ratio of the expected benefits and the degree of potential risks.

Pediatric use

Spray Septolete Total is contraindicated in children and adolescents under the age of 18. In tablets, the drug is not prescribed for children under 12 years of age.

For violations of liver function

Septolet total should be used with caution in liver diseases.

Drug interactions

The drug interactions of Septolet total have not been studied.

It is not recommended to take other drugs from the antiseptic group during treatment.

Analogs

There is no information on analogues of Septolet total.

Terms and conditions of storage

Store in its original packaging out of the reach of children, at temperatures up to 25 ° C.

Shelf life is 2 years.

The spray after the first opening of the bottle can be used for no more than 6 months.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Septolet total

Reviews of the Total Septolet are contradictory. There are positive statements confirming the anti-inflammatory and analgesic efficacy of the drug for sore throat. There are also negative reviews, in which patients indicate the lack of effect after using the drug and / or the development of side effects.

Those patients whom Septolet Total helped, its disadvantages include a relatively high price, the lack of a dosage form for children under 12 years old, the presence of dye in the tablets.

Price for Septolet total in pharmacies

Approximate price for Septolet total:

• spray in a bottle of 30 ml - 260–426 rubles,
• lozenges, 16 pcs. in the package - 218-390 rubles.

Septolete total: prices in online pharmacies

Drug name Price Pharmacy

Septolete total 3 mg + 1 mg lozenges 16 pcs. 198 RUB Buy

Septolete total 3 mg + 1 mg elderberry-lemon lozenges 16 pcs. 215 RUB Buy

Septolete total 0.15 mg + 0.5 mg / dose spray for topical application, dosed 30 ml 1 pc. 219 r Buy

Septolete Total tablets for rassas. 3mg + 1mg 16 pcs. 227 r Buy

Septolete total 3 mg + 1 mg honey-lemon resorption tablets 16 pcs. 230 RUB Buy

Septolete Total tablets for rassas. lemon and honey 3mg + 1mg 16 pcs. 234 r Buy

Septolete Total spray for local approx. 0.15mg + 0.5mg 30ml 282 r Buy

Septolete Total tablets for rassas. lemon and elderberry 3mg + 1mg 16 pcs. RUB 300 Buy

See all offers from pharmacies

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!