Sebidin - Instructions For Use, Price, Reviews, Analogs Of Tablets

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Sebidin - Instructions For Use, Price, Reviews, Analogs Of Tablets
Sebidin - Instructions For Use, Price, Reviews, Analogs Of Tablets

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Video: Sebidin - Instructions For Use, Price, Reviews, Analogs Of Tablets
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Sebidine

Sebidin: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. In case of impaired renal function
  12. 12. Drug interactions
  13. 13. Analogs
  14. 14. Terms and conditions of storage
  15. 15. Terms of dispensing from pharmacies
  16. 16. Reviews
  17. 17. Price in pharmacies

Latin name: Sebidin

ATX code: A01AB03

Active ingredient: chlorhexidine (chlorhexidine) + ascorbic acid (ascorbic acid)

Producer: GlaxoSmithKline Pharmaceuticals (Poland)

Description and photo updated: 2019-27-08

Prices in pharmacies: from 156 rubles.

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Lozenges Sebidin
Lozenges Sebidin

Sebidin is a local combined preparation with bactericidal, antiseptic, antibacterial action, used for symptomatic therapy of diseases of the pharyngeal mucosa of infectious and inflammatory genesis.

Release form and composition

Dosage form of release of Sebidin - tablets for resorption: pink-orange, have the form of a flat disc with beveled edges (20 pcs. In blisters, in a cardboard box 1 package and instructions for use of Sebidin).

Active ingredients in 1 tablet:

  • chlorhexidine dihydrochloride - 5 mg;
  • ascorbic acid - 50 mg.

Auxiliary components: sucrose - 546.8 mg, magnesium stearate - 7 mg, methylcellulose - 70 mg, talc - 21 mg, yellow quinoline dye (E104) - 0.15 mg, crimson dye (Ponso 4R) - 0.05 mg, fruit essence (contains a solvent that evaporates during the production process, the amount of the component cannot be calculated).

Pharmacological properties

Pharmacodynamics

Chlorhexidine

The antibacterial effect of chlorhexidine is based on its non-specific binding to phospholipids of bacterial cell membranes. Inside bacterial cell membranes, the substance inhibits the activity of dehydrogenase and ATPase (adenosine triphosphatase), which leads to a violation of the membrane permeability for potassium ions, amino acids and nucleotides.

Chlorhexidine has a bactericidal and bacteriostatic effect, especially on Candida albicans and gram-positive bacteria, and exhibits less activity against gram-negative bacteria.

High sensitivity to the action of chlorhexidine is observed in Moraxella catarrhalis, Selenomonas, Streptococcus anginosus, Streptococcus pyogenes, Haemophilus influenzae and Staphylococcus aureus, Streptococcus mutans, Escherichia coli, Streptococcus salivarius bacteria and Cand. Pseudomonas, Streptococcus sanguis, Proteus, Veillonella species, Klebsiella show less sensitivity.

The severity of the antibacterial action is determined by the concentration. The bacteriostatic effect of chlorhexidine is observed at low concentrations (less than 20 mg / l), bactericidal - at higher concentrations.

Vitamin C

Vitamin C (ascorbic acid) is an essential cofactor of many metabolic reactions, an important antioxidant in the aquatic environment of the human body. The substance maintains the redox balance in the body, promotes the elimination of free radicals.

The main effects of ascorbic acid:

  • takes part in the synthesis of carnitine, steroid hormones and bile acids, prevents the reactions of peroxidation with singlet oxygen and free radicals;
  • required for the formation of collagen and other connective tissue proteins, ensures bone regeneration and integrity and promotes healing of burns and wounds;
  • takes part in intracellular reactions associated with the conversion of folic acid to folic acid, the transformation of aromatic amino acids (tyrosine, phenylalanine) involved in the exchange of adrenaline;
  • helps to remove free radicals that are formed as a result of neutralization of peroxide anions produced by macrophages and activation of neutrophils;
  • participates in reducing the concentration of unbound iron, increasing its use for the synthesis of hemoglobin and utilization.

Pharmacokinetics

Chlorhexidine

The substance is practically not absorbed from the surface of the mucous membrane and skin. When the Sebidin tablet is absorbed, chlorhexidine is slowly released into the saliva. As a result, it binds to the surface of the mucous membrane of the oral cavity and tongue, which is provided by the positive charge of its particles. After that, it is slowly released into saliva again, showing its antibacterial effect.

Chlorhexidine in a small volume can be swallowed with saliva, but the substance is poorly absorbed from the gastrointestinal tract.

It is metabolized in the liver to a minimum, excreted in the intestines with bile.

Typically, approximately 90% of a swallowed dose is excreted in the feces as unchanged substance. Chlorhexidine is detected in body fluids using high performance liquid chromatography with a sensitivity of 1 mg / l.

Vitamin C

It is easily absorbed in the gastrointestinal tract, mainly in the jejunum (absorption of a dose below 200 mg is almost 100%). The maximum serum concentration in the blood is reached in 2–3 hours. Only 25% of the dose taken is in connection with plasma proteins, a significant part is in platelets and leukocytes.

The average equilibrium concentration of the substance is low (about 20 mg / kg), the largest amount is determined in leukocytes, adrenal glands, liver, mucous glands, and brain.

The main metabolites are oxalic acid and L-dehydroascorbic acid with an intermediate form (in the form of L-monodehydroascorbic acid). Only a small amount of ascorbic acid is metabolized to carbon dioxide.

The substance passes into breast milk at a concentration of approximately 1-10 mg%. When excreted with sweat, a high loss of vitamin C is noted; with heavy physical exertion, it can be 2 mg / hour.

Excretion is carried out mainly by the kidneys. Ascorbic acid is excreted either in conjugate form with sulfates, or as metabolites, mainly in the form of oxalic acid.

In the case of a significant excess of the renal excretion threshold (at a plasma concentration of 1.4 mg%), ascorbic acid is excreted as an unchanged substance.

Indications for use

Sebidin is prescribed for the symptomatic treatment of diseases of the pharyngeal mucosa of an infectious and inflammatory etiology.

Contraindications

Absolute:

  • isomaltase / sucrase deficiency, glucose-galactose malabsorption, fructose intolerance;
  • age up to 12 years;
  • hypersensitivity to the components of the drug.

Relative (Sebidin is prescribed with caution in the presence of the following diseases / conditions):

  • deficiency of glucose-6-phosphate dehydrogenase;
  • hemochromatosis;
  • thalassemia;
  • sideroblastic anemia;
  • diabetes mellitus / caries (due to sucrose that is part of Sebidin);
  • kidney stone disease;
  • hyperoxaluria;
  • pregnancy and lactation (the safety profile of the drug for this category of patients has not been studied, taking Sebidin is possible only after assessing the ratio of benefits to risks).

Sebidin, instructions for use: method and dosage

Sebidin tablets are applied topically (kept in the mouth until it is completely absorbed), after brushing your teeth and eating.

Single dose - 1 tablet, frequency of administration - 4 times a day with equal intervals (every 6 hours).

For 2 hours after taking Sebidine, you should not rinse your mouth and drink large quantities of liquid.

The recommended course duration is up to 14 days.

Side effects

  • digestive system: inflammation / irritation of the oral mucosa, nausea, belching, vomiting, soreness of the mucous membranes / tongue, diarrhea, tartar deposits, taste disturbances, irritation of the gastrointestinal mucosa, epigastric pain; during therapy longer than 7 days - short-term staining of acrylic fillings, teeth and tongue;
  • immune system: allergic reactions (in the form of superficial peeling of the oral mucosa, skin rash, in rare cases - swelling of the salivary glands);
  • laboratory parameters: glucosuria, hypokalemia, thrombocytosis, erythropenia, hyperprothrombinemia, neutrophilic leukocytosis;
  • others: inhibition of the function of the insular apparatus of the pancreas (glucosuria, hyperglycemia).

In cases of development of any atypical symptoms, it is necessary to consult a specialist.

Overdose

The likelihood of an overdose of chlorhexidine is small, since it is practically not absorbed from the gastrointestinal tract.

The main symptoms of an overdose (associated mainly with ascorbic acid): hypoglycemia, nausea, diarrhea, flatulence, irritation of the mucous membrane of the gastrointestinal tract, abdominal pain of a spastic nature, nephrolithiasis, frequent urination, irritability, insomnia.

Therapy: symptomatic; forced diuresis, medical supervision is recommended.

special instructions

Reception of Sebidin can distort taste sensations (it is short-term, it is restored after 4 hours).

As a result of long-term therapy, pigmentation of the tongue and teeth develops, it can go away on its own or must be removed by a doctor.

In some cases (in the presence of liver or stomach diseases), the development of gastrointestinal disorders is possible: nausea, vomiting and belching. When these violations appear, Sebidin is canceled.

Ascorbic acid stimulates the synthesis of corticosteroid hormones, in connection with which it is necessary to control blood pressure and adrenal function. With an increased content of iron in the body, ascorbic acid should be used in minimal doses. As a reducing agent, ascorbic acid can distort the results of various laboratory tests (the content of bilirubin, glucose in urine and blood, hepatic transaminase activity).

In the II – III trimesters of pregnancy, the minimum daily requirement for ascorbic acid is about 60 mg. If a woman takes high doses of ascorbic acid during pregnancy, the fetus can adapt to this, which can lead to the development of symptoms of its deficiency in the newborn (baby grief).

When using high doses of ascorbic acid in lactating women, there is theoretically a danger to the child (the daily requirement should not be exceeded).

Influence on the ability to drive vehicles and complex mechanisms

Reception of Sebidin does not affect the mental and physical abilities of a person, and therefore does not interfere with the performance of activities related to the management of vehicles and complex mechanisms.

Application during pregnancy and lactation

Sebidine during pregnancy / lactation is used under medical supervision (provided that the benefits to the mother exceed the potential risk to the fetus / child).

Pediatric use

Patients under 12 years of age are not prescribed Sebidin.

With impaired renal function

With kidney stones, Sebidin is prescribed with caution.

Drug interactions

If necessary, Sebidin can be taken in combination with other topical drugs with antimicrobial action.

The effectiveness of the drug is enhanced by ethanol.

During the period of therapy, it is necessary to take into account the possibility of developing the interaction of the active substances of Sebidin.

Chlorhexidine:

  • pharmaceutical incompatibility: soap, alkalis and other anionic compounds (gum arabic, colloids, carboxymethyl cellulose);
  • pharmaceutical compatibility: preparations containing a cationic group (benzalkonium chloride, cetrimonium bromide).

With the combined use of ascorbic acid with certain drugs / substances, the following effects may develop:

  • heparin and indirect anticoagulants: decrease in their effectiveness;
  • benzylpenicillin, tetracyclines: increasing their concentration in the blood;
  • oral contraceptives, acetylsalicylic acid, alkaline drinks, fresh juices: decreased absorption and assimilation;
  • salicylates, short-acting sulfonamides: the likelihood of developing crystalluria;
  • acetylsalicylic acid: increased urinary excretion and decreased absorption of ascorbic acid, decreased excretion of acetylsalicylic acid;
  • antipsychotic drugs (neuroleptics) - phenothiazine derivatives: reducing the therapeutic effect;
  • acids: slowing down their excretion by the kidneys;
  • oral contraceptives: a decrease in their concentration in the blood;
  • drugs with an alkaline reaction (including alkaloids): an increase in their excretion;
  • ethanol: increasing its total clearance, reducing the concentration of ascorbic acid in the body;
  • primidone, barbiturates: increased excretion of ascorbic acid in the urine;
  • isoprenaline: decrease in chronotropic action;
  • amphetamine, tricyclic antidepressants: decreased tubular reabsorption.

Analogs

Analogues of Sebidin are: Grammidin Neo, Coldakt Lorpils, Strepsils, Ajisept, Astrasept, Gorpils, Lizobakt, Neo-Angin, Septogal and others.

Terms and conditions of storage

Store in a dark, dry place out of reach of children at temperatures up to 25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Sebidin

Most reviews of Sebidin indicate its high effectiveness, affordable cost and good tolerance. Users indicate that the tablets taste good. In some cases, the drug is used as part of a combination therapy.

The price of Sebidin in pharmacies

The approximate price for Sebidin (20 tablets) is 116-130 rubles.

Sebidin: prices in online pharmacies

Drug name

Price

Pharmacy

Sebidin lozenges 20 pcs.

156 r

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Sebidin tablets for rassas. 5mg + 50mg 20 pcs.

192 RUB

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Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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