Gluconorm
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Prices in online pharmacies:
from 70 rubles.
Buy
Gluconorm is a combined oral hypoglycemic drug.
Release form and composition
Dosage form - film-coated tablets: round, convex on both sides, almost white or white; at the break - from white to white-grayish color (10 pcs. in a blister, 4 blisters in a cardboard box; 20 pcs. in a blister, 2 blisters in a cardboard box).
Active ingredients in 1 tablet:
- metformin hydrochloride - 400 mg;
- glibenclamide - 2.5 mg.
Additional components: diethyl phthalate, croscarmellose sodium, glycerol, gelatin, corn starch, cellacephate, purified talc, colloidal silicon dioxide, sodium carboxymethyl starch, microcrystalline cellulose, magnesium stearate.
Indications for use
Gluconorm is used for diabetes mellitus in the following cases:
- ineffectiveness of diet therapy, exercise and previous monotherapy with glibenclamide or metformin;
- conditions in which the level of glucose in the blood is well controlled by the use of two drugs (metformin and glibenclamide) - to replace them.
Contraindications
- hypoglycemia;
- diabetic ketoacidosis, diabetic precoma and coma;
- type 1 diabetes mellitus;
- acute conditions that can lead to changes in kidney function (dehydration, severe infection, shock);
- severe renal dysfunction;
- liver failure;
- acute and chronic diseases accompanied by tissue hypoxia (for example, recent myocardial infarction, respiratory or heart failure, shock);
- extensive burns, trauma, major surgical interventions, infectious diseases and other conditions requiring insulin therapy;
- porphyria;
- lactic acidosis (including history);
- chronic alcoholism or acute alcohol intoxication;
- simultaneous administration of miconazole;
- adherence to a hypocaloric diet (less than 1000 cal / day);
- carrying out a radioisotope or X-ray examination with the introduction of an iodine-containing contrast agent (within 48 hours before and 48 hours after);
- the period of pregnancy and breastfeeding;
- hypersensitivity to any component of the drug or other sulfonylurea derivatives.
Gluconorm is not recommended to be prescribed to patients over 60 years of age who perform heavy physical work.
Caution during treatment is required in the following cases:
- diseases of the thyroid gland, accompanied by a violation of its function;
- hypofunction of the anterior pituitary gland;
- adrenal insufficiency;
- febrile syndrome.
Method of administration and dosage
Gluconorm is indicated for oral administration. The tablets must be taken with meals.
The appropriate dose for each patient is selected individually based on the data on the level of glucose in the blood.
The initial dose is usually 1 tablet once a day. If necessary, the dose is increased every 1–2 weeks until the desired effect is achieved.
In the case of prescribing Gluconorm, instead of a combination of two drugs - metformin and glibenclamide - the dose is determined depending on the previous doses of each of the components, usually 1-2 tablets are prescribed.
The maximum allowable dose is 5 tablets per day.
Side effects
- from the hematopoietic system: rarely - erythrocytopenia, leukopenia, thrombocytopenia; very rarely - hemolytic or megaloblastic anemia, agranulocytosis, pancytopenia;
- from the side of metabolism: lactic acidosis;
- from the gastrointestinal tract and liver: rarely - metallic taste in the mouth, abdominal pain, nausea, loss of appetite, vomiting; in some cases - increased activity of liver enzymes, cholestatic jaundice, hepatitis;
- from the side of carbohydrate metabolism: hypoglycemia is possible;
- from the central nervous system: increased fatigue, dizziness, headache, weakness; rarely - sensitivity disorders, paresis;
- dermatological, allergic and immunopathological reactions: rarely - photosensitization, fever, pruritus, arthralgia, erythema, proteinuria, urticaria;
- others: an acute reaction of alcohol intolerance (disulfiram-like reaction) after taking it, expressed by complications from the circulatory and respiratory organs (sensation of heat in the face and upper body, headache, dizziness, vomiting, tachycardia).
special instructions
During the period of therapy, fasting blood glucose and after meals should be kept under control.
During fasting, in the case of the simultaneous use of non-steroidal anti-inflammatory drugs and ethanol, the risk of hypoglycemia increases.
When changing the diet, physical and emotional stress, correction of the dosage regimen is required.
Reception of Gluconorm must be discontinued 48 hours before surgery or intravenous administration of a radiopaque contrast agent, and can be resumed no earlier than 48 hours after the intervention / study.
During the period of treatment, you should not drink alcohol, it is recommended to be careful when driving and performing potentially hazardous work that requires quick reactions and increased attention.
Drug interactions
Cationic drugs secreted in the tubules (ranitidine, quinidine, procainamide, digoxin, triamterene, morphine, vancomycin, amiloride, quinine), with prolonged use, can increase the maximum concentration of metformin by 60%.
Metformin reduces the half-life and the maximum concentration of furosemide by 42.3 and 31%, respectively.
Nifedipine increases the absorption and slows down the excretion of metformin, furosemide increases its maximum concentration (by 22%).
In the case of alcohol consumption during treatment, the risk of lactic acidosis increases.
Medicines that acidify urine (high doses of ascorbic acid, ammonium chloride and calcium chloride) enhance the effect of glibenclamide.
The hypoglycemic effect of Gluconorm is enhanced by the following drugs: tubular secretion blockers, salicylates, histamine H 2 blockers-receptors (cimetidine), anabolic steroids, monoamine oxidase inhibitors, antifungal agents (miconazole, fluconazole), coumarin anticoagulants, angiotensin converting enzyme inhibitors (captopril, enalapril), long-acting sulfonamides, long-acting drugs (etifibonuberculosis)), beta-blockers, non-steroidal anti-inflammatory drugs (phenylbutazone, azapropazone, oxyphenbutazone), other hypoglycemic drugs (acarbose, biguanides, insulin), as well as theophylline, fenfluramine, pyridoxine, chloramphenicol, disokanefluramidin, pyridoxine, chloramphenicol, disokiramiramidin, tetracycline allopurinol, reserpine, fluoxetine.
The effect of Gluconorm is weakened by the following drugs: thiazide diuretics, iodine-containing thyroid hormones, slow calcium channel blockers, adrenostimulants (epinephrine, clonidine), barbiturates, lithium salts, carbonic anhydrase inhibitors (acetazolamide), antiepileptic drugs, erythrocytosis) danazol, asparaginase, furosemide, glucagon, morphine, triamterene, ritodrin, rifampicin, isoniazid, baclofen, salbutamol, chlorthalidone, terbutaline, chlorpromazine, diazoxide, high doses of nicotinic acid.
Analogs
Glyukonorm analogs are: Glibomet, Bagomet Plus, Glukovans.
Terms and conditions of storage
Store in a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Gluconorm: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Altai herbal tea No. 11 Gluconorm herbal tea 2 g 20 pcs. RUB 70 Buy |
|
Gluconorm Plus 2.5 mg + 500 mg film-coated tablets 30 pcs. RUB 165 Buy |
|
Gluconorm 2.5 mg + 400 mg film-coated tablets 40 pcs. RUB 176 Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
