Hexoral tabs
Hexoral tabs: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Use in the elderly
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Hexoral tabs
ATX code: A01AB12
Active ingredient: Amylmetacresol + Dichlorobenzyl alcohol (Amylmetacresol + Dichlorobenzyl alcohol)
Producer: Catalent Germany Schorndorf, GmbH (Germany)
Description and photo update: 2018-23-10
Prices in pharmacies: from 150 rubles.
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Hexoral tabs is a drug for local use in dentistry and ENT practice, which has antimicrobial and local anesthetic effect.
Release form and composition
Release form Hexoral tabs - lozenges: round, biconvex, with a rough surface, opaque, from white / yellowish white to light gray / yellowish gray; dusting is possible (the appearance of white bloom), slight roughness of the edges, the presence of bubbles and uneven coloring (10 pcs. in blisters, 2 blisters in a cardboard box).
Composition of 1 tablet:
- active substances: chlorhexidine dihydrochloride - 5 mg, benzocaine - 1.5 mg;
- additional components: isomalt - 2243.681 mg, purified water - 45.789 mg, aspartame - 2.29 mg, peppermint oil - 0.9 mg, menthol - 0.645 mg, thymol - 0.045 mg.
Pharmacological properties
Pharmacodynamics
The action of Hexoral tabs is due to the properties of two active substances included in its composition: chlorhexidine - an antibacterial agent, benzocaine - a local anesthetic that reduces pain symptoms.
Chlorhexidine is characterized by a broad antibacterial spectrum of action against gram-positive and gram-negative bacteria. The mechanism of its action is explained by its ability to destroy the cytoplasmic membrane of a bacterial cell. Ineffective for diseases caused by mycobacteria, yeasts, dermatophytes, some species of Proteus and Pseudomonas. Most effective in slightly alkaline and neutral environments. Its activity decreases in an acidic environment, in the presence of purulent secretions and blood. Due to the content of chlorhexidine in Hexoral Tabs resorption tablets, there is a significant reduction in the content of bacteria in saliva. With prolonged use, the effectiveness of the substance decreases due to a decrease in the sensitivity of bacteria.
Benzocaine is a common local anesthetic that quickly and permanently relieves pain in the mouth and throat. The mechanism of its action is due to the ability to penetrate the lipophilic areas of the cell membrane and act on peripheral pain receptors of the mucous membrane and skin. The analgesic effect of the drug occurs 15-30 seconds after administration and gradually decreases as the substance is diluted with saliva (within 5-10 minutes).
Pharmacokinetics
Clinical data on the absorption of chlorhexidine through the oral mucosa are absent. The substance remains in saliva for up to 8 hours.
Benzocaine is characterized by slow absorption, since it is slightly soluble in water. Like other ester derivatives of para-aminobenzoic acid, it is cleaved by esterase in the liver and blood plasma, resulting in the formation of para-aminobenzoic acid and ethyl alcohol. Para-aminobenzoic acid is conjugated with glycine or excreted by the kidneys unchanged. Ethyl alcohol is metabolized to acetyl coenzyme A.
Indications for use
Hexoral tabs is used to treat infectious and inflammatory diseases of the mouth and throat, including stomatitis, pharyngitis, gingivitis, sore throat, etc.
Contraindications
- ulcerative or wound lesions of the mouth / throat;
- phenylketonuria;
- low concentration of cholinesterase in blood plasma;
- children under 4 years of age;
- hypersensitivity to any component of the drug.
Hexoral tabs should be used with caution and only under the supervision of a physician in case of erosive and desquamative changes in the oral mucosa, as well as in childhood, in patients with swallowing or aspiration disorders.
Instructions for the use of Hexoral tabs: method and dosage
Hexoral tabs is used topically, dissolving the tablets in the oral cavity until they are completely dissolved.
Unless otherwise prescribed, adults and adolescents over 12 years of age should take 1 tablet as needed, at intervals of at least 1-2 hours, but no more than 8 times a day.
Children 4-12 years old are allowed to take no more than 4 tablets per day.
It is recommended to start treatment as early as possible after the first signs of the disease appear and continue for several days after the unpleasant symptoms disappear.
Side effects
Hexoral tabs is generally well tolerated. The following are side effects, the frequency of which is not possible to estimate, as they are described in spontaneous reports of adverse reactions:
- from the gastrointestinal tract: reversible discoloration of the tongue, the formation of dental plaque (tartar), discoloration of teeth or silicate and composite materials of dental restoration, temporary numbness of the tongue, decreased sensitivity and detachment of the oral mucosa, stomatitis, taste disturbance (dysgeusia), an increase in the parotid salivary glands, glossodynia;
- from the immune system: hypersensitivity reactions, including anaphylactic reactions, angioedema, urticaria, anaphylactic shock;
- on the part of the blood and lymphatic system: methemoglobinemia.
Overdose
If the dosage regimen of Hexoral tabs is observed, an overdose is impossible, since chlorhexidine is practically not absorbed into the bloodstream, and the amount of benzocaine that has entered the blood is extremely low.
In addition, chlorhexidine hydrochloride is poorly soluble in water, and known cases of overdose have occurred when taking chlorhexidine gluconate, which is highly soluble in water. In such patients, damage to the mucous membrane (in the case of direct contact with the substance) and a systematic reversible increase in the concentration of liver enzymes occurred. No specific treatment methods have been developed.
An overdose of benzocaine is possible if it is misused. Signs of intoxication: vomiting, tremors, convulsions, depression of the central nervous system and respiration, coma. In high toxic concentrations, benzocaine can cause blockade of atrioventricular conduction, bradycardia, and cardiac arrest. There is also a risk (especially in children) of developing methemoglobinemia, accompanied by cyanosis and suffocation.
In case of an overdose of benzocaine, it is necessary to artificially induce vomiting, rinse the stomach and take activated charcoal. In the case of anoxia and hypoxia, artificial respiration with oxygen support is indicated; in case of cardiac arrest, massage is performed; for convulsions (with the exception of anoxic), fast-acting barbiturates or diazepam are prescribed. In especially severe cases, after intubation and artificial respiration, suxamethonium chloride is used. The introduction of solutions of electrolytes or blood plasma supports blood circulation. With methemoglobinemia, intravenous administration of 1% methylene blue solution (up to 50 ml) is possible.
special instructions
Information for diabetics: each tablet contains carbohydrates, the amount of which corresponds to 0.1 bread unit.
In connection with the risk of developing methemoglobinemia during treatment, special attention should be paid to the possible appearance of symptoms such as fatigue, shortness of breath, headache, paleness or discoloration of the lips, nail beds and skin to a gray or blue color, tachycardia, and light-headedness. When they appear, taking the drug should be stopped immediately and consult a doctor, since these signs indicate the presence of a moderate or high amount of methemoglobin and a significant decrease in the oxygen transport function of the blood. Children and elderly patients are in a special risk group.
Hexoral tabs is contraindicated in phenylketonuria, because it contains aspartame.
Influence on the ability to drive vehicles and complex mechanisms
The drug does not have the ability to negatively affect the speed of reactions and the ability to concentrate.
Application during pregnancy and lactation
Due to the lack of sufficient clinical experience with the use of the drug during pregnancy and lactation, Hexoral tabs during these periods can be used for treatment only if the expected benefit outweighs the potential risks to the fetus / child.
Pediatric use
According to the instructions, Hexoral tabs is strictly contraindicated in children under 4 years of age, at an older age, taking the drug is possible only as directed by a doctor, under the close supervision of adults.
Use in the elderly
It should be borne in mind that elderly patients have a higher risk of developing methemoglobinemia while taking the drug.
Drug interactions
Benzocaine reduces the antibacterial effect of aminosalicylates and sulfonamides.
The effect of chlorhexidine with simultaneous use is reduced by polysorbate 80, sucrose, insoluble salts of zinc, calcium and magnesium.
Analogs
According to the mechanism of action, the analogs of Hexoral tabs are: Stopangin, Maxisprey, Maxicold Lor, Stomatidin, Hexetidine, etc.
Terms and conditions of storage
Store for no more than 3 years out of the reach of children at temperatures up to 25 ° C.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Hexoral tabs
Patients who have taken the drug leave mostly positive reviews about Hexoral tabs. In their experience, the drug quickly and effectively eliminates pain in the mouth and throat, the main condition is to start taking it when the first symptoms of the disease appear.
Additional benefits include the pleasant taste of the tablets and the almost complete absence of side effects, provided that the recommended dosage regimen is observed.
Price for Hexoral tabs in pharmacies
The price of Geksoral tabs is 135-235 rubles for a pack of 20 tablets.
Hexoral tabs: prices in online pharmacies
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Drug name Price Pharmacy |
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Hexoral tabs classic honey-lemon resorption tablets 16 pcs. RUB 150 Buy |
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Geksoral tabs classic blackcurrant lozenges 16 pcs. 154 RUB Buy |
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Hexoral Tabs Classic tablets for rassas. honey-lemon 16 pcs. 155 RUB Buy |
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Hexoral tabs classic orange flavored lozenges 16 pcs. 155 RUB Buy |
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Hexoral Tabs Classic tablets for rassas. orange 16 pcs. 159 r Buy |
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Geksoral tabs lozenges 20 pcs. 167 r Buy |
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Hexoral tabs classic lozenges lemon 16 pcs. 167 r Buy |
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Hexoral tabs lozenges 20pcs 168 RUB Buy |
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Hexoral Tabs Classic tablets for rassas. black currant 16 pcs. 177 r Buy |
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Hexoral Tabs Classic tablets for rassas. lemon 16 pcs. RUB 180 Buy |
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Geksoral tabs extra sucking tablets lemon 16 pcs. 191 r Buy |
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Hexoral Tabs Extra tablets for rassas. lemon 16 pcs. 196 r Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
