Biltricide
Instructions for use:
- 1. Composition and form of release
- 2. Pharmacological action
- 3. Indications for use
- 4. Contraindications
- 5. Method of administration and dosage regimen
- 6. Application during pregnancy and breastfeeding
- 7. Side effects
- 8. Drug interactions
- 9. Storage conditions
Biltricide is an anthelmintic drug.
Composition and form of release
Biltricid is produced in the form of film-coated tablets. The main active ingredient in each tablet is 600 mg of praziquantel. Auxiliary components of the preparation: microcrystalline cellulose, corn starch, sodium lauryl sulfate, titanium dioxide, macrogol 4000, magnesium stearate, hypromellose, povidone.
In dark glass vials, 6 pcs.
Pharmacological action of Biltricid
According to the instructions, biltricide is an anthelmintic drug that increases the permeability of helminth cell membranes for calcium ions. This, in turn, stimulates the generalized contraction of the muscles of the parasites and stops the uptake of glucose by helminth cells. At the same time, the use of Biltricide reduces the level of glycogen and stimulates the release of lactic acid compounds, which leads to the death of parasites. Praziquantel is specifically active against cestodes and trematodes.
Indications for the use of Biltricid
According to the instructions, Biltricide is prescribed for the treatment of infections caused by all kinds of schistosomes (Schistosoma mekongi, Schistosoma intercalatum, Schistosoma haematobium, Schistosoma japonicum, Schistosoma mansoni), as well as those caused by hepatic flukes (Opistorchis viverrini, Clonorchis sinus) fluke
Contraindications
The use of Biltricid is contraindicated in the following cases:
- Hypersensitivity to the main or auxiliary components of the drug;
- Children up to age four;
- In combination with rifampicin;
- Cysticercosis of the eyes.
According to reviews, Biltricid should be prescribed with caution in cardiac arrhythmias, hepatolienal schistosomiasis, decompensated liver failure.
Method of application of Biltricid and dosage regimen
According to the instructions, Biltricid is intended for oral administration. The tablet is taken whole, without chewing, with a little water. Reception should be carried out shortly before or immediately during a meal. If the recommended dosage of Biltricid is 1 tablet per day, then it is better to take it in the evening. If the use of Biltricid is repeated throughout the day, then an interval of 4-6 hours must be observed between taking the tablets.
Dosages of Biltricide are set individually, depending on the type of pathogen.
According to the instructions, Biltricid is prescribed for children over four years of age and for adults in the following dosages:
- Single dose of 40 mg / kg body weight for infections caused by Schistosoma haematobium;
- 20 mg / kg twice a day or 40 mg / kg body weight once for infections caused by Schistosoma intercalatum and Schistosoma mansoni;
- 30 mg / kg body weight twice a day or 60 mg / kg once for infections caused by Schistosoma japonicum, Schistosoma mekongi;
- At 25 mg / kg body weight three times a day for 1-3 days for infections caused by Clonorchis sinensis, Opisthorchis viverrini, Paragonimus westermani.
The use of Biltricid during pregnancy and breastfeeding
According to reviews, Biltricide is not recommended to be prescribed in the first trimester of pregnancy. Since praziquantel passes into breast milk, it is recommended to suspend breastfeeding for the period of taking Biltricide, and also on the next day after the end of taking the drug.
Side effects
According to reviews, Biltricide can cause the following side effects:
- Cardiovascular system: arrhythmia.
- Digestive system: vomiting, nausea, abdominal pain, bloody diarrhea, loss of appetite.
- Musculoskeletal system: myalgia.
- Central nervous system: dizziness, headache, convulsions, drowsiness.
- Allergic reactions: urticaria, generalized allergic reactions, including polyserositis.
- Other side effects: fever, asthenia.
Biltricide drug interactions
When Biltricide is combined with anticonvulsants, drugs that induce liver enzymes of the cytochrome P450 system, dexamethasone, a decrease in the concentration of the main component of Biltricide in the blood plasma may occur. When Biltricide is combined with drugs that inhibit liver enzymes of the cytochrome P450 system, the concentration of praziquantel may, on the contrary, increase in blood plasma.
The simultaneous use of biltricide and chloroquine leads to a decrease in the level of praziquntel in the blood plasma.
Storage conditions
According to the instructions, Biltricid belongs to List B drugs with a recommended shelf life of 5 years.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
