Pancreatin - Instructions, Application, Indications

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Pancreatin

Instructions for use:

1. 1. Composition and form of release
2. 2. Pharmacological action
3. 3. Indications for use
4. 4. Method of application and dosage regimen
5. 5. Contraindications to use
6. 6. Side effects
7. 7. Overdose
8. 8. Application during pregnancy and lactation
9. 9. Drug interactions
10. 10. Terms and conditions of storage

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from 15 rubles.

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Pancreatin is a drug that improves digestion.

Composition and form of release

Pancreatin is produced in the form of biconvex tablets, coated with a light pink color. The composition of 1 tablet contains 192 mg pancreatin powder. Auxiliary components: sodium chloride, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, talc, titanium dioxide, oydragit L 30 D-55 or oydragit L-100, acid red 2 C, croscarmellose sodium.

pharmachologic effect

The use of Pancreatin aids in digestion. Replenishes the lack of pancreatic enzymes, has a proteolytic, amylolytic and lipolytic effect, enhances the breakdown of carbohydrates, proteins and fats in the duodenum, due to which their more complete and rapid absorption occurs. Normalizes digestion processes and improves the functioning of the gastrointestinal tract.

The following enzymes are part of Pancreatin: alpha-amylase, proteases (chymotrypsin and trypsin), lipase.

Under normal intestinal microflora, amylase breaks down starch first to dextrins and then to maltose.

Thanks to lipase, neutral fat is broken down to fatty acids and monoglycerides, which, due to interaction with bile acids, are quickly absorbed in the upper part of the small intestine.

Proteases help proteins break down into free amino acids and polypeptides.

The shell of the tablets does not dissolve in the acidic environment of the stomach and does not allow pancreatic enzymes to break down under the influence of gastric juice.

Indications for use

The indication for Pancreatin is replacement therapy for exocrine pancreatic insufficiency:

• pancreatectomy;
• dyspepsia;
• chronic pancreatitis;
• cystic fibrosis (cystic fibrosis);
• condition after irradiation.

Also, according to the instructions, Pancreatin is prescribed for:

• diarrhea of non-infectious genesis, flatulence;
• chronic diseases of the biliary tract, obstruction of the biliary tract or pancreatic ducts;
• impaired assimilation of food, including after resection of the small intestine or stomach;
• preparation for ultrasound and X-ray of the abdominal organs with the aim of degassing the intestines.

The indication for Pancreatin is a violation of chewing function, as well as excessive food intake or the use of indigestible plant foods by persons with normal gastrointestinal tract function.

Method of administration and dosage regimen

According to the instructions, Pancreatin is intended for oral administration. The tablets are drunk with or immediately after a meal with plenty of liquid. The dosage depends on the age of the patient and the indication for Pancreatin.

As a rule, according to the instructions, Pancreatin is prescribed in a dosage of 1-4 tablets with each meal. If necessary, the dose can be increased by 1.5-2 times. The maximum daily dosage for adults is 21 tablets. In case of complete insufficiency of the exocrine function of the pancreas, the dosage can be increased to 57 tablets per day, which is the daily requirement of a person for lipase.

The maximum daily requirement for lipase in an adult is 15-20 thousand Ph. Eur. U. (ME) lipase / kg body weight, which corresponds to 2-3 tablets / kg body weight.

With cystic fibrosis, children under four years of age are prescribed Pancreatin according to the instructions at a dosage of 1 tablet / 7 kg of body weight. For children over four years of age, the dosage is 1 tablet / 14 kg of body weight.

The duration of therapy is from several days to several months, depending on the indications for Pancreatin. If permanent substitution therapy is required, the duration of treatment can be several years.

Contraindications to the use of Pancreatin

According to the instructions, Pancreatin is contraindicated in such cases:

• children's age up to two years;
• acute pancreatitis;
• intestinal obstruction;
• exacerbation of chronic pancreatitis;
• hypersensitivity to the components of the drug.

Side effect

According to reviews, Pancreatin is well tolerated by patients. Sometimes the following side effects may occur:

• Digestive system: constipation or diarrhea, nausea, discomfort in the epigastric region. With cystic fibrosis, Pancreatin, according to reviews, can cause small bowel obstruction, stricture in the ileocecal and ascending colon.
• Other side effects: perianal irritation, impaired absorption of folic acid, allergic reactions (with lactose intolerance and hypersensitivity to drug components).

According to reviews, Pancreatin with prolonged use can cause hyperrucosuria, and with excessive doses, hyperuricemia.

Overdose

An overdose of Pancreatin according to reviews causes the following symptoms: hyperuricemia, hyperuricosuria. An overdose of the drug in children can cause constipation. In these cases, the use of Pancreatin should be canceled and symptomatic therapy should be carried out.

Application during pregnancy and lactation

The safety of the drug during pregnancy has not been fully studied, therefore, during this period, Pancreatin is prescribed according to the instructions only when the ratio of the risk of the mother and the fetus is.

According to reviews, Pancreatin can be used during lactation.

Drug interactions

The appointment of Pancreatin according to the instructions in combination with iron preparations and folates reduces their absorption. The simultaneous use of Pancreatin with antacids, alcohol-containing agents, tannin reduces the effect of the drug.

Storage term and conditions

Store in a cool dry place at a temperature not exceeding 15 degrees. The shelf life is 24 months.

Pancreatin: prices in online pharmacies

Drug name Price Pharmacy

Pancreatin 25 IU enteric-coated tablets 20 pcs. RUB 15 Buy

Pancreatin 25 IU tablets p.o. enteric solution. 20 pcs. RUB 21 Buy

Pancreatin 30 IU enteric-coated tablets 60 pcs. RUB 33 Buy

Pancreatin 25 IU enteric-coated tablets 60 pcs. 34 rbl. Buy

Pancreatin 25 IU enteric-coated tablets 60 pcs. 34 rbl. Buy

Pancreatin enteric-coated tablets 20 pcs. 35 RUB Buy

Pancreatin 30 IU enteric-coated tablets 60 pcs. RUB 39 Buy

Pancreatin 2.8 + 3 + 0.18 thous. Unit Ef. F. enteric-coated tablets 50 pcs. 43 rbl. Buy

Pancreatin 25 IU enteric-coated tablets 60 pcs. 43 rbl. Buy

Pancreatin 25 IU enteric-coated tablets 60 pcs. RUB 51 Buy

Pancreatin forte enteric-coated tablets 20 pcs. RUB 51 Buy

Pancreatin 30 IU tablets p.o. enteric solution. 30ED 60 pcs. 52 RUB Buy

Pancreatin forte tab. p / o intestinal. No. 20 RUB 58 Buy

Pancreatin tablets c.p. 125 mg 50 pcs. RUB 67 Buy

Pancreatin 25 IU tablets p.o. enteric solution. 60 pcs. Avexima Siberia RUB 67 Buy

Pancreatin 25 IU tablets p.o. enteric solution. 60 pcs. Irbitsky KhFZ 77 RUB Buy

Pancreatin forte enteric-coated tablets 60 pcs. RUB 98 Buy

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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!