Albumen
Albumin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Use in the elderly
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Albumin
ATX code: B05AA01
Active ingredient: albumin (albumin)
Manufacturer: Sverdlovsk Regional Blood Transfusion Station GUZ (Russia), Microgen NPO FSUE (Russia), Sangvis SPK No. 2 SO GUZ (Russia)
Description and photo update: 2019-16-09
Prices in pharmacies: from 1596 rubles.
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Albumin is a plasma-substituting agent.
Release form and composition
The drug is produced in the form of a solution for infusion: a clear yellow liquid with a possible green tint (20% solution of 50 or 100 ml, 5% and 10% solutions of 50, 100, 200 or 400 ml in a glass bottle of 50, 100, 250 or 500 ml, respectively, the bottle is hermetically sealed with a rubber stopper and crimped with an aluminum cap, 5%, 10% and 20% solutions of 10 or 20 ml in a glass ampoule, in a cardboard box 1 bottle or 10 ampoules complete with an ampoule knife and instructions for use Albumin; if the ampoules have a fracture, a notch or an identification colored dot on the ampoule clamp, the ampoule knife is absent in the pack).
1 ml of the preparation contains:
- active substance: albumin - 50, 100 or 200 mg;
- additional components: sodium chloride, sodium caprylate, water for injection.
Pharmacological properties
Albumin is a natural protein that is part of the protein fraction of human blood plasma. The molecular weight of albumin is 69,000 daltons. Solutions of the drug 5%, 10% and 20% are used to correct hypoalbuminemia of various nature, restore and maintain colloidal-osmotic (oncotic) pressure and water-electrolyte balance, eliminate violations of central and peripheral hemodynamics. The product also demonstrates detoxification properties.
In the body, albumin provides the binding and transport of fatty acids, pigments (including bilirubin), ions of certain metals and medicinal substances. The drug is characterized by a high binding capacity in relation to toxins and further inactivates the latter.
Indications for use
- a decrease in the level of total protein content below 50 g / l, a decrease in the concentration of albumin in plasma below 30 g / l or the level of colloid osmotic pressure below 15 mm Hg. Art.;
- hypoalbuminemia of various etiologies: acute blood loss [decrease in circulating blood volume (BCC) by more than 25-30%], shock (traumatic, hemorrhagic, thermal), purulent-septic conditions, burn disease, kidney disease (including nephritis and nephrotic syndrome), liver diseases occurring with a violation of its albumin-producing function;
- hemolytic disease of newborns during exchange (exchange) blood transfusion;
- operations performed using artificial blood circulation;
- preoperative hemodilution and preparation of autologous blood components;
- swelling of the brain;
- therapeutic plasmapheresis.
Contraindications
Absolute:
- severe heart failure (stage IIB – III);
- uncontrolled arterial hypertension;
- cerebral hemorrhage;
- thrombosis;
- internal bleeding;
- pulmonary edema;
- hypervolemia;
- hypersensitivity to any of the components of the product.
Relative (the drug must be used with extreme caution):
- arterial hypertension;
- stage I heart failure;
- renal failure.
Albumin, instructions for use: method and dosage
Albumin solution is administered intravenously, drip or stream.
A single dose of the drug is set individually, taking into account the severity of the lesion, the condition and age of the patient, as well as the concentration of the solution. The average single dose of 5%, 10% and 20% Albumin is 200-300 ml. If necessary, it is possible to increase the dose of 5% solution to 500–800 ml at an infusion rate of no more than 50–60 drops per minute. A single dose of 20% Albumin should not be higher than 100 ml.
It is recommended to infuse 10% and 20% albumin solution at a rate not exceeding 40 drops per minute. For the treatment of cerebral edema, hyperoncotic 10%, 20% solutions of the drug are prescribed.
If a rapid increase in blood pressure (blood pressure) is necessary against the background of shock of various origins (hemorrhagic, traumatic, thermal), jet injection of the drug is allowed.
Before carrying out a drug transfusion, the attending physician must conduct a thorough visual examination of the solution and the container in which it is contained. In the absence of transparency of the solution or detection of suspension and sediment in it, it is prohibited to inject the drug. Plasma-substituting agent can be used for infusion only if the tightness of the closure is preserved, the label is intact and the bottle is not cracked. The medical history must record the results of the examination of the drug and the data indicated on the label (including the name of the drug, batch number, manufacturer).
Side effects
Against the background of drug therapy, in rare cases, the appearance of such undesirable effects as an increase in body temperature, urticaria, chills, shortness of breath, tachycardia, a decrease in blood pressure, pain in the lumbar region can be observed.
If the development of undesirable phenomena or complications is noted, it is necessary to immediately stop the administration of the drug and, without removing the needle from the vein, inject glucocorticoids, cardiotonic, antihistamines, vasopressor drugs (with the appropriate indications).
Overdose
There is no data.
special instructions
With dehydration of the body, the use of the drug is possible only after preliminary implementation of oral and parenteral rehydration (fluid replacement).
If the solution was frozen during transportation, it can be injected in the case when it has not changed its appearance after thawing.
When using the product, there is a risk of infection with blood-borne infections.
Application during pregnancy and lactation
The use of a plasma-substituting agent during pregnancy / lactation is allowed only when the expected benefit of therapy for the mother outweighs the possible threat to the health of the fetus / child.
Pediatric use
For children, the dosage of Albumin solutions, taking into account their concentration, must be calculated in ml / kg of body weight, the maximum dose should not exceed 3 ml / kg.
With impaired renal function
In the presence of renal failure, the drug should be used with caution.
Use in the elderly
Elderly patients are not recommended to use concentrated (20%) solutions of the drug, and patients of this age category should beware of the rapid administration of Albumin 10% and 5%, as this can overload the cardiovascular system.
Drug interactions
- phenylbutazone, penicillins, barbiturates, sulfonamides, salicylates: there is a weakening of the therapeutic effect of albumin;
- amino acid solutions, protein hydrolysates, alcohol-containing preparations: it is recommended to avoid the simultaneous use of these funds with the preparation.
Analogs
Analogs of Albumin are: Human serum albumin, Uman albumin, Alburex, Plasbumin-20, Human albumin Biotest, Zenalb-20, Albiomin 20%, Zenalb-4.5.
Terms and conditions of storage
Store out of the reach of children at a temperature of 2-10 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Albumin
On medical forums, there are very few reviews about Albumin, since this plasma-substituting agent is used in a hospital setting and is most often prescribed in critical cases. Experts say that the use of the drug in the treatment of many lesions of internal organs, leading to a decrease in the level of total protein and in particular albumin, significantly improves the prognosis for patients. Currently, due to the high cost of the drug, it is often replaced (except for the correction of severe hypoalbuminemia) with alternative means - modern synthetic colloidal plasma substitutes.
Sometimes, according to reviews, against the background of the use of the drug, the appearance of allergic reactions, an increase / decrease in blood pressure, tachycardia was noted.
Albumin price in pharmacies
The price of Albumin can be:
- 5% solution for infusion: 100 ml - 1250 rubles;
- 10% solution for infusion: 50 ml - 1500-1750 rubles, 100 ml - 1550-2150 rubles;
- 20% solution for infusion: 50 ml - 2420-2750 rubles, 100 ml - 3450-4500 rubles.
Albumin: prices in online pharmacies
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Drug name Price Pharmacy |
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Albumin 10% solution for infusion 100 ml 1 pc. 1596 RUB Buy |
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Human albumin 20% solution for infusion 50 ml 1 pc. RUB 1,750 Buy |
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Albumin 20% solution for infusion 50 ml 1 pc. 1863 RUB Buy |
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Albumin 10% solution for infusion 100 ml 1 pc. 1899 RUB Buy |
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Human albumin 20% solution for infusion 50 ml 1 pc. 1950 RUB Buy |
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Uman albumin 25% solution for infusion 50 ml 1 pc. 3234 RUB Buy |
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Albumin 20% solution for infusion 100 ml 1 pc. 3599 RUB Buy |
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Human albumin 20% solution for infusion 100 ml 1 pc. 4250 RUB Buy |
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Human albumin 20% 20% solution for infusion 100 ml 1 pc. 4298 RUB Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
