Agesta - Instructions For Use, Indications, Doses, Analogues

2023 Author: Rachel Wainwright | [email protected]. Last modified: 2023-08-25 01:36

Agesta

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Analogs
9. 9. Terms and conditions of storage
10. 10. Terms of dispensing from pharmacies

Agesta is an antigestogenic synthetic steroid drug.

Release form and composition

Dosage form - tablets (1 or 2 pcs. In polymer cans, in a cardboard box 1 can; 1 or 2 pcs. In a blister strip, in a cardboard box 1 package).

The active ingredient of Agesta is mifepristone, in 1 tablet - 10 mg.

Indications for use

• Interruption of uterine pregnancy in the early stages (in the absence of menstruation up to 42 days);
• Induction of labor at full-term pregnancy;
• Emergency contraception, one-time prevention of unwanted pregnancy after unprotected intercourse;
• Leiomyoma of the uterus, the size of which does not exceed 12 weeks of pregnancy.

Contraindications

• Acute and chronic form of renal and / or hepatic failure;
• Adrenal insufficiency, long-term glucocorticosteroid therapy;
• Porphyria;
• Diseases of the female reproductive system of inflammatory etiology;
• The presence of a scar on the uterus;
• Severe forms of extragenital pathologies (without prior consultation with a therapist);
• Anemia;
• Violation of hemostasis (including against the background of previous use of anticoagulants);
• Smoking in patients over the age of 35;
• Individual intolerance to the drug.

In addition, Agesta cannot be used for certain types of clinical indications in the presence of the following pathologies:

• Termination of pregnancy: suspicion of an ectopic pregnancy, a pregnancy period of more than 42 days after the cessation of menstruation, pregnancy not confirmed by clinical studies, pregnancy that occurred after hormonal contraception was canceled or against the background of the use of intrauterine contraceptives, uterine fibroids;
• Preparation and induction of labor: premature or post-term pregnancy, severe preeclampsia, uterine myoma, eclampsia, preeclampsia;
• Treatment of uterine leiomyoma: endometrial hyperplasia and / or ovarian tumors, submucous localization of myoma nodes, the period of pregnancy and breastfeeding, as well as if the size of the leiomyoma exceeds 12 weeks of pregnancy.

Method of administration and dosage

The tablets are taken orally.

The dose and regimen of administration is prescribed by the doctor depending on the clinical indications.

Recommended dosage:

• Medical termination of pregnancy: 600 mg once with 100 ml of water (1-1.5 hours after meals). To enhance the effect, 400 mg of misoprostol is prescribed simultaneously. The procedure is carried out in the presence of a doctor and it is necessary to monitor the patient's condition within 2 hours after taking the drugs. After 36-48 hours, a control ultrasound examination (ultrasound) is required. To confirm a spontaneous miscarriage after 1-2 weeks, the level of chorionic gonadotropin should be determined, an ultrasound scan and a clinical examination should be repeated;
• Preparation and induction of labor: under the supervision of a physician - 200 mg once, then after 24 hours, 200 mg should be repeated. Assessment of the state of the birth canal is carried out after 48-72 hours, if necessary, the appointment of prostaglandins or oxytocin is possible;
• Postcoital contraception (regardless of the phase of the menstrual cycle): 10 mg once, 2 hours before or 2 hours after eating within the next 72 hours after unprotected intercourse;
• Treatment of uterine leiomyoma: 50 mg 1 time per day for 12 weeks.

Side effects

Common adverse events associated with the use of Agesta can be: hyperthermia, weakness, discomfort in the lower abdomen, headache, nausea, vomiting, dizziness, diarrhea, skin rashes.

In addition, the drug can additionally cause side effects associated with taking it for certain indications:

• Termination of pregnancy: pain in the lower abdomen, bleeding, exacerbation of infectious pathologies of the urinary tract and uterus, inflammation of the uterus and appendages; with the simultaneous appointment of misoprostol (additionally) - insomnia, dyspepsia, vaginitis, fainting, asthenia, anxiety, anemia, leg pain, leucorrhoea, a slight decrease in hemoglobin levels;
• Emergency contraception: spotting, menstrual irregularities;
• Leiomyoma treatment: amenorrhea, menstrual irregularities.

special instructions

The use of Agesta for termination of pregnancy and preparation of childbirth is carried out only in a hospital setting, in the presence of resuscitation equipment, in the presence of a highly qualified doctor.

The action of the drug can cause profuse uterine bleeding, requiring immediate surgery. Care should be taken when prescribing synthetic prostaglandins.

Before starting to take the drug for the purpose of terminating pregnancy, the patient should be informed that in case of ineffectiveness of drug therapy, an operative termination of pregnancy will be required. In case of incomplete abortion or ongoing pregnancy on the 14th day after taking Agesta, vacuum aspiration is performed, followed by a thorough histological examination of the aspirate. The drug is prescribed after all accompanying abortion measures, including the prevention of Rh alloimmunization.

Breastfeeding is contraindicated within 14 days of using mifepristone.

With infective endocarditis and women with artificial heart valves, taking the drug should be accompanied by prophylactic antibiotic therapy.

It is not recommended to use Agesta as a regular scheduled contraception. The drug does not protect against sexually transmitted diseases, including HIV infection.

Drug interactions

It is necessary to increase the dose of glucocorticosteroids when used simultaneously with Agesta.

Analogs

Analogues of Agesta are: Ginepristone, Ginestril, Zhenale, Miropriston.

Terms and conditions of storage

Keep out of the reach of children.

Store at temperatures up to 25 ° C, protected from light and moisture.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!