Fosfonziale
Fosfontsiale: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Phosphonciale
ATX code: A05C
Active ingredient: phospholipids and silimar (phospholipides and silimar)
Producer: CJSC "Kanonfarma production" (Russia)
Description and photo update: 2018-24-10
Prices in pharmacies: from 300 rubles.
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Fosfontsiale is a combined medicinal product based on natural ingredients used in the treatment of liver and biliary tract diseases.
Release form and composition
Fosfontsiale is produced in the form of capsules: size No. 0, gelatinous, pale orange; the contents of the capsules are a yellow-brown loose mass with a specific odor; with light pressure, individual agglomerates stick together into a dense mass (10 pieces in a blister, 3 or 6 packs in a cardboard box; 15 pieces in a blister, 2 or 4 packages in a cardboard box).
1 capsule contains:
- active ingredients: lipoid C100 (essential phospholipids) - 200 mg (equivalent to phosphatidylcholine in an amount of 188 mg), silymar - 70 mg (equivalent to silibinin in an amount of 50 mg);
- additional components: povidone (Kollidon 90F), colloidal silicon dioxide (aeroperl 300), magnesium stearate, calcium phosphate dihydrate, trehalose dihydrate;
- capsule shell: titanium dioxide, gelatin, sunset yellow dye.
Pharmacological properties
Pharmacodynamics
Fosfonziale is a combined agent used to treat diseases of the liver and bile ducts. The drug reproduces the pharmacological effects of its active substances - milk thistle flavolignans (in terms of silibinin) and essential phospholipids.
The hepatoprotective agent acts as follows:
- stimulates protein production;
- normalizes the metabolism of phospholipids, proteins and lipids;
- helps to improve the functional state of the liver and enhance its detoxification function;
- participates in the process of activation and protection of phospholipid-dependent enzyme systems;
- promotes the preservation of hepatocytes and helps to restore their damaged structure;
- prevents the formation of connective tissue in the liver;
- shows a choleretic effect in the presence of cholestasis.
Indications for use
According to the instructions, Fosfoncial is recommended for use in combination therapy for the following diseases / conditions:
- fatty degeneration of the liver of various origins (caused by chronic infections, diabetes mellitus);
- hepatitis in acute / chronic form of various nature (including alcoholic and toxic hepatitis);
- cirrhosis of the liver;
- gestosis;
- hepatic coma;
- psoriasis (as an adjuvant therapy);
- radiation sickness;
- drug intoxication, poisoning, liver dysfunction against the background of other somatic diseases;
- lipid metabolism disorders.
Contraindications
A contraindication to taking Fosfoncial is the presence of hypersensitivity to any of its components.
In view of the existing probability of manifestation of the estrogen-like effect of silymar, the drug should be used with extreme caution in case of hormonal disorders, such as carcinoma of the prostate gland, carcinoma of the uterus, ovaries, breast, uterine myoma, endometriosis.
It is not recommended to use the drug during pregnancy and lactation.
Instructions for use Fosfontsiale: method and dosage
Fosfontiale is taken orally with food. The capsules should be swallowed whole and washed down with plenty of water.
Recommended dosing regimen based on indications:
- fatty degeneration of the liver of various origins, hepatitis of non-viral etiology, cirrhosis of the liver: 2–3 times a day, 2 capsules, course - at least 3 months, if necessary, the attending physician may increase the duration of the course or appoint a second one;
- hepatitis of viral etiology (especially hepatitis B and C): 2-3 times a day, 2 capsules before or during meals, the course is up to 12 months;
- preeclampsia (accompanied by predominant liver damage, HELLP syndrome, hepatosis): 2-3 times a day, 2-3 capsules, course - from 10 to 30 days;
- psoriasis (as part of a combination treatment): 3 times a day, 1-2 capsules, course - from 14 to 40 days;
- drug intoxication, poisoning: 2–3 times a day, 2 capsules, course - 30–40 days;
- functional disorders of the liver, disorders of lipid metabolism: 3 times a day, 1-2 capsules, the duration of admission is determined by the doctor;
- chronic intoxication, including those caused by work in hazardous industries, long-term intake of medicines, alcohol (for prevention purposes): 2-3 times a day, 1 capsule, the duration of use can vary from 1 to 3 months.
Fosfontiale should be taken on the advice of your doctor.
Side effects
Against the background of therapy, in some cases, there may be undesirable effects in the form of gastralgia, nausea, and allergic reactions.
Overdose
There is no information about an overdose of Fosfoncial. If you suspect this condition, induce vomiting, perform gastric lavage, take activated charcoal and, if necessary, symptomatic drugs.
special instructions
There are no special indications regarding the use of the drug.
Influence on the ability to drive vehicles and complex mechanisms
The hepatoprotective agent does not affect the ability to control complex, potentially dangerous machinery (including vehicles).
Application during pregnancy and lactation
Fosfoncial is not recommended for pregnant and breastfeeding women.
Drug interactions
Since silymar is able to exhibit an inhibitory effect on the cytochrome P 450 system, when Fosfoncial is taken in combination with drugs such as ketoconazole, diazepam, vinblastine, alprazolam, lovastin, an increase in the plasma concentration of the latter in the blood may be observed.
Analogs
Fosfontsiale analogs are: Essliver, Eslidin, Essential phospholipids, Liventsiale, Essentiale N, Antraliv, Esslial forte, Livolife Forte, Brenziale forte, Rezalut Pro, Lipoid PPL 400.
Terms and conditions of storage
Store out of the reach of children and protected from light and moisture, at a temperature not exceeding 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Fosfoncial
Reviews of Fosfoncial are overwhelmingly positive. Patients who have taken hepatoprotector note its high efficiency, natural composition, the minimum list of contraindications to its use and the rare development of adverse reactions. The drug restores the liver, improves digestion. According to reviews, after undergoing a course of therapy, many patients significantly improved their condition, including fatigue disappeared, and severity in the epigastrium also disappeared.
The disadvantages of the drug include the need for a long course of treatment with a daily intake of up to 6 capsules. In some cases, dissatisfaction with the rather high cost of the drug is expressed, especially with a full course of therapy.
Price on Fosfoncial in pharmacies
The price of Fosfoncial can be approximately (for 30 capsules per package) from 400 to 470 rubles.
Fosfontiale: prices in online pharmacies
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Drug name Price Pharmacy |
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Fosfontsiale Mono 250 mg / 5 ml solution for intravenous administration 5 ml 5 pcs. RUB 300 Buy |
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Fosfoncial capsules 30 pcs. RUB 315 Buy |
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Fosfoncial capsules 30 pcs. 425 RUB Buy |
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Fosfontsiale Mono solution for intravenous injection. 250mg / 5ml 5 pcs. 431 r Buy |
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Fosfoncial capsules 90 pcs. 630 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
