Table of contents:
- pharmachologic effect
- Indications for use
- Side effects of Flutamide
- special instructions
- Interaction of Flutamide with other drugs
- Flutamide release form
- Storage conditions
- Flutamide: prices in online pharmacies
Video: Flutamide - Instructions For Use, Reviews, Indications
2023 Author: Rachel Wainwright | [email protected]. Last modified: 2023-08-25 01:36
Instructions for use:
- 1. Pharmacological action
- 2. Indications for use
- 3. Instruction
- 4. Side effects
- 5. Contraindications
- 6. Special instructions
- 7. Interaction with other medicinal products
- 8. Overdose
- 9. Release form
- 10. Storage conditions
Prices in online pharmacies:
from 595 rub.
Flutamide is an anticancer drug with antiandrogenic activity.
Flutamide prevents the binding of male sex hormones (androgens), including dihydrotestosterone, to cell receptors. As a result, in androgen-sensitive tumors, for example, in the tissues of tumors of the prostate gland, an obstacle arises for the manifestation of the biological effect of androgens. According to reviews, Flutamide does not possess antigestagenic, progestogenic, antiestrogenic and estrogenic activity.
The drug is quickly and well absorbed from the digestive system. Its maximum concentration in the blood is noted two hours after ingestion. The half-life is five hours. It is excreted in the form of metabolites mainly by the kidneys.
Indications for use
According to the instructions, Flutamide is used for the palliative treatment of prostate cancer with distant metastases in patients who have not previously received any treatment for this pathology.
According to reviews, Flutamide can also be used to treat patients who have not been able to achieve a positive effect during hormone therapy, as well as for those who have developed resistance to it (resistance).
The drug can be used in combination with other antineoplastic agents or for monotherapy.
This drug is prescribed 1 tablet (250 mg) three times a day. The course of treatment should be long. During therapy, it is necessary to regularly examine liver function.
With extreme caution, Flutamide should be prescribed to patients suffering from cardiovascular diseases.
According to the instructions, Flutamide can be used for differential diagnosis of hypogonadism in men. In this case, the drug is prescribed at the rate of 10 mg per kg of the patient's body weight per day. It is taken three times a day for three days. Then a study of the concentration of gonadotropins in the blood serum is performed.
Side effects of Flutamide
Flutamide is generally well tolerated. With prolonged therapy, men may develop gynecomastia, soreness in the mammary glands, fluid retention in the tissues of the body. According to reviews, Flutamide rarely causes complications such as thromboembolism, insomnia, lupus-like syndrome, liver and gastrointestinal tract dysfunctions, and headache.
In the instructions for Flutamide, it is noted: during treatment with it, the patient may experience a slight increase in the blood of methemoglobin (a form of hemoglobin that cannot carry oxygen). This condition is transient and does not require any treatment or discontinuation of Flutamide.
The use of this drug is contraindicated for the treatment of patients suffering from severe diseases of the thyroid gland, kidneys and liver.
Flutamide treatment should be carried out under regular monitoring of liver enzyme activity. A blood test should be done at least once a month. If the patient has an increase in the level of liver enzymes two or more times, and / or jaundice appears (provided that there are no liver metastases), then the drug is immediately canceled.
Patients should immediately consult a doctor at the first signs of liver dysfunction - yellowness of the mucous membranes and skin, itching, dark urine, aversion to food, nausea, vomiting, flu-like syndrome, soreness in the right hypochondrium.
Interaction of Flutamide with other drugs
Flutamide enhances the anticoagulant effect of indirect anticoagulants (Flutamine, Warfarin). Therefore, with the joint appointment of these drugs, the dose should be selected individually, under the control of a coagulogram.
In case of an overdose of Flutamide, it is necessary to flush the stomach. There is no specific antidote, therefore, symptomatic therapy is carried out, aimed at maintaining vital functions.
Flutamide release form
Flutamide is available in the form of tablets containing 250 mg of the active substance. This drug is also available under other names: Norex, Gibitron, Fulforel, Fugirel, Euleksin, Euflex, Drogenil, Cebatrol, Flucin, Flucin.
Flutamide belongs to list B. It is stored at room temperature out of the reach of children. The shelf life is three years. After the expiration date, the drug cannot be used. Dispensed from pharmacies only with a doctor's prescription.
Flutamide: prices in online pharmacies
Flutamide 250 mg film-coated tablets 20 pcs.
Flutamide 250 mg film-coated tablets 84 pcs.
Flutamide 250 mg film-coated tablets 84 pcs.
Flutamide tablets p.o. 250mg 84 Pcs.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
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