Elbona
Elbona: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Elbona
ATX code: M01AX05
Active ingredient: glucosamine (glucosamine)
Manufacturer: Ellara MC (Russia), PharmVILAR NPO (Russia), Moscow Pharmaceutical Factory (Russia)
Description and photo updated: 20.11.2018
Prices in pharmacies: from 859 rubles.
Buy
Elbona is a stimulator of cartilage tissue repair.
Release form and composition
- solution for intramuscular (i / m) administration: clear, colorless or light yellow liquid [2 ml in ampoules made of light-protective glass, complete with solvent * (1 ml in an ampoule made of neutral glass), 6 ampoules with the drug and 6 ampoules with solvent in a blister strip or 6 ampoules with a drug in a blister and 6 ampoules with a solvent in a blister, in a cardboard box 1 blister with a drug and a solvent or 1 pack with a drug and 1 pack with a solvent];
- powder for preparation of solution for oral administration: white or yellowish-white color (2.2 g each in heat-sealable bags, 20 bags in a cardboard box).
* Solvent is a clear, colorless liquid. Composition of 1 ampoule: diethanolamine and water for injection.
Composition of 1 ampoule of the drug:
- active substance: glucosamine sulfate sodium chloride - 502.5 mg, which is equivalent to 400 mg of glucosamine sulfate and 102.5 mg of sodium chloride;
- auxiliary components: lidocaine hydrochloride, trometamol, water for injection.
Composition of 1 package of powder:
- active ingredient: glucosamine sulfate sodium chloride - 1884 mg, including 1500 mg glucosamine sulfate;
- auxiliary components: citric acid, sorbitol.
Pharmacological properties
Pharmacodynamics
Glucosamine sulfate is an active component of Elbona - a substance that stimulates the process of cartilage tissue repair, has anesthetic and anti-inflammatory effect. Replenishes endogenous glucosamine deficiency, stimulates the synthesis of hyaluronic acid and proteoglycans of synovial fluid. Promotes the fixation of sulfur in the synthesis of chondroitinsulfuric acid. Restores enzymatic processes in the cells of the synovial membrane and articular cartilage. Increases the permeability of the joint capsule. It inhibits the development of degenerative processes in the joints and restores their function.
Thus, Elbona prevents the destruction of cartilage, promotes the restoration of cartilage tissue, improves joint mobility and reduces joint pain, as a result of which it also reduces the need for non-steroidal anti-inflammatory drugs (NSAIDs).
Pharmacokinetics
When taken orally, glucosamine sulfate is absorbed by 90% from the gastrointestinal tract. Bioavailability is 26%, half-life is 70 hours.
Pharmacokinetic studies show that intramuscular administration of the drug easily achieves those concentrations of glucosamine sulfate in the joint cavity for which an effective pathogenetic effect on chondrocytes and extracellular matrix components in patients with osteoarthritis has been proven.
Injection of the drug three times a week at 400 mg for a 6-week course leads to a clinically proven improvement in patients with knee osteoarthritis compared with placebo. Thanks to intramuscular injection, it is possible to quickly achieve an analgesic and anti-inflammatory effect, as well as prevent the progression of osteoarthritis, as a result of which the need for arthroplasty is reduced.
Indications for use
- primary and secondary osteoarthritis of the joints of the spine and peripheral joints;
- spondyloarthrosis.
Contraindications
For both dosage forms of Elbona:
- pregnancy and lactation;
- children under 12 years old;
- severe renal impairment;
- hypersensitivity to any component of the drug.
Additionally, for a solution for intramuscular injection (including due to the presence of lidocaine in the composition):
- phenylketonuria;
- a history of epileptiform seizures;
- acute heart failure;
- violation of cardiac conduction;
- severe liver dysfunctions.
According to the instructions, Elbon should be used with caution in the following cases:
- diabetes;
- bronchial asthma;
- intolerance to seafood;
- arterial hypotension (solution for intramuscular injection);
- chronic heart failure (solution for intramuscular injection).
Instructions for the use of Elbona: method and dosage
Solution for i / m administration
In this dosage form, Elbona is intended exclusively for intramuscular administration.
Before use, the ampoule with the drug (2 ml) is mixed with the ampoule of the solvent (1 ml) in one syringe.
The prepared solution is administered in 1 dose (total - 3 ml) three times a week for 4–6 weeks.
Powder for oral solution
In this dosage form, Elbona is taken orally, after dissolving the contents of one packet in 200 ml of water.
The recommended dosage is 1 sachet once a day for 6 weeks.
According to the doctor's prescription, it is possible to carry out repeated courses of treatment at intervals of 2 months.
Side effects
Elbona is generally well tolerated. In some cases, the following side effects are noted: flatulence, constipation or diarrhea, gastralgia, allergic reactions (itching, urticaria).
With the i / m administration of the drug due to the content of lidocaine in the solution, the following may occur: numbness of the tongue and mucous membrane of the mouth, nausea, vomiting, headache, drowsiness, dizziness, disorientation, tremor, diplopia, euphoria, anaphylactic reactions, impaired cardiac conduction.
Overdose
Overdose cases were not noted.
When ingestion of a dose significantly higher than that prescribed by the doctor, it is recommended to perform gastric lavage. Further treatment is symptomatic.
special instructions
In patients with intolerance to seafood (for example, shrimp or shellfish), the risk of allergic reactions increases when using Elbona.
Solution for intramuscular administration is prohibited to be administered intravenously.
Application during pregnancy and lactation
Elbona is not recommended for pregnant and breastfeeding women.
Pediatric use
The use of the drug is contraindicated in children under 12 years of age.
With impaired renal function
Elbona is contraindicated in severe renal impairment.
For violations of liver function
Solution for intramuscular injection is contraindicated in severe hepatic impairment.
Drug interactions
Glucosamine sulfate is compatible with paracetamol, glucocorticosteroids and non-steroidal anti-inflammatory drugs.
With the simultaneous use of quinidine, verapamil, phenytoin, amiodarone, aymaline, there is a possibility of an increase in the negative inotropic effect.
The joint appointment of beta-blockers increases the risk of bradycardia.
Glucosamine sulfate increases the muscle action of curariform drugs. Potentiates the effects of monoamine oxidase inhibitors. May enhance the depressing effect on the central nervous system of hypnotics and sedatives. Reduces the cardiotonic effect of cardiac glycosides. May reduce the effectiveness of antidiabetic drugs, teniposide, doxorubicin, etoposide.
With the simultaneous use of procainamide, the risk of developing hallucinations and arousal of the central nervous system increases.
Propranolol and cimetidine decrease hepatic clearance of lidocaine and increase the risk of toxic effects.
In the case of a combination of Elbona with polymyxin B, the inhibitory effect on neuromuscular transmission may increase. If the combined use of drugs is justified, you should carefully monitor the patient's respiratory function.
With intravenous administration of sodium thiopental or hexobarbital, respiratory depression is possible (against the background of the action of lidocaine).
When taken orally, Elbon reduces the absorption of chloramphenicol and semi-synthetic penicillins, increases the absorption of tetracyclines.
Analogs
Elbona's analogues are: Artrakam, Glucosamine, Glucosamine sulfate 750, DONA, Sustagard Artro, Sustilak, Chondroxide Maximum.
Terms and conditions of storage
Store no more than 2 years from the date of production in a place protected from moisture and light at temperatures up to 25 ° C.
Keep out of the reach of children.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Elbon
Reviews about Elbon are positive: it effectively relieves pain, reduces joint stiffness and improves their mobility, and also significantly reduces the need for NSAIDs. In addition, patients note the painlessness of injections, the rapid onset of the effect (compared with the use of chondroprotectors), as well as the presence of a parenteral dosage form, which is especially important for patients who have side effects from the liver and gastrointestinal tract against the background of prolonged use of NSAIDs. … Additional advantages include the convenience of using the drug (3 times a week) and the short duration of the course of treatment (only 2 months).
Some patients consider Elbona's disadvantage only that it is not sold in all pharmacies.
Elbona price in pharmacies
The price for Elbona is approximately 1055-1260 rubles. for a pack of 6 ampoules (complete with 6 ampoules of solvent). The cost of the powder for the preparation of a solution for oral administration is currently unknown, since the drug in this dosage form is not available in pharmacies.
Elbona: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Elbona 200 mg / ml solution for intramuscular administration complete with solvent 2 ml 6 pcs. 859 r Buy |
|
Elbon solution in / m introduction. 200mg / ml ampoule (a) 2ml 12 pcs. (complete with solvent ampoule (b) 1ml 12 pcs.) 1123 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
