Trimedat forte
Trimedat forte: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Trimedat forte
ATX code: A03AA05
Active ingredient: trimebutin (Trimebutine)
Manufacturer: PJSC "Valenta Pharmaceuticals" (Russia)
Description and photo update: 2019-08-07
Prices in pharmacies: from 518 rubles.
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Trimedat forte is an antispasmodic, a universal regulator of the motility of the digestive system, acting on all parts of the digestive tract.
Release form and composition
The drug is available in the form of tablets with prolonged release, film-coated: round, biconvex, white, engraved on one side in the form of a symbolic image of two drop-shaped elements, the core of the tablet is white or almost white (10 pcs. In blisters, in a cardboard box 1, 2 or 6 packages and instructions for use of Trimedat forte).
1 tablet contains:
- active substance: trimebutine maleate - 300 mg;
- auxiliary components: microcrystalline cellulose, hypromellose, povidone K-25, magnesium stearate;
- the composition of the film shell (Opadray II 85F18422): partially hydrolyzed polyvinyl alcohol, macrogol-3350, titanium dioxide (E171), talc.
Pharmacological properties
Pharmacodynamics
Trimedat forte is an antispasmodic drug. The action of its active substance, trimebutin, is aimed at restoring the normal physiological activity of the intestinal musculature in various diseases of the gastrointestinal tract (GIT) caused by motility disorders.
Trimebutin directly affects the enkephalinergic (opiatergic) system of the intestine, contributing to the regulation of its peristalsis. The myotropic antispasmodic regulates the motility of the entire gastrointestinal tract, acting on peripheral delta (δ) -, mu (μ) - and kappa (k) -receptors, including those located directly on smooth muscles, without affecting the central nervous system.
The drug normalizes visceral sensitivity, which in case of abdominal pain syndrome provides its analgesic effect.
Pharmacokinetics
After oral administration, the absorption of trimebutin from the gastrointestinal tract occurs quickly. Plasma protein binding is about 5%. The substance penetrates the placental barrier to an insignificant extent. In the liver, the biotransformation of trimebutin ends with the formation of metabolites, which are subsequently excreted through the kidneys.
The pharmacokinetic parameters of the active metabolite of trimebutin - 2-methylamino-2-phenylbutyl-3,4,5-trimethoxybenzoate (desmethyltrimmebutin), after a single dose of Trimedat forte by healthy volunteers have the following values: maximum concentration (Cmax) - from 188.46 to 694.44 ng / ml (time to reach - 1.19-3.21 hours); MRT (mean retention period in the body) - 17.12 ± 3.14 hours; T 1/2 (half-life) - 8-18 hours; Vd (volume of distribution) varies widely from 171.19 to 2388.25 liters; total clearance - 32.17-100.85 l / h.
Indications for use
The use of Trimedat forte is indicated for such functional disorders of the gastrointestinal tract and biliary tract as a non-erosive form of gastroesophageal reflux disease, irritable bowel syndrome, dysfunction of the biliary tract, cholelithiasis, postcholecystectomy syndrome, dysfunction of the sphincter of Oddi. The drug is prescribed for the symptomatic treatment of spasms, pain, discomfort in the abdomen, elimination of flatulence (bloating sensation), intestinal motor disorders, accompanied by changes in stool frequency (diarrhea / constipation), nausea or vomiting, belching, heartburn, dyspepsia.
In addition, Trimedat forte is used for postoperative paralytic intestinal obstruction.
Contraindications
- period of pregnancy;
- lactation period;
- age up to 12 years;
- hypersensitivity to the components of the drug.
Trimedat forte, instructions for use: method and dosage
Trimedat forte tablets are taken orally.
Recommended dosage for patients over the age of 12 years: 1 pc. 2 times a day, at intervals of 12 hours.
The duration of the course of treatment for abdominal pain caused by functional pathologies of the digestive tract or biliary tract is 28 days.
Side effects
- from the digestive system: nausea, dry mouth, dyspepsia, perversion of taste, diarrhea, constipation;
- from the nervous system: anxiety, drowsiness, fatigue, headache, dizziness;
- from the immune system: skin rash;
- other reactions: urinary retention, menstrual irregularities, painful enlargement of the mammary glands.
Overdose
Overdose symptoms have not been established.
Trimebutin does not have a specific antidote, therefore, while taking a high dose of Trimedat Forte, you should immediately wash the stomach and take activated charcoal. Then stop taking the drug and, if necessary, carry out symptomatic therapy.
special instructions
In the period of remission after the completion of the course of treatment, in order to prevent the recurrence of irritable bowel syndrome, it is recommended to continue taking the tablets for 12 weeks at a dose of 300 mg (1 pc.) Per day.
Before using the drug, you should consult a specialist.
Influence on the ability to drive vehicles and complex mechanisms
During the period of application of Trimedat forte, care should be taken when performing potentially hazardous activities, including driving vehicles and mechanisms, due to the existing risk of dizziness in the patient.
Application during pregnancy and lactation
In experimental studies, teratogenicity and embryotoxicity of trimebutin were not identified. But since there is no required amount of clinical observation data, the use of Trimedat forte tablets during the gestation period is contraindicated.
If you need to use the drug during lactation, you should stop breastfeeding.
Pediatric use
The appointment of trimebutin in the form of extended-release film-coated tablets for the treatment of children under the age of 12 is contraindicated.
Drug interactions
Data on drug interactions of Trimedat forte with other substances / drugs are not provided by the manufacturer.
Analogs
The analogs of Trimedat forte are Trimedat, Trimedat Valenta, Neobutin, Neobutin Retard, Tribudat, Tribuks, Trimspa, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Trimedat Fort
Currently, there are practically no reviews of Trimedat forte from patients, since this drug is a novelty of the Trimedat brand and has entered the market quite recently. At the same time, experts say that thanks to the form of release (prolonged release of the substance), the drug has become even more convenient. And the triple mechanism of action helps to eliminate abdominal pain, heaviness, bloating and stool disturbances.
Price for Trimedat forte in pharmacies
The price of Trimedat forte for a package containing 30 tablets can range from 633 rubles.
Trimedat forte: prices in online pharmacies
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Drug name Price Pharmacy |
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Trimedat forte 300 mg film-coated tablets with prolonged release 20 pcs. RUB 518 Buy |
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Trimedat Forte tablets p.p. with prolonged release. 300mg 20 pcs. RUB 528 Buy |
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Trimedat forte 300 mg film-coated tablets with prolonged release 60 pcs. 1102 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
