Trimectal
Trimectal: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Trimektal
ATX code: C01EB15
Active ingredient: trimetazidine (trimetazidine)
Manufacturer: CJSC "Vertex" (Russia)
Description and photo update: 2018-25-10
Prices in pharmacies: from 371 rubles.
Buy
Trimectal is an antihypoxic agent that improves the metabolism of myocardial cells and neurosensory organs during ischemia.
Release form and composition
Trimectal is produced in the form of capsules: size No. 3, hard gelatinous, white / orange; the contents of the capsules are white or almost white powder (10 pieces in a blister contour package, in a cardboard box 6 packs; 20 pieces in a blister contour package, in a cardboard box 3 packages; 60 pieces in a polymer can, in a cardboard box 1 can) …
Composition for 1 capsule:
- active substance: trimetazidine dihydrochloride - 20 mg;
- additional components: calcium stearate (octadecanoate), povidone (polyvinylpyrrolidone), corn starch, lactose;
- capsule shell: solar yellow dye (E110), azorubin (E122), gelatin, titanium dioxide (E171).
Pharmacological properties
Pharmacodynamics
Trimectal is an antianginal and antihypoxic agent. The active substance of the drug, having a direct effect on the neurons of the brain and cardiomyocytes, ensures their optimal functioning and improves metabolism. The cytoprotective effect demonstrated by trimetazidine is due to an increase in the energy potential, an increase in the activity of the oxidative decarboxylation process, and an improvement in oxygen consumption (by blocking fatty acid oxidation and enhancing aerobic glycolysis).
Providing normal myocardial contractility, the agent counteracts the decrease in the intracellular volume of ATP and phosphocreatine. Against the background of acidosis, due to the effect of trimetazidine, the functions of membrane ion channels and the intracellular level of potassium ions are normalized, and there is no accumulation of calcium and sodium in cardiomyocytes. The drug reduces the concentration of phosphates and intracellular acidosis associated with ischemia of the heart muscle and reperfusion. By preventing the negative action of free radicals, it helps to maintain the integrity of cell membranes.
Trimectal does not allow activation of neutrophils in the ischemic zone, promotes an increase in the duration of the electrical potential, a decrease in the severity of ischemic damage to the myocardium and the release of creatine phosphokinase from cells. Leading to a decrease in the frequency of angina attacks, the drug reduces the need for taking nitrates, 14 days after the start of the course, it reduces fluctuations in blood pressure (BP) and increases exercise tolerance.
Against the background of trimetazidine therapy, there is an improvement in the results of vestibular tests and hearing acuity, a decrease in tinnitus and dizziness. With vascular diseases of the eyes, the functional activity of the retina is restored.
Pharmacokinetics
After oral administration, trimetazidine is rapidly and almost completely absorbed from the gastrointestinal tract (GIT). Bioavailability is 90%, the period of reaching the maximum concentration of the agent (C max) in blood plasma is 2 hours. With a single dose of 20 mg of the drug, C max can be approximately equal to 55 ng / ml. The agent passes easily through the histohematogenous barriers.
The binding of trimetazidine to plasma proteins is no more than 16%, the half-life (T ½) is 4.5–5 hours. It is excreted by the kidneys, unchanged - about 60%.
Indications for use
- ischemic heart disease (CHD) - prevention of angina attacks (as part of combination therapy);
- dizziness of vascular origin;
- chorioretinal vascular disorders;
- cochleo-vestibular disorders of the ischemic nature (hearing impairment, tinnitus).
Contraindications
- severe functional disorders of the liver;
- renal failure;
- age up to 18 years;
- pregnancy and the period of breastfeeding;
- hypersensitivity to the constituents of Trimectal.
Instructions for use of Trimectal: method and dosage
Trimectal is taken orally with meals.
The recommended daily dose is 40-60 mg (2-3 capsules), divided into 2-3 doses. The duration of drug use is determined by the attending physician individually.
Side effects
- digestive system: rarely - vomiting, nausea, gastralgia;
- cardiovascular system: palpitations;
- central nervous system: rarely - headache;
- allergic reactions: itchy skin.
Overdose
Until now, no cases of drug overdose have been recorded.
special instructions
During treatment with trimetazidine dihydrochloride in patients with coronary artery disease, there was a significant decrease in the daily requirement for taking nitrates.
The drug is not intended to relieve angina attacks.
Trimectal is not used in the initial course of therapy for myocardial infarction and unstable angina pectoris.
Influence on the ability to drive vehicles and complex mechanisms
Trimectal does not adversely affect the ability to drive potentially dangerous and complex mechanisms, including vehicles.
Application during pregnancy and lactation
According to the instructions, Trimectal is contraindicated to take during pregnancy and lactation.
Pediatric use
It is prohibited to use Trimectal in patients under 18 years of age, since the safety and effectiveness of its use in children and adolescents have not been established.
With impaired renal function
In the presence of renal failure (creatinine clearance less than 15 ml / min), drug treatment is contraindicated.
For violations of liver function
In the presence of severe liver dysfunctions, Trimectal is contraindicated.
Drug interactions
There is no information on the interaction of trimetazidine with other drugs.
Analogs
Analogs of Trimectal are: Angiosil retard, Vero-Trimetazidine, Antisten, Deprenorm MV, Predizin, Medarum 20, Preductal MV, Trimetazidin MV, Preductal OD, Trimetazidin-Biocom MV, Precard, Trimet, Trimetazidin, Trimitard MV, Trimetazidin-Rati
Terms and conditions of storage
Store out of the reach of children, protected from moisture and light, at a temperature not exceeding 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Trimektal
Reviews about Trimektal are quite diverse. Since the drug is most often prescribed for the maintenance therapy of coronary artery disease and vascular disorders in combination with drugs used as the main treatment, it is very difficult to determine the positive effect of one of the components of therapy. However, many patients who took the drug, especially in combination with Magne B 6, speak favorably about Trimectal.
There are reviews in which patients indicate a complete lack of effect from the combined therapy of coronary artery disease using the drug. In this case, if it is not possible to achieve a positive clinical response to the main therapy, it is recommended to consult a doctor for an alternative treatment.
There are no reports of the development of serious adverse reactions while taking the drug.
Price for Trimectal in pharmacies
The price of Trimectal can be on average in the range of 300–350 rubles per package containing 60 capsules.
Trimectal: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Trimectal MV 35 mg film-coated tablets with modified release 60 pcs. 371 r Buy |
|
Trimectal MV 35 mg film-coated tablets with modified release 120 pcs. 393 r Buy |
|
Trimectal MV tablets p.o. 35mg 60 Pcs. 482 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
