Triazavirin
Triazavirin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Triazavirin
ATX code: J05AX
Active ingredient: sodium methylthionitrooxodihydrotriazolotriazinide sodium methylthionitrooxodihydrotriazolotriazinide
Manufacturer: Plant Medsintez, LLC (Russia)
Description and photo updated: 2018-23-11
Prices in pharmacies: from 1027 rubles.
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Triazavirin is a direct antiviral drug (not a symptomatic agent and not an immunomodulator); effective against influenza viruses, including avian and swine, as well as ARVI (acute respiratory viral infections) of any etiology; is active at any stage of the disease, and not only at the beginning of infection.
Release form and composition
Triazavirin is available in the form of capsules: size No. 1, hard gelatinous, red cap and yellow body, inside capsules - granules or fine crystalline powder of yellow-green or yellow color (10 pcs. In blisters, in a cardboard box 2 or 5 packs; 20 or 50 pcs. in orange glass jars or polymer jars, in a cardboard box 1 jar or jar).
1 capsule contains:
- active substance: sodium methylthionitrooxodihydrotriazolotriazinide dihydrate (triazavirin) - 250 mg;
- auxiliary component of the capsule contents: calcium stearate;
- capsule body: titanium dioxide (E171), medical gelatin, dyes - sunset yellow (E110), quinoline yellow (E104);
- capsule cap: titanium dioxide (E171), medical gelatin, azorubin (E122).
Pharmacological properties
Pharmacodynamics
Triazavirin is a synthetic analogue of the bases of purine nucleosides (guanine), which have a pronounced antiviral activity against RNA viruses. The mechanism of action of the drug is mainly due to inhibition of the synthesis of viral RNA (ribonucleic acid) and the replication of genomic fragments.
Pharmacokinetics
After oral administration, the active substance is rapidly absorbed in the gastrointestinal tract. The maximum concentration (C max) of triazavirin in blood plasma is reached after 1–1.5 hours and averages 0.0048 mg / ml when taken in a dose of 250 mg 3 times a day.
T 1/2 (half-life) is 1-1.5 hours. Through the kidneys, 15–45% of triazavirin is excreted unchanged. The calculated clearance averages 246 ml / min.
Indications for use
According to the instructions, Triazavirin is indicated for the treatment of influenza in adult patients, including in combination with symptomatic drugs.
Contraindications
- renal failure;
- liver failure;
- period of pregnancy;
- breast-feeding;
- age up to 18 years;
- hypersensitivity to the components of the drug.
Instructions for the use of Triazavirin: method and dosage
Triazavirin capsules are taken orally, regardless of food intake.
Recommended dosage: 1 pc. 3 times a day, the duration of the course of treatment is 5-7 days.
It is necessary to start using the drug after the onset of clinical symptoms of influenza within the first two days.
Side effects
- from the immune system: allergic reactions;
- from the digestive system: nausea, vomiting, flatulence, diarrhea.
Overdose
Overdose symptoms are stomach pain, nausea, vomiting, dyspepsia.
It is recommended to carry out symptomatic therapy, if necessary, to cancel the drug.
special instructions
If any undesirable phenomena occur, you should consult a doctor.
Application during pregnancy and lactation
The use of Triazavirin during gestation and lactation is contraindicated due to the lack of information on the safety and effectiveness of therapy.
If necessary, taking capsules during lactation, breastfeeding should be temporarily stopped.
Pediatric use
The appointment of the drug for the treatment of children and adolescents under the age of 18 is contraindicated.
With impaired renal function
The use of Triazavirin in patients with renal failure is contraindicated.
For violations of liver function
The use of the drug in patients with hepatic insufficiency is contraindicated.
Drug interactions
Simultaneous use with analogues of purine and pyrimidine bases increases the toxicity of the drug.
If necessary, the combination with ribavirin requires a decrease in the usual dose of the latter.
Analogs
Analogs of Triazavirin are Virazol, Viferon, Oxolin, Acyclovir, Zovirax, Tebrofen, Gerpevir, Grippferon, Hyporamine ointment, Ribavirin, Rimantadin.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C, protected from moisture and light.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Triazavirin
In reviews of Triazavirin, patients give a positive assessment of the effectiveness of the drug in the treatment of influenza. They indicate that the use of an antiviral drug from the first days of the disease leads to a full recovery within 5 days and avoids the characteristic severe complications that often occur with influenza. In the case of a timely start of treatment, the disease proceeds with less pronounced symptoms and is not accompanied by a very high body temperature. The capsules are advised to be swallowed whole, as their contents have a very bitter taste.
Price for Triazavirin in pharmacies
The price of Triazavirin for a package containing 20 capsules can range from 946 rubles.
Triazavirin: prices in online pharmacies
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Drug name Price Pharmacy |
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Triazavirin 250 mg capsules 20 pcs. 1027 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
