Thioctacid BV
Thioctacid BV: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Thioctacid
ATX code: A16AX01
Active ingredient: thioctic acid
Manufacturer: GmbH MEDA Manufacturing (Germany)
Description and photo update: 2018-24-10
Prices in pharmacies: from 1633 rubles.
Buy
Thioctacid BV is a metabolic drug with an antioxidant effect.
Release form and composition
Thioctacid BV is produced in the form of film-coated tablets: green-yellow, oblong biconvex (30, 60 or 100 pieces in dark glass bottles, 1 bottle in a cardboard box).
1 tablet contains:
- active substance: thioctic (alpha-lipoic) acid - 0.6 g;
- auxiliary components: magnesium stearate, hyprolose, low-substituted hyprolose;
- composition of the film shell: titanium dioxide, macrogol 6000, hypromellose, aluminum varnish based on indigo carmine and quinoline yellow dye, talc.
Pharmacological properties
Pharmacodynamics
Thioctacid BV is a metabolic drug that improves the trophism of neurons, has hepatoprotective, hypocholesterolemic, hypoglycemic, hypolipidemic effects.
The active ingredient of the drug is thioctic acid, which is found in the human body and is an endogenous antioxidant. As a coenzyme, it participates in the reactions of oxidative phosphorylation of pyruvic acid and alpha-keto acids. The mechanism of action of thioctic acid is close to the biochemical effect of vitamins of group B. It helps to protect cells from the toxic effects of free radicals that arise in metabolic processes, and neutralizes exogenous toxic compounds that have entered the body. By increasing the level of the endogenous antioxidant glutathione, it causes a decrease in the severity of the symptoms of polyneuropathy.
The result of the synergistic action of thioctic acid and insulin is an increase in glucose utilization.
Pharmacokinetics
Absorption of thioctic acid from the gastrointestinal tract (GIT) when taken orally occurs quickly and completely. Taking the drug with meals can reduce its absorption. C max (maximum concentration) in blood plasma after taking a single dose is reached after 30 minutes and is 0.004 mg / ml. The absolute bioavailability of Thioctacid BV is 20%.
Before entering the systemic circulation, thioctic acid undergoes the effect of the first passage through the liver. The main pathways of its metabolism are oxidation and conjugation.
T 1/2 (half-life) is 25 minutes.
The excretion of the active substance Thioctacid BV and its metabolites is carried out through the kidneys. 80–90% of the drug is excreted in the urine.
Indications for use
- diabetic polyneuropathy;
- alcoholic polyneuropathy.
Contraindications
- period of pregnancy;
- breast-feeding;
- children and adolescence;
- hypersensitivity to the components of the drug.
Instructions for the use of Thioctacid BV: method and dosage
According to the instructions, Thioctacid BV 600 mg is taken orally on an empty stomach, 0.5 hours before breakfast, swallowing whole and drinking plenty of water.
Recommended dosage: 1 pc. 1 per day.
Given the clinical feasibility, for the treatment of severe forms of polyneuropathy, it is possible to initially prescribe a solution of thioctic acid for intravenous administration (Thioctacid 600 T) for a period of 14 to 28 days, followed by the transfer of the patient to a daily intake of the drug inside (Thioctacid BV).
Side effects
- from the digestive system: often - nausea; very rarely - vomiting, pain in the stomach and intestines, diarrhea, impaired taste;
- from the nervous system: often - dizziness;
- allergic reactions: very rarely - itching, skin rash, urticaria, anaphylactic shock;
- on the part of the body as a whole: very rarely - a decrease in blood glucose levels, the appearance of symptoms of hypoglycemia in the form of headache, confusion, increased sweating, visual impairment.
Overdose
Symptoms: against the background of a single dose of 10–40 g of thioctic acid, severe intoxication may develop with such manifestations as generalized convulsive seizures, hypoglycemic coma, severe acid-base imbalance, lactic acidosis, severe blood clotting disorders (including fatal).
Treatment: if an overdose of Thioctacid BV is suspected (a single dose for an adult more than 10 tablets, a child - more than 50 mg per 1 kg of his body weight), the patient needs immediate hospitalization with the appointment of symptomatic therapy. If necessary, use anticonvulsant therapy, urgent measures aimed at maintaining the functions of vital organs.
special instructions
Since ethanol is a risk factor for the development of polyneuropathy and causes a decrease in the therapeutic efficacy of Thioctacid BV, alcohol consumption is categorically contraindicated in patients.
When treating diabetic polyneuropathy, the patient should create conditions that ensure the maintenance of optimal blood glucose levels.
Application during pregnancy and lactation
Due to the lack of sufficient experience of use, the appointment of Thioctacid BV is contraindicated during the gestation period and during breastfeeding.
Pediatric use
Since there are no clinical data on the use of Thioctacid BV in children and adolescents, the use of thioctic acid for their treatment is contraindicated.
Drug interactions
With the simultaneous use of Thioctacid BV:
- cisplatin - lowers its therapeutic effect;
- insulin, oral hypoglycemic agents - can enhance their effect, therefore, regular monitoring of blood glucose levels is required, especially at the beginning of combination therapy; if necessary, a decrease in the dose of hypoglycemic drugs is allowed;
- ethanol and its metabolites - cause weakening of the drug.
It is necessary to take into account the property of thioctic acid to bind metals when combined with drugs containing iron, magnesium and other metals. It is recommended to postpone their reception to the second half of the day.
Analogs
Analogs of Thioctacid BV are: Thioctacid 600 T, Alpha-lipon, Berlition, Thiogamma, Dialipon, Thioctic acid, Lipoic acid, Thiolepta, Espalipon, Octolipen.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Thioctacid BV
Reviews of Thioctacide BV are often positive. Patients with diabetes mellitus indicate a decrease in blood sugar and cholesterol levels, good health against the background of long-term use of the drug. A feature of the drug is the rapid release of thioctic acid, which helps to accelerate metabolic processes and the elimination of unsaturated fatty acids from the body, the conversion of carbohydrates into energy.
A positive therapeutic effect is noted when using the drug for the treatment of liver, neurological diseases, obesity. Compared with analogs, patients indicate a lower incidence of unwanted effects.
In some patients, taking the drug did not have the expected effect in lowering cholesterol or contributed to the development of urticaria.
Price for Thioctacid BV in pharmacies
The price of Thioctacid BV 600 mg per package containing 30 tablets can be 1,890 rubles, 60 tablets - 2,145 rubles, 100 tablets - 3,180 rubles.
Thioctacid BV: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Thioctacid BV 600 mg film-coated tablets 30 pcs. 1633 RUB Buy |
|
Thioctacid BV tablets p.o. 600mg 30 pcs. 1857 RUB Buy |
|
Thioctacid BV 600 mg film-coated tablets 100 pcs. RUB 2501 Buy |
|
Thioctacid BV tablets p.o. 600mg 100 pcs. 2553 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
