Naftifin
Naftifin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Prices in pharmacies
Latin name: Naftifine
ATX code: D01AE22
Active ingredient: naftifine (Naftifine)
Producer: LLC "Tula Pharmaceutical Factory" (Russia)
Description and photo update: 09.10.2019
Naftifine is an antifungal drug for external use.
Release form and composition
Dosage forms of the drug:
- solution for external use 1%: transparent colorless or slightly yellow liquid with the smell of ethanol (10, 12, 15, 20 or 30 ml each in dark glass bottles, 1 bottle in a cardboard box);
- cream for external use 1%: white homogeneous shiny mass with a characteristic weak odor (10, 15, 20, 25, 30, 40, 50, 60, 70, 80, 90, 100 g each in aluminum tubes, in a cardboard box 1 tube).
Each pack also contains instructions for the use of Naftifin.
1 ml of solution contains:
- active substance: naftifine hydrochloride - 10 mg;
- auxiliary components: ethanol (ethyl alcohol 95%), propylene glycol, purified water.
1 g of cream contains:
- active substance: naftifine hydrochloride - 10 mg;
- auxiliary components: benzyl alcohol, stearic alcohol, cetyl alcohol, sodium hydroxide, sorbitan stearate, cetyl palmitate, polysorbate 60, isopropyl myristate, purified water.
Pharmacological properties
Pharmacodynamics
Naftifine - an antifungal agent for external use, has an anti-inflammatory effect. The drug belongs to the class of allylamines. The mechanism of its action is due to the ability of the active substance, naftifine, to inhibit squalene-2,3-epoxidase and reduce the formation of ergosterol, which is part of the cell wall of the fungus.
Naftifine is fungicidal against molds [Aspergillus speciales (spp.)] And dermatophytes (including Trichophyton, Microsporum, Epidermophyton). To yeast fungi (Candida spp., Pityrosporum), the drug exhibits fungistatic or fungicidal activity, depending on the strain of the microorganism. In addition, Sporothrix schenckii and other fungi are sensitive to naftifine. It has an antibacterial effect on gram-positive and gram-negative microorganisms, which have the ability to potentiate the development of secondary bacterial infections.
It has an anti-inflammatory effect, due to which it quickly relieves the itching sensation and other symptoms of inflammation.
Pharmacokinetics
When applied externally, Naftifine penetrates well enough into various layers of the skin, creating stable antifungal concentrations in them. To achieve a therapeutic effect, it is enough to use the drug once a day.
After applying the cream to the skin, less than 6% of naftifine enters the systemic circulation. In the body, only a part of the absorbed active substance is metabolized. The drug is excreted through the kidneys and intestines. The half-life is 2–3 days.
Indications for use
- fungal infections of the skin and skin folds of the surface of the hands, feet, body;
- shingles (tinea inguinalis);
- dermatomycosis, including with concomitant itching;
- interdigital mycoses (tinea pedum, tinea manum);
- candidiasis of the skin;
- multicolored (pityriasis) versicolor;
- onychomycosis (fungal infections of the nail plates).
Contraindications
Absolute:
- application to the wound surface;
- period of pregnancy;
- breast-feeding;
- hypersensitivity to the components of the drug.
Naftifine should be used with caution against fungus in childhood.
Naftifin, instructions for use: method and dosage
The cream and solution are intended for external use.
When treating skin fungal pathologies, a sufficient amount of the drug is applied to the previously thoroughly cleaned and dried area of the lesion and the adjacent area (about 1 cm of a healthy skin area).
With onychomycosis, the drug is applied to the affected nail. Before the first use, keratinized tissue should be removed from the nail plate as much as possible using a nail file and scissors.
It is necessary to use the drug on the recommendation of a doctor, after conducting appropriate laboratory tests.
Recommended dosage regimen:
- skin lesions: the frequency of procedures - 1 time per day. Duration of treatment: dermatomycosis - from 14 to 56 days, candidiasis - 28 days;
- onychomycosis: frequency of procedures - 2 times a day. Treatment can last up to 180 days.
In order to prevent the development of a relapse of the disease, the use of the cream or solution of the drug should be continued after the complete disappearance of clinical symptoms for at least 14 days.
If there is no clinical improvement during treatment or new symptoms appear, you should consult a doctor.
Side effects
When using Naftifin, such transient local reactions as burning, dryness or hyperemia (redness) of the skin may occur, which do not require discontinuation of treatment.
In addition, when treated with a solution, patients may experience skin irritation.
Overdose
Overdose symptoms have not been established. If you follow the instructions for using the cream or drug solution, an overdose is unlikely.
Treatment: in case of accidental ingestion of naftifine inside, immediate gastric lavage and the appointment of symptomatic therapy are indicated.
special instructions
In case of aggravation of the side effects typical for the drug or the development of any other undesirable phenomena, you should immediately consult a doctor.
Do not allow Naftifin to get into the eyes.
You should not skip daily treatments or interrupt the course of treatment prematurely. Strict adherence to the course of treatment is a guarantee of achieving a therapeutic effect.
The solution is effective for the treatment of mycoses located in the area of the skin with hyperkeratosis and hair growth zones.
Influence on the ability to drive vehicles and complex mechanisms
The use of Naftifine from the fungus does not affect the ability of patients to drive vehicles and complex mechanisms that require increased attention or high speed of psychomotor reactions.
Application during pregnancy and lactation
Due to the lack of information on safety and efficacy, the use of Naftifine is contraindicated during gestation and breastfeeding.
Pediatric use
It is recommended to use the drug with caution to treat children.
Drug interactions
Studies on the interaction of Naftifine with other drugs have not been conducted.
Analogs
Naftifine analogs are Mizol Evalar, Mikoderil, Naftoderil, Exoderil, Exostat, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperature: solution - up to 25 ° C, cream - up to 30 ° C.
Shelf life: solution - 3 years, cream - 5 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Naftifine
Reviews about Naftifine are rare. Patients using the cream to treat a fungal infection on the toenails indicate that the drug is effective.
The price of Naftifin in pharmacies
The approximate price for Naftifin may be:
- solution: 398-429 rubles. (in a bottle of 10 ml) or 668 rubles. (in a bottle 20 ml);
- cream: RUB 312–398 (in the package 1 tube of 15 g) or 548 rubles. (in the package 1 tube of 30 g).
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
