Metindol retard
Metindol retard: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Metindol retard
ATX code: M01AB01
Active ingredient: indomethacin (indometacin)
Producer: ICN Polfa Rzeszow (Poland)
Description and photo updated: 2019-27-08
Prices in pharmacies: from 142 rubles.
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Metindol retard is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects.
Release form and composition
Dosage form - prolonged-release tablets: white (yellowish tint is possible), with a flat surface and a cut edge (25 pcs. In blisters, in a cardboard box 1 or 2 blisters and instructions for using Metindol retard).
Active ingredient: indomethacin, its content in 1 tablet is 75 mg.
Excipients: potato starch, magnesium stearate, methacrylic acid copolymer, microcrystalline cellulose.
Pharmacological properties
Pharmacodynamics
Indomethacin - the active substance of Metindol retard, has anti-inflammatory, analgesic and antipyretic effects. The mechanism of its action is associated with inhibition of the activity of the enzyme cyclooxygenase and a decrease in the synthesis of prostaglandins, which cause the development of pain syndrome, an increase in temperature and an increase in tissue permeability in the focus of inflammation.
In patients with articular syndrome, Metindol retard helps to increase the range of motion, reduce inflammation, and also relieves pain during movement and at rest, reduces the severity of morning stiffness and swelling of the joints.
Pharmacokinetics
Indomethacin is rapidly absorbed. The biological availability of the substance is 90% (within 12 hours). With max (maximum concentration of the substance) is 0.69 μg / ml, the time to reach it is 2 hours.
Binds to plasma proteins at a level of 90%. Metabolism occurs primarily in the liver.
T 1/2 (half-life) is in the range from 4 to 9 hours (the value of the indicator may vary depending on the severity of systemic metabolism, reabsorption and enterohepatic circulation). 70% of the dose is excreted by the kidneys (with 30% unchanged), through the gastrointestinal tract - 30%. Indomethacin passes into breast milk; when a mother uses 200 mg of a substance per day, 0.5–2 mg is determined in milk. It is not removed by dialysis.
Indications for use
Metindol retard is a drug for the symptomatic treatment of diseases accompanied by inflammation and pain syndrome:
- Bechterew's disease (ankylosing spondylitis) and other inflammatory-rheumatic diseases of the spine;
- Pain syndrome in diseases of the spine;
- Rheumatic diseases of soft tissues;
- Rheumatoid arthritis;
- Gouty arthritis;
- Inflammation and pain syndrome after trauma or surgery (including dental and gynecological).
Contraindications
Absolute:
- Exacerbation of inflammatory bowel diseases (ulcerative colitis, Crohn's disease);
- Active gastrointestinal bleeding, erosive and ulcerative lesions of the gastric mucosa and / or duodenum 12;
- Confirmed hyperkalemia;
- Blood clotting disorders (including hemophilia, bleeding tendency, prolonged bleeding time);
- Progressive kidney disease, severe renal failure (creatinine clearance less than 30 ml / minute);
- Active liver disease, severe liver failure;
- A history of bronchospasm, rhinitis or urticaria caused by taking acetylsalicylic acid or other NSAIDs (complete or incomplete intolerance to acetylsalicylic acid - nasal mucosa polyps, urticaria, rhinosinusitis, asthma);
- Congenital heart defects (pulmonary atresia, severe coarctation of the aorta, severe tetralogy of Fallot);
- The period after coronary artery bypass grafting;
- Pregnancy and lactation period;
- Age under 18;
- Hypersensitivity to the components of Metindol retard.
Relative:
- Concomitant therapy with the following drugs: antiplatelet agents, oral glucocorticosteroids, anticoagulants, selective serotonin reuptake inhibitors;
- Long-term use of NSAIDs;
- Frequent alcohol consumption;
- Smoking;
- Elderly age;
- Mental disorders;
- Postoperative period after surgery;
- Helicobacter pylori infection;
- Anamnestic data on the development of ulcerative lesions of the gastrointestinal tract;
- Creatinine clearance less than 60 ml / minute;
- Liver cirrhosis with portal hypertension;
- Severe somatic diseases;
- Arterial hypertension;
- Parkinsonism;
- Dyslipidemia / hyperlipidemia;
- Diabetes;
- Cerebrovascular disease;
- Epilepsy;
- Cardiac ischemia;
- Congestive heart failure;
- Hematopoietic disorders (leukopenia and anemia);
- Peripheral artery disease;
- Thrombocytopenia;
- Depression.
Metindol retard, instructions for use: method and dosage
Metindol retard should be taken orally, swallowing tablets whole, during or immediately after a meal, with a sufficient amount of liquid (water or milk).
Adult patients are prescribed 1-2 tablets per day.
The highest permissible daily dose of indomethacin is 150 mg (2 tablets).
Side effects
- Digestive system: NSAIDs gastropathy, heartburn, diarrhea, abdominal pain, loss of appetite, nausea, vomiting, ulceration of the gastrointestinal tract mucosa (including with perforation and / or bleeding), liver dysfunction (hyperbilirubinemia, increased liver activity) transaminases);
- Nervous system: irritability, excessive fatigue, agitation, drowsiness, insomnia, depression, vertigo, headache, peripheral neuropathy;
- Urinary system: hematuria, proteinuria, interstitial nephritis, papillary necrosis, nephrotic syndrome, renal dysfunction;
- Cardiovascular system: tachyarrhythmia, increased blood pressure, edema syndrome, development or aggravation of existing chronic heart failure;
- Hematopoietic organs and hemostasis system: anemia (including hemolytic and aplastic), agranulocytosis, eosinophilia, thrombocytopenia, thrombocytopenic purpura, leukopenia, bleeding (gingival, gastrointestinal, hemorrhoidal, uterine);
- Sense organs: tinnitus, hearing loss, double vision, taste disturbances, conjunctivitis, clouding of the cornea of the eyes, blurred vision;
- Allergic reactions: itching of the skin, skin rash, urticaria, bronchospasm, angioedema; in isolated cases - anaphylactic shock, photosensitization, erythema nodosum, toxic epidermal necrolysis;
- Laboratory indicators: hyperglycemia, thrombocytopenia, glucosuria, leukopenia, hyperkalemia, agranulocytosis;
- Others: increased sweating, autoimmune hemolytic and aplastic anemia, aseptic meningitis (more often in patients with autoimmune diseases).
Overdose
The main symptoms (characteristic of indomethacin): vomiting, nausea, dizziness, severe headache, disorientation, memory impairment. In more severe cases, the development of paresthesias, numbness of the limbs and convulsions is noted.
Therapy: rapid elimination of indomethacin from the body, symptomatic treatment.
Through hemodialysis, the substance is not excreted from the body.
special instructions
To reduce the risk of developing adverse reactions, the minimum effective dose of Metindol retard should be used for as short a period as possible.
To prevent or reduce dyspeptic symptoms, you can take antacids.
During treatment, it is necessary to monitor the peripheral blood picture, the functional state of the kidneys and liver.
If it is necessary to conduct a study to determine 17-ketosteroids, Metindol retard should be canceled 48 hours before the appointed time.
Influence on the ability to drive vehicles and complex mechanisms
During the period of Metindol retard use, care should be taken when driving and performing tasks that require a high speed of reactions and increased concentration of attention.
Application during pregnancy and lactation
Metindol retard is not prescribed during pregnancy / lactation.
Pediatric use
For patients under 18 years of age, the drug is not prescribed.
With impaired renal function
- severe renal failure (in patients with creatinine clearance less than 30 ml / min), progressive kidney disease: therapy is contraindicated;
- renal failure (in patients with creatinine clearance of 30 to 60 ml / min): Metindol retard is prescribed with caution.
For violations of liver function
- severe liver failure, active liver disease: therapy is contraindicated;
- liver cirrhosis with portal hypertension: Metindol retard is prescribed with caution.
Use in the elderly
Elderly patients Metindol retard is prescribed under medical supervision.
Drug interactions
If necessary, the simultaneous use of the following drugs, it is important to consider that indomethacin:
- Increases the plasma concentration of methotrexate, lithium and digoxin preparations, as a result of which their toxicity may increase;
- Enhances the hypoglycemic effect of insulin and oral hypoglycemic drugs;
- Reduces the effectiveness of uricosuric and antihypertensive drugs (including beta-blockers);
- Strengthens the effect of indirect antiplatelet agents, anticoagulants, thrombolytics (streptokinase, alteplase, urokinase), which results in the risk of bleeding;
- Increases the side effects of acetylsalicylic acid, other NSAIDs, glucocorticosteroids, estrogens;
- Reduces the effect of diuretics; when used in combination with potassium-sparing diuretics - increases the risk of hyperkalemia;
- Increases the toxicity of zidovudine;
- Increases the risk of developing toxic effects of aminoglycosides in newborns (since it reduces their renal clearance and increases the concentration in the blood).
When using Metindol retard in combination with the following drugs, the risk of side effects increases:
- Glucocorticosteroids, colchicine, corticotropin, serotonin reuptake inhibitors, ethanol: the risk of gastrointestinal bleeding increases;
- Cyclosporin, paracetamol, gold preparations: the nephrotoxicity of indomethacin increases;
- Antacids and cholestyramine: absorption of indomethacin decreases;
- Myelotoxic drugs: manifestations of indomethacin hematotoxicity increase;
- Valproic acid, cefoperazone, plikamycin, cefamandol, cefotetan: the incidence of hypoprothrombinemia increases, the risk of bleeding increases.
Analogs
Metindol retard analogs are: Indomethacin, Indomethacin Sopharma, Indomethacin-Biosynthesis, Indovis EC.
Terms and conditions of storage
Store in a dark, dry place out of reach of children. Observe the temperature regime 15-25 ° С.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Metindol retard
Most reviews about Metindol retard indicate its high efficiency. There are practically no reports of the development of adverse reactions.
Price for Metindol retard in pharmacies
The approximate price of Metindol retard (25 or 50 pieces) is 151-166 or 227-251 rubles.
Metindol retard: prices in online pharmacies
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Drug name Price Pharmacy |
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Metindol retard 75 mg extended-release tablets 25 pcs. 142 RUB Buy |
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Metindol Retard tablets 75mg 25 pcs. 207 r Buy |
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Metindol retard 75 mg extended-release tablets 50 pcs. 216 r Buy |
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Metindol Retard tablets 75mg 50 pcs. 309 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
