Ibufen

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Instructions for use:

1. Release form and composition
2. Indications for use
3. Contraindications
4. Method of application and dosage
5. Side effects
6. Special instructions
7. Drug interactions
8. Analogs
9. Terms and conditions of storage
10. Terms of dispensing from pharmacies

Ibufen is a non-steroidal anti-inflammatory drug (NSAID).

Release form and composition

Dosage form - suspension for oral administration: orange, with the smell of orange, separation into a liquid layer and a precipitate is possible (after shaking, they are mixed and form a homogeneous suspension) (100 g each in dark glass bottles, in a cardboard box 1 bottle complete with a measured spoon; 100 g each in plastic bottles, in a cardboard box 1 bottle complete with a dosing syringe).

Active ingredient: ibuprofen, in 5 ml of suspension - 100 mg.

Additional substances: macrogol glyceryl hydroxystearate, methyl parahydroxybenzoate, sodium phosphate dihydrate, glycerol, sucrose, sodium carmellose, sodium saccharinate, propyl parahydroxybenzoate, magnesium aluminum silicate (veegum), crospovidone, propylene glycol, citric acid orange dye monohydrate purified water.

Indications for use

Ibufen is used to treat children.

As an antipyretic agent:

Colds;
Acute respiratory viral infections, including influenza;
Angina (tonsillitis);
Children's infectious diseases;
Post-vaccination reactions.

As an anesthetic for pain syndrome of various origins of weak and moderate intensity:

Painful teething, toothache;
Headache, migraine;
Earache with inflammation of the middle ear;
Pain in muscles and joints due to injuries of the musculoskeletal system;
Neuralgia.

The drug is intended for symptomatic therapy, it reduces pain and inflammation during its use, does not affect the progression of the disease.

Contraindications

Absolute:

Complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses with intolerance to acetylsalicylic acid or other NSAIDs (including a history);
Active liver disease, severe liver failure;
Progressive kidney disease, severe renal failure (creatinine clearance less than 30 ml / minute);
Inflammatory bowel disease;
Erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer of the stomach and 12 duodenal ulcer in the acute phase, peptic ulcer, ulcerative colitis, Crohn's disease);
Glucose-galactose malabsorption, fructose intolerance;
Sucrase / isomaltase deficiency;
Confirmed hyperkalemia;
Blood clotting disorders (including a tendency to bleed, prolonged bleeding time, hemophilia, hemorrhagic diathesis);
Children up to age 3 months;
Hypersensitivity to the components of the drug, acetylsalicylic acid or other NSAIDs.

Relative (for the following diseases / conditions, treatment with Ibufen should be carried out with extreme caution due to the risk of complications):

Diabetes;
History of gastric ulcer and 12-duodenal ulcer;
Presence of Helicobacter pylori infection;
Enteritis;
Gastritis;
Colitis;
Hepatic and / or renal failure;
Liver cirrhosis with portal hypertension;
Nephrotic syndrome;
Severe somatic diseases;
Diseases of the blood of unknown etiology (leukopenia and anemia);
Hyperbilirubinemia;
Arterial hypertension, chronic heart failure;
Children age 3-6 months;
Long-term use of NSAIDs;
Simultaneous use of oral glucocorticosteroids (including prednisolone), antiplatelet agents (including clopidogrel), anticoagulants (including warfarin).

Method of administration and dosage

Ibufen should be taken orally after meals. Shake the bottle immediately before taking. A measuring spoon or syringe is included for accurate dosing.

A single dose is 5-10 mg per kilogram of body weight. Frequency of admission - up to 4 times a day at intervals of 6-8 hours. The maximum allowable daily dose is 20-30 mg / kg.

Recommended dosage regimens depending on the age and weight of the child:

6-12 months (body weight 7.7-9 kg): 2.5 ml 3 times a day;
1-3 years (10-15 kg): 2.5 ml 3-4 times a day;
4-6 years (16-20 kg): 5 ml 3 times a day;
7-9 years (21-29 kg): 5 ml 4 times a day;
10-12 years old (30-41 kg): 10 ml 3 times a day.

Children between the ages of 3 and 6 months should only be given Ibufen as directed by their healthcare professional. The daily dose for them should not exceed 5 ml of suspension. For post-vaccination reactions, 2.5 ml are prescribed, after 6 hours - another 2.5 ml.

Duration of use of the drug, depending on the indications: reduction of increased body temperature - up to 3 days, relief of pain - no more than 5 days.

Using Ibufen with a measuring syringe:

Open the bottle: press the cap, pushing it down and turn it counterclockwise;
Insert the syringe into the opening of the neck of the bottle;
Shake the bottle vigorously;
Turn the bottle upside down and, carefully moving the syringe plunger down, pour the contents until the required mark on the scale is reached;
Turn the bottle over to its original position and remove the dispenser with gently rotating movements;
Place the syringe in the child's oral cavity and, slowly pressing the plunger, inject the suspension;
Close the bottle with a cap, rinse the dispenser with clean water and dry.

Side effects

From the respiratory system: shortness of breath, bronchospasm;
From the side of hematopoiesis: agranulocytosis, thrombocytopenic purpura, leukopenia, thrombocytopenia, anemia (including aplastic and hemolytic);
From the digestive system: aphthous stomatitis, dryness of the oral mucosa, ulceration of the mucous membrane of the gums and gastrointestinal tract (sometimes complicated by perforation and bleeding), NSAID gastropathy (decreased appetite, flatulence, diarrhea, abdominal pain, pain and discomfort in epigastric region, heartburn, nausea, vomiting), constipation, pancreatitis, hepatitis;
From the side of the cardiovascular system: increased blood pressure, tachycardia, development or worsening of heart failure;
From the nervous system: drowsiness, sleep disturbances, psychomotor agitation, depression, irritability, anxiety, confusion, dizziness, hallucinations, headache; rarely - aseptic meningitis (more often in patients with autoimmune diseases);
From the urinary system: allergic nephritis, cystitis, polyuria, nephrotic syndrome (edema), acute renal failure;
From the senses: dryness and irritation of the eyes, color vision disturbance, amblyopia, scotoma, blurred vision or diplopia, edema of the conjunctiva and eyelids (allergic genesis), reversible toxic optic neuritis, ringing or tinnitus, hearing loss;
Allergic reactions: skin rash (erythematous or urticaria), pruritus, fever, bronchospasm, anaphylactoid reactions, angioedema, anaphylactic shock, allergic rhinitis, eosinophilia, toxic epidermal necrolysis, exudative erythema multiforme;
Others: increased sweating.

special instructions

With prolonged use of Ibufen, it is necessary to monitor the peripheral blood picture, the functional state of the kidneys and liver.

In bronchial asthma or other diseases that may be accompanied by bronchospasm, ibuprofen can cause bronchospasm. For this reason, in these patients, the drug should only be used with great care. If you have difficulty breathing, you should immediately consult a doctor.

To prevent the development of NSAID gastropathy, Ibufen is recommended to be combined with prostaglandin E preparations (for example, misoprostol). When symptoms of the disease appear, careful monitoring of the patient's condition is necessary, including an analysis of feces for occult blood, a blood test with the determination of hemoglobin and hematocrit, and esophagogastroduodenoscopy.

To reduce the risk of developing side effects from the gastrointestinal tract, Ibufen should be taken in the lowest effective dose for the shortest possible period.

Patients referred for a 17-ketosteroid study should stop ibuprofen 48 hours in advance.

During treatment, it is recommended to avoid taking drugs containing ethanol, as well as performing tasks that require increased attention and speed of reactions.

Patients with diabetes mellitus should take into account that 1 ml of suspension contains about 0.34 g of sucrose or about 0.03 XE. Thus, the minimum single dose of Ibufen (2.5 ml) contains 0.85 g of sucrose (0.075 XE), the maximum single dose (15 ml) - 5.13 g of sucrose (0.45 XE).

Drug interactions

Other NSAIDs (including acetylsalicylic acid): the anti-inflammatory effect of ibuprofen decreases, side effects increase (this combination is contraindicated);
Diuretics: their effect is weakened, the risk of developing renal failure increases (this combination is recommended to be avoided if possible);
Vasodilators (including angiotensin-converting enzyme inhibitors): their hypotensive activity decreases;
Oral hypoglycemic agents (especially sulfonylurea derivatives) and insulin: their effect is enhanced;
Microsomal oxidation inducers (phenylbutazone, rifampicin, phenytoin, tricyclic antidepressants, barbiturates, ethanol): the risk of severe hepatotoxic reactions increases;
Cholestyramine, antacids: absorption of ibuprofen decreases;
Valproic acid, cefoperazone, plikamycin, cefamandol, cefotetan: the incidence of hypoprothrombinemia increases;
Gold preparations, cyclosporins: increased nephrotoxicity of ibuprofen;
Means with myelotoxic effect: manifestations of hematotoxicity of ibuprofen increase;
Cyclosporine: its plasma concentration increases and the likelihood of developing hepatotoxic effects;
Drugs that block tubular secretion: excretion decreases and plasma concentration of ibuprofen increases;
Antiplatelet agents, indirect anticoagulants, fibrinolytics: their effect increases, the risk of hemorrhagic complications increases;
Caffeine: increases the analgesic effect of ibuprofen;
Digoxin, methotrexate, lithium preparations: their concentration in the blood increases.

Analogs

Ibufen's analogues are: Ibuprofen, Ibuprone, Ibusan, Nurofen.

Terms and conditions of storage

Store at temperatures up to 25 ºС in a place protected from light, out of reach of children.

Shelf life - 3 years, after the first opening of the bottle - 6 months.

Terms of dispensing from pharmacies

Available without a prescription.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!