Diabefarm - Instructions For Use, Indications, Doses, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Diabefarm

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Analogs
9. 9. Terms and conditions of storage
10. 10. Terms of dispensing from pharmacies

Prices in online pharmacies:

from 91 rub.

Buy

Diabetharm is an oral hypoglycemic drug from the 2nd generation sulfonylurea group.

Release form and composition

Dosage form - tablets: flat-cylindrical, with a cross-shaped line and a chamfer, white or white-yellowish (10 pcs. In blister strip packs, in a cardboard box 3 or 6 packs; 20 pcs. In a blister strip packaging, in a cardboard box 3 packs; 60 or 240 pcs. in polyethylene bottles, in a cardboard box 1 bottle).

Composition for 1 tablet:

• active substance: gliclazide - 80 mg;
• auxiliary ingredients: povidone, milk sugar (lactose monohydrate), magnesium stearate.

Indications for use

Diabetharm is recommended for use in adult patients for the treatment of type 2 diabetes mellitus in combination with moderate physical activity and diet therapy, if they are ineffective without drug support.

Contraindications

Absolute:

• type 1 diabetes mellitus;
• diabetic ketoacidosis, diabetic precoma / coma;
• hyperosmolar coma;
• severe renal / liver dysfunction;
• extensive injuries and burns, major surgical interventions, other conditions requiring insulin therapy;
• intestinal obstruction, gastric paresis;
• diseases / conditions accompanied by the development of hypoglycemia, impaired absorption of food (including infectious diseases);
• leukopenia;
• pregnancy (in case of pregnancy during therapy with gliclazide, it should be stopped immediately);
• breastfeeding (lactation);
• children and adolescents up to 18 years old;
• hypersensitivity to any component of the drug.

Relative (it is necessary to more carefully select the dose and carry out treatment under the supervision of a doctor): febrile syndrome, thyroid disease with dysfunction, alcoholism.

Method of administration and dosage

The tablets are taken orally 0.5-1 hour before meals, twice a day, in the morning and evening.

The dose for each patient is set individually and depends on his age, clinical manifestations of the disease, as well as the level of fasting blood glucose and 2 hours after eating.

The recommended daily doses of gliclazide should be adhered to:

• initial - 80 mg;
• medium - 160 mg;
• maximum - 320 mg.

Side effects

With an inadequate diet and non-compliance with the dosage regimen, hypoglycemia may develop, the symptoms of which are: fatigue, headache, dizziness, hunger, hyperhidrosis, severe weakness, anxiety, aggressiveness, loss of self-control, delayed reaction, decreased concentration, depression, irritability, visual impairment, tremor, aphasia, bradycardia, sensory disorders, convulsions, hypersomnia, loss of consciousness, shallow breathing, delirium.

Other side effects from systems and organs:

• hematopoietic organs: anemia, leukopenia, thrombocytopenia;
• digestive system: dyspepsia (feeling of heaviness in the epigastrium, nausea, diarrhea), anorexia (the severity of the reaction decreases when taking tablets with meals), liver failure (increased activity of liver enzymes, cholestatic jaundice);
• hypersensitivity reactions: urticaria, pruritus, maculopapular rash.

An overdose symptom is hypoglycemia, up to the development of hypoglycemic coma. For therapy, a patient who is awake should ingest easily digestible carbohydrates (glucose); in case of a disorder of consciousness, it is required to inject a 40% solution of glucose (dextrose) intravenously and intramuscularly 1-2 mg of glucagon. After recovery of consciousness, the patient should be given food rich in easily digestible carbohydrates (to avoid the recurrence of hypoglycemia). Dexamethasone and mannitol are used for cerebral edema.

special instructions

Diabepharm therapy is carried out simultaneously with a low-calorie, low-carbohydrate diet. At the same time, it is necessary to regularly monitor the content of glucose in the blood on an empty stomach and after meals.

In the course of surgery or diabetes decompensation, the likelihood of using insulin preparations should be considered.

Patients should be informed about the increased risk of hypoglycemia during fasting and taking non-steroidal anti-inflammatory drugs (NSAIDs), ethanol during treatment. The consequence of the use of ethanol can also be the development of a disulfiram-like reaction, manifested by abdominal pain, nausea, vomiting, and headache.

Physical or emotional stress, a change in diet may require a dose adjustment of Diabefarm.

Elderly patients, people who do not receive a balanced diet, patients with pituitary-adrenal insufficiency and debilitated patients are especially susceptible to the action of hypoglycemic drugs.

At the beginning of therapy, when selecting a dose, it is not recommended for patients with a tendency to develop hypoglycemia to engage in activities requiring the speed of psychomotor reactions and concentration of attention.

Drug interactions

• angiotensin-converting enzyme inhibitors (enalapril, captopril), antifungal drugs (fluconazole, miconazole), H ₂ -histamine receptor blockers (cimetidine), NSAIDs (phenylbutazone, diclofenac, indomethacin), anti-tuberrate amylophilic drugs, etibonafibrate coumarin series, salicylates, anabolic steroids, cyclophosphamide, β-blockers, chloramphenicol, MAO (monoamine oxidase) inhibitors, fenfluramine, prolonged-release sulfonamides, pentoxifylline, fluoxetine, guanethidine, canalipyraline, blockers, blockers ethanol and ethanol-containing substances / drugs, other hypoglycemic drugs (biguanides, acarbose, insulin) - enhance the hypoglycemic effect of gliclazide;
• sympathomimetics (clonidine, ritodrin, epinephrine, terbutaline, salbutamol), corticosteroids (glucocorticosteroids), barbiturates, thiazide diuretics, slow calcium channel blockers, phenytoin, carbonic anhydrase inhibitors (acetazolamide), chlorthazemidone, asparaenterazole, furosemidone isoniazid, glucagon, morphine, thyroid hormones, rifampicin, lithium salts, high doses of nicotinic acid, chlorpromazine, estrogens and oral contraceptives containing them - weaken the hypoglycemic effect of gliclazide;
• ethanol - a disulfiram-like reaction is possible;
• cardiac glycosides - Diabepharm increases the risk of ventricular premature beats;
• clonidine, reserpine, β-blockers, guanethidine - can mask the clinical manifestations of hypoglycemia;
• drugs that inhibit bone marrow hematopoiesis - increase the risk of myelosuppression.

Analogs

Analogs of Diabefarm are: Diabeton MB, Gliclada, Glidiab, Gliclazid Canon, Gliclazide-AKOS, Gliclazide MV, Diabeton, Diabetalong, Diabinax, etc.

Terms and conditions of storage

Store in a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Diabefarm: prices in online pharmacies

Drug name Price Pharmacy

Diabefarm 80 mg tablets 60 pcs. 91 rbl. Buy

Diabefarm MV 30 mg modified release tablets 60 pcs. RUB 95 Buy

Diabefarm MV tablets with modif. release 30mg 60 pcs. RUB 99 Buy

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!