Daraprim
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Daraprim is an antimalarial drug.
Release form and composition
Daraprim is available in the form of tablets (25 mg, 20 in a package).
The active substance is pyrimethamine, its content in 1 tablet is 25 mg.
Indications for use
- prevention and treatment of malaria;
- toxoplasmosis.
Contraindications
The use of the drug is contraindicated in patients with established hypersensitivity to pyrimethamine.
Care should be taken when prescribing Daraprim to patients with hepatic or renal insufficiency, folic acid deficiency (congenital or due to malnutrition).
Method of administration and dosage
The tablets are taken orally.
Recommended dosage:
- prevention of malaria: adults - 25 mg, children 5-10 years old - 12.5 mg once a week; after returning to a safe area where there is no risk of contracting malaria, the drug should be continued for 4 weeks;
- malaria treatment (in combination with sulfadoxine or sulfalene): once; adults - 50–75 mg + 1–1.5 g of sulfanilamide, children 9–14 years old - 50 mg + 1 g of sulfanilamide, children 4–8 years old - 25 mg + 0.5 g of sulfanilamide;
- toxoplasmosis: initial dose for patients from 6 years old (in combination with sulfadiazine at a dose of 150 mg per 1 kg of patient weight, but not higher than 4000 mg) - 50 mg, children 2-6 years old (the dose is determined taking into account the weight of the child) - 2 mg per 1 kg (but not more than 50 mg), children under 2 years old - 1 mg per 1 kg of the child's weight per day. Then the dose is reduced: for patients over 6 years old - up to 25 mg per day, for children 2-6 years old - up to 1 mg per 1 kg of the child's weight (but more than 25 mg) per day.
Side effects
- from the digestive system: cramping abdominal pain, dry mouth or throat, diarrhea, nausea, vomiting;
- from the nervous system: weakness, headache, dizziness, depression;
- dermatological reactions: skin pigmentation disorders, dermatitis, rash;
- from the circulatory and lymphatic systems: anemia, leukopenia, thrombocytopenia;
- on the part of the cardiovascular system: possibly - a violation of the heart rhythm (at a dose of 75 mg);
- from the urinary system: possibly - hematuria (at a dose of 75 mg);
- others: fever; at a dose of more than 75 mg - insomnia, ulceration in the mouth, circulatory collapse; rarely - phenylalaninemia in newborns with congenital toxoplasmosis.
special instructions
With toxoplasmosis, the simultaneous administration of calcium folinate or folic acid is necessary, this will reduce the risk of bone marrow suppression.
During the entire period of treatment and two weeks after discontinuation of the drug, it is recommended to determine the blood formula regularly, once a week.
The use of the drug as a prophylaxis during pregnancy is possible, but only when combined with folic acid preparations.
With toxoplasmosis of pregnant women, it is allowed to prescribe Daraprim in combination with calcium folinate in case of an increase in antibody titer or if a woman is threatened with loss of vision.
When treating with the drug during breastfeeding, you cannot simultaneously prescribe antifolic drugs to the baby.
Drug interactions
With the simultaneous use of Daraprim:
- warfarin, quinidine - increase their effectiveness and toxic effects;
- lorazepam - increases the risk of liver toxicity;
- cytostatics (especially methotrexate) - increase myelosuppression;
- methotrexate and pyrimethamine - increase the risk of seizures in children with leukemia and central nervous system damage;
- cytosine-arabinoside, daunorubicin, pyrimethamine - can cause bone marrow aplasia in patients with acute myeloid leukemia.
Analogs
There is no information on analogues.
Terms and conditions of storage
Keep out of the reach of children.
See the expiration date on the packaging.
Terms of dispensing from pharmacies
Dispensed by prescription.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
