Godasal
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Godasal is a combined drug with antiaggregatory, anti-inflammatory, antipyretic, analgesic action.
Release form and composition
Godasal is produced in the form of tablets: round biconvex, from almost white or white to light yellow, with a dividing line on one side, with a weak lemon scent (10 pcs. In a blister, in a cardboard box of 10, 5 or 2 blisters).
1 tablet contains:
- active substances: acetylsalicylic acid - 100 mg, glycine - 50 mg;
- auxiliary components: cellulose, corn starch, sodium saccharinate, lemon flavor.
Indications for use
The use of Godasala is indicated in the treatment of unstable angina pectoris and for the prevention of the following diseases:
- stroke;
- acute myocardial infarction in patients with risk factors (including arterial hypertension, diabetes mellitus, hyperlipidemia, obesity, smoking, in old age), repeated myocardial infarction;
- transient violation of cerebral circulation;
- thromboembolism after invasive interventions and vascular surgery (including coronary artery bypass grafting, stenting and angioplasty of coronary arteries, endarterectomy of the carotid arteries);
- thromboembolism of the pulmonary artery and its branches, deep vein thrombosis (including conditions of prolonged immobilization after major surgical intervention).
Contraindications
- gastrointestinal bleeding;
- period of exacerbation of erosive and ulcerative lesions of the gastrointestinal tract (GIT);
- hemorrhagic diathesis;
- chronic heart failure III – IV functional class according to NYHA classification (New York Association of Cardiology);
- bronchial asthma caused by the intake of non-steroidal anti-inflammatory drugs (NSAIDs), including salicylates;
- severe renal failure [creatinine clearance (CC) less than 30 ml / min];
- severe hepatic impairment (class B and higher on the Child-Pugh scale);
- simultaneous use of methotrexate at a dose of 15 mg or more per week;
- I and III trimesters of pregnancy;
- breast-feeding;
- age up to 18 years;
- hypersensitivity to NSAIDs and drug components.
Caution should be exercised in patients with gastric ulcer and duodenal ulcer and / or gastrointestinal bleeding in history, renal failure (CC above 30 ml / min), drug allergies (including anti-inflammatory and antirheumatic drugs, analgesics), liver failure below class B by Child-Pugh scale, bronchial asthma, hay fever, chronic diseases of the respiratory system, with nasal polyposis, gout, hyperuricemia, planning any surgical intervention (including tooth extraction), alcohol consumption, during the second trimester of pregnancy.
In addition, Godasal is taken with caution with concomitant therapy with the following drugs: methotrexate at a dose of up to 15 mg per week, thrombolytic or antiplatelet agents, digoxin, anticoagulants, high doses of salicylic acid derivatives and NSAIDs, valproic acid, oral hypoglycemic agents (sulfonylurea derivatives), insulin, ibuprofen, selective serotonin reuptake inhibitors, ethanol-containing agents.
Method of administration and dosage
The tablets are taken orally, preferably before meals, with a significant amount of liquid.
The drug should be used only as directed by a doctor.
Recommended dosage:
- unstable angina: 1 pc. in a day;
- primary prevention of acute myocardial infarction in patients with risk factors: 1 pc. in a day;
- prevention of re-myocardial infarction, stroke, transient cerebrovascular accident, thromboembolism: 1 pc. in a day;
- prevention of thromboembolism of the pulmonary artery and its branches, deep vein thrombosis: 1–2 pcs. in a day.
Godasal is intended for long-term use; the doctor prescribes the duration of therapy individually.
Side effects
- on the part of the hematopoietic system: most often - intra- and postoperative bleeding, hematomas, nosebleeds, bleeding gums, bleeding from the urinary tract; possibly - gastrointestinal bleeding, cerebral hemorrhage [more often with arterial hypertension, which has not reached the target level of blood pressure (BP) and / or concomitant anticoagulant therapy], including with a fatal outcome;
- from the central nervous system: dizziness, tinnitus, hearing loss;
- from the digestive system: most often - heartburn, nausea, vomiting, pain in the abdomen; rarely - gastrointestinal bleeding, ulceration of the mucous membrane of the stomach and duodenum (including perforation), transient liver dysfunction, increased activity of liver enzymes;
- allergic reactions: rhinitis, swelling of the nasal mucosa, skin rash, itching, Quincke's edema, urticaria, cardiorespiratory distress syndrome, anaphylactic shock.
special instructions
The presence of acetylsalicylic acid can contribute to the development of bronchospasm, attacks of bronchial asthma and other hypersensitivity reactions. Risk factors include patients with a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory system pathologies, allergic reactions (including pruritus, skin reactions, urticaria) to other drugs.
Since the inhibitory effect of the drug on platelet aggregation after taking the pill persists for several days, during a planned operation, the use of Godasal should be canceled in the preoperative period. This will reduce the risk of bleeding during surgery and in the postoperative period.
Bleeding, especially latent, can cause the development of an acute or chronic form of post-hemorrhagic or iron deficiency anemia, the main signs of which are pallor of the skin, asthenia, hypoperfusion.
Patients with reduced uric acid excretion are prone to developing gout while taking the drug.
With concomitant therapy with methotrexate, the incidence of adverse events from the hematopoietic organs increases.
High doses of the drug have a hypoglycemic effect, this must be taken into account when prescribing it to patients with diabetes mellitus who are on therapy with oral hypoglycemic agents (sulfonylurea derivatives) and insulin.
With an increased risk of cardiovascular disease, it is recommended to avoid the combination with ibuprofen, as it reduces the cardioprotective effect of Godasal.
Treatment should be carried out in strict accordance with the recommended dosage regimen, since overdose is associated with the risk of gastrointestinal bleeding, especially in elderly patients.
The simultaneous use of alcoholic beverages increases the risk of damage to the gastrointestinal mucosa, lengthening the bleeding time.
The tablets do not affect the patient's ability to drive vehicles and mechanisms.
Drug interactions
While taking Godasala:
- methotrexate significantly enhances its effect against the background of a decrease in renal clearance and displacement from the connection with blood plasma proteins;
- antiplatelet (ticlopidine) and thrombolytic agents, anticoagulants cause synergy of the main effects of the drugs taken, which increases the risk of bleeding;
- drugs with thrombolytic, anticoagulant or antiplatelet action increase the damaging effect on the gastrointestinal mucosa;
- selective serotonin reuptake inhibitors (against the background of synergism with the drug) may increase the risk of bleeding from the upper gastrointestinal tract;
- digoxin reduces its renal excretion, so the risk of overdose increases;
- insulin, oral hypoglycemic agents (sulfonylurea derivatives) enhance their hypoglycemic effect;
- valproic acid increases its toxicity;
- NSAIDs, high doses of salicylic acid derivatives, as a result of synergistic action, increase the risk of ulcerogenic effect and gastrointestinal bleeding;
- ibuprofen reduces the cardioprotective effect of the drug;
- ethanol causes a mutual reinforcement of effects, which increases the risk of damage to the gastrointestinal mucosa and lengthening of bleeding time.
The combination of the drug with diuretics, angiotensin-converting enzyme inhibitors, benzbromarone, probenecid, systemic glucocorticosteroids (except for hydrocortisone) may weaken their action.
Analogs
Analogs of Godasal are: tablets - Alka-Prim, Next.
Terms and conditions of storage
Keep out of the reach of children.
Store at a temperature of 15-25 ° C, protected from moisture and light.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
