Brufen SR
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9.and storage conditions
- 10. Terms of dispensing from pharmacies
Prices in online pharmacies:
from 276 rubles.
Buy
Brufen SR is a non-steroidal anti-inflammatory drug (NSAID) that has antipyretic, analgesic, anti-inflammatory effects.
Release form and composition
Dosage form - tablets of prolonged action, film-coated: white, oblong, red-brown inscription on one side - BRUFEN RETARD (14, 10 or 7 pieces in a blister, in a cardboard box 1, 2, 3, 4, 5 or 6 blisters; 60 or 100 pcs. In a white plastic bottle, in a cardboard box 1 bottle).
1 tablet contains:
- active substance: ibuprofen - 800 mg;
- auxiliary components: Opadry white M-1-7111V, xanthan gum, stearic acid, povidone, hypromellose, colloidal silicon dioxide, brown Opacode S-1- 9460HV ink, talc.
Indications for use
- pain syndrome of mild and moderate severity: postoperative pain, migraine, headache, primary dysmenorrhea, toothache, panniculitis, myalgia, neuralgia;
- inflammatory diseases of the pelvic organs: algomenorrhea, adnexitis;
- inflammatory and degenerative pathologies: rheumatoid arthritis (including Still's syndrome or juvenile rheumatoid arthritis), articular syndrome with exacerbation of gout, osteoarthritis, psoriatic arthritis, spondylosis, Bechterew's disease (ankylosing spondylitis);
- diseases of periarticular tissues, including rheumatic genesis: capsulitis (periarthritis of the shoulder scapula), bursitis, tenosynovitis, tendinitis, tendovaginitis, sciatica, back pain;
- damage to soft tissues: hematomas, inflammation of the musculoskeletal system and soft tissues of traumatic etiology, sprains, dislocations.
Contraindications
- incomplete or complete combination of recurrent polyposis of the nose and paranasal sinuses, bronchial asthma and intolerance to acetylsalicylic acid or other NSAIDs (including history);
- severe heart failure;
- confirmed hyperkalemia;
- active liver disease;
- severe liver failure;
- kidney disease in a progressive form;
- renal failure with creatinine clearance (CC) less than 30 ml / min;
- blood coagulation disorders (including hemophilia, hypocoagulation), hemorrhagic diathesis;
- intracranial hemorrhage;
- a history of perforation or gastrointestinal bleeding caused by taking NSAIDs during previous therapy;
- intestinal diseases of inflammatory genesis;
- Crohn's disease, a recurrent form of gastric ulcer and duodenal ulcer or gastrointestinal bleeding, ulcerative colitis (including history);
- condition after coronary artery bypass grafting;
- III trimester of pregnancy;
- period of breastfeeding;
- age up to 12 years;
- hypersensitivity to the components of the drug.
With caution, Brufen SR should be prescribed to patients with a single episode in history of erosive and ulcerative pathology of the gastrointestinal tract (including gastric and duodenal ulcers), gastritis, colitis, enteritis, heart failure, arterial hypertension, coronary heart disease (including allergic anamnesis), bronchial asthma, chronic rhinitis, liver failure, chronic renal failure (CC 30-60 ml / min), diabetes mellitus, autoimmune diseases of connective tissue (including systemic lupus erythematosus), with cerebrovascular diseases, peripheral arterial disease, dyslipidemia or hyperlipidemia, the presence of H. pylori infection, frequent alcohol consumption, smoking, severe forms of somatic pathologies,blood disease of unknown etiology (anemia, leukopenia), liver cirrhosis with portal hypertension, hyperbilirubinemia, nephrotic syndrome, dehydration, in the I-II trimesters of pregnancy, old age, with prolonged use of NSAIDs or concomitant therapy with oral glucocorticosteroids (including prednisolone), antiplatelet agents (including clopidogrel), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, paroxetine, fluoxetine, sertraline).antiplatelet agents (including clopidogrel), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, paroxetine, fluoxetine, sertraline).antiplatelet agents (including clopidogrel), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, paroxetine, fluoxetine, sertraline).
Method of administration and dosage
The tablets are taken orally, after meals, swallowing whole and drinking plenty of water.
Recommended dosage regimen: once 2 pcs., It is desirable to take the tablets before bedtime. In the period of severe and acute conditions, it is possible to increase the daily dose up to 3 pieces, divided into 2 doses. The maximum daily dose is 3 pcs. (2400 mg).
For elderly patients, dose adjustment is required only in the presence of impaired renal and / or liver function, the dose is selected individually.
Side effects
- from the nervous system: often - dizziness, headache; infrequently - drowsiness, paresthesia; rarely - optic neuritis;
- from the gastrointestinal tract: often - abdominal pain, nausea, vomiting (including bloody), diarrhea, dyspepsia, flatulence, melena, gastrointestinal bleeding, constipation; infrequently - ulceration of the oral mucosa, stomach and / or duodenal ulcer, gastritis, perforation of the gastrointestinal tract (GIT) mucosa; very rarely - pancreatitis; frequency unknown - aphthous stomatitis, exacerbation of colitis and Crohn's disease;
- infectious diseases: infrequently - rhinitis; rarely - aseptic meningitis;
- from the blood and lymphatic system: rarely - anemia (including hemolytic and aplastic), neutropenia, thrombocytopenia, agranulocytosis, leukopenia;
- from the side of the psyche: infrequently - anxiety, insomnia; rarely - depression, confusion; frequency unknown - hallucinations;
- from the organ of hearing and labyrinth disorders: infrequently - noise or ringing in the ears, hearing impairment, vertigo;
- on the part of the organ of vision: infrequently - visual impairment; rarely toxic optic neuropathy;
- from the side of the vessels: very rarely - increased blood pressure (BP);
- from the heart: very rarely - myocardial infarction, exacerbation of heart failure;
- from the immune system: rarely - anaphylactic reaction;
- from the respiratory system, chest and mediastinal organs: infrequently - bronchospasm, exacerbation of bronchial asthma, dyspnea;
- from the hepatobiliary system: infrequently - jaundice, hepatitis, abnormal liver function; very rarely - liver failure;
- from the urinary system: infrequently - tubulointerstitial nephritis (including nephritis of allergic etiology), renal failure, nephrotic syndrome;
- dermatological reactions: often - rash; infrequently - itchy skin, hemorrhagic rash, urticaria, photosensitivity, angioedema; very rarely - bullous dermatosis (including Stevens-Johnson syndrome), exudative erythema multiforme, Lyell's syndrome (toxic epidermal necrolysis);
- general disorders: often - increased fatigue; rarely - edema.
special instructions
An increase in the dose of the drug increases the likelihood of gastrointestinal ulceration, bleeding or perforation in elderly patients or patients with a history of complications such as bleeding or perforation of peptic ulcer disease, so treatment should be started with the lowest dose. In addition, in this category of patients and patients with concomitant therapy with acetylsalicylic acid (at a low dose) or other drugs that increase the risk of gastrointestinal pathologies, it is recommended to concomitantly prescribe proton pump inhibitors, misoprostol or other gastroprotective agents.
Patients should be warned about the need to see a doctor if unusual symptoms appear in the abdominal cavity, especially if gastrointestinal bleeding is detected.
Diagnosed gastrointestinal ulceration or bleeding requires discontinuation of Brufen CP.
With autoimmune pathologies of connective tissue (including systemic lupus erythematosus), taking the drug increases the risk of developing aseptic meningitis.
In hepatic, renal or heart failure, the shortest possible course of therapy should be used at the lowest effective dose. The deterioration of renal function occurs with the simultaneous use of several analgesics.
With a history of heart failure or hypertension, long-term treatment or taking high (2400 mg) doses increases the risk of arterial thrombotic complications (including myocardial infarction, stroke).
In case of uncontrolled arterial hypertension, heart failure, coronary heart disease, peripheral arterial disease and / or cerebrovascular pathologies, the presence of risk factors for the development of cardiovascular diseases, ibuprofen should be prescribed only after a careful assessment of the balance of benefits and risks.
If symptoms of hypersensitivity (skin rash, mucosal lesions) appear, the tablets should be discontinued.
With significant dehydration, the risk of developing renal failure increases, especially in children and adolescents.
Since against the background of the use of Brufen CP, the process of platelet aggregation slows down, in patients without concomitant pathologies, this can increase the bleeding time.
Prescribing the drug to elderly patients requires special care due to the risk of developing adverse reactions.
It is recommended to be careful when driving vehicles and mechanisms.
Drug interactions
With the simultaneous use of Brufen SR:
- selective inhibitors of cyclooxygenase-2 and other NSAIDs can cause an additive effect;
- acetylsalicylic acid increases the risk of unwanted effects;
- cardiac glycosides, due to a decrease in the glomerular filtration rate, increase their concentration level in blood plasma;
- probenecid slows down the elimination of ibuprofen;
- cyclosporine and tacrolimus increase the risk of nephrotoxicity;
- selective serotonin reuptake inhibitors and antiplatelet agents (including clopidogrel, ticlopidine) increase the risk of gastrointestinal bleeding;
- lithium preparations reduce the rate of their elimination;
- antihypertensive drugs, diuretics, beta-blockers reduce their antihypertensive effect, in addition, diuretics increase the risk of nephrotoxic effects of ibuprofen;
- glucocorticosteroids increase the likelihood of ulcers or bleeding from the gastrointestinal tract;
- anticoagulants (including warfarin, heparin) increase their effect (monitoring of blood coagulation parameters is required);
- methotrexate reduces the rate of tubular secretion and decreases its clearance;
- zidovudine increases the risk of hematologic toxicity;
- aminoglycosides reduce their excretion;
- sulfonylurea preparations can enhance their effect, causing hypoglycemia;
- quinolone antibiotics increase the risk of seizures;
- inhibitors of the isoenzyme CYP2C9 enhance the effect of ibuprofen, therefore it is recommended to reduce its dose, especially when combined with voriconazole or fluconazole;
- cholestyramine reduces the absorption of ibuprofen in the gastrointestinal tract;
- ginkgo biloba extract may increase the risk of bleeding.
Analogs
Analogues of Brufen SR are: Ibuprofen, MIG 400, Nurofen, Nurofen Forte.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Brufen SR: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Brufen SR 0.8 g prolonged-release film-coated tablets 14 pcs. 276 r Buy |
|
Brufen SR tablets p.o. with prolonged release. 800 mg 14 Pcs. 307 r Buy |
|
Brufen SR 0.8 g prolonged-release film-coated tablets 28 pcs. 445 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
