Adiuretin SD - Instructions For Use, Indications, Doses, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Adiuretin SD

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Analogs
9. 9. Terms and conditions of storage
10. 10. Terms of dispensing from pharmacies

Adiuretin SD is a vasopressin-like drug.

Release form and composition

• Solution for injection (1 ml in ampoules, 5 ampoules in a package);
• Nasal drops (5 ml in dropper bottles, 1 bottle per package).

Active ingredient: desmopressin acetate:

• 1 ml solution for injection - 4 μg;
• 1 ml nasal drops - 100 mcg (1 drop - 5 mcg).

Indications for use

For injection solution:

• Diabetes insipidus (diagnosis and treatment);
• Von Willebrand disease;
• Hemophilia;
• Acute polyuria after pituitary surgery.

For nasal drops:

• Bed-wetting;
• Diabetes insipidus;
• Study of the concentration ability of the kidneys.

Contraindications

Absolute:

• Anuria;
• Fluid retention of various etiologies, including chronic heart failure;
• Conditions accompanied by a reduced relative osmotic density of blood plasma, including psychogenic and habitual polydipsia;
• Hypersensitivity to drug components.

Method of administration and dosage

Solution for injection

In this dosage form, Adiuretin SD is administered subcutaneously, intramuscularly or intravenously.

Recommended doses:

• Diabetes insipidus - 0.025 mcg / kg (2000-4000 mcg for adults and 400 mcg for children) 2 times a day (morning and evening). Doses of solution over 1 ml are administered as a slow intravenous drip infusion;
• Hemophilia A and von Willebrand disease: adults and children older than 11 months - 0.3 μg / kg as an intravenous infusion (in 50 ml of 0.9% sodium chloride solution) for 15-30 minutes. Children under 11 months of age with these diseases are not prescribed the drug.

In case of diabetes insipidus in the form of a solution for injection, Adiuretin is prescribed in case of impossibility of intranasal administration of the drug.

Nasal drops In this dosage form, Adiuretin is administered intranasally.

Recommended doses:

• Bedwetting: 2-10 drops at night;
• Diabetes insipidus: 1-3 drops 2-3 times a day;
• Acute central polyuria: 2 drops. If within 1 hour the normalization of the balance (fluid intake in the form of infusion and diuresis) does not occur, it is recommended to transfer the patient to an injection of the drug (usually intravenous);
• When studying the concentration ability of the kidneys: the usual dose is 3 drops (15 mcg), children over 1 year old - 2-3 drops (10-15 mcg) before the test. Immediately after the instillation of the drug, the patient must empty the bladder, and during the test and within 4 hours after its completion (about 8 hours in total), limit the intake of fluid into the body. During the next 4 hours of using the drug, urine samples are collected every hour to determine osmolarity. The test must be repeated if the test results in a decrease in the concentration of the kidneys.

Side effects

When using Adiuretin SD, the following side effects may develop: headache, cramping abdominal pain, nausea, vomiting, excessive sweating, difficulty urinating, and irritation of the nasal mucosa (when using nasal drops).

special instructions

The study of the concentration ability of the kidneys should be carried out by a nephrologist.

In children under 1 year old, a test using adiuretin diabetes is performed in exceptional cases. This is due to the fact that the drug used in high doses at this age can lead to the development of seizures and other mental and neurological symptoms.

In the case of a test in children under 1 year old, during the time of urine collection, it is necessary to completely exclude fluid intake.

Drug interactions

With the simultaneous use of dopamine, a mutual strengthening of the pressor effect is noted. If it is necessary to prescribe this combination, treatment should be carried out under close monitoring of the patient's condition.

Analogs

Analogues of Adiuretin SD are: Adiuretin, Apo-Desmopressin, Desmopressin, Vazomirin, Minirin, Nativa, Nurem, Presyneks, Emosint.

Terms and conditions of storage

Store in a dark place, out of reach of children, at a temperature of 5-15 ºС.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!