Fosamax
Instructions for use:
- 1. Indications for use
- 2. Contraindications for use
- 3. Side effects
- 4. Method of application, dosage
- 5. Overdose
- 6. Drug interactions
- 7. Application during pregnancy
- 8. Reviews
- 9. Analogs
- 10. Special instructions
Prices in online pharmacies:
from 415 rub.
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Fosamax is an inhibitor of bone resorption of the bisphosphanate group. The preparation contains the active ingredient - sodium alendronate. Localized in foci of active bone resorption, the drug inhibits this pathological process caused by osteoclasts, while not directly affecting the formation of new bone tissue. The processes of formation and resorption of bone tissue are interrelated, therefore, under the influence of Fosamax, bone formation is also reduced, but to a lesser extent than the process of resorption. The result is a progressive increase in bone mass. During treatment with this drug, normal bone tissue is formed, into the structure of which the pharmacologically inactive alendronate is embedded. At a therapeutic dosage, Fosamax does not cause osteomalacia. This drug has proven itself in the treatment of postmenopausal osteoporosis in women,significantly increasing bone density, due to which the reviews about Fosamax are positive. Clinical research data indicate a high activity of the drug.
When taken orally, Fosamax at a dosage of 5-70mg 2 hours before a regular breakfast, bioavailability is about 0.6%. With a later intake, bioavailability decreases by 40%. When Fosamax is taken simultaneously with food or after a meal, its bioavailability is negligible. There is no data on the ability of the drug to be metabolized in the human body.
In the amount of 50%, the drug is excreted by the kidneys. The terminal half-life of Fosamax is about 10 years, which indicates its release from the bone.
Indications for the use of Fosamax
The instructions for Fosamax indicate the following indications for use:
- postmenopausal osteoporosis in women (prevention of fractures, in particular of the femur, compression fractures of the spine);
- prevention of the development of osteoporosis with the risk of its occurrence in women during menopause (reducing the likelihood of fractures);
- therapy of osteoporosis in men (prevention of fracture development);
- treatment of glucocorticoid-induced osteoporosis;
- therapy of Paget's bone disease.
Contraindications to the use of Fosamax
According to the instructions for Fosamax, this drug is contraindicated for:
- individual intolerance to the components;
- diseases of the esophagus that slow down its emptying (achalasia, strictures);
- hypocalcemia;
- inability to stand or sit upright for half an hour.
Side effects
When using Fosamax, the following side effects have been reported:
- from the gastrointestinal tract: ulcers, erosion of the esophagus, vomiting, nausea, gastritis, esophagitis, melena, perforation, gastric and duodenal ulcers, including peptic ulcer disease (a reliable relationship with the use of the drug has not been established), esophageal strictures, local osteonecrosis of the jaw associated with previous tooth extraction;
- from the muscular and skeletal system: bone pain, myalgia, joint pain, joint swelling;
- on the part of the skin: erythema, skin rash, photosensitivity, alopecia, itching, extremely rarely - severe allergic processes (epidermal necrolysis, Stevens-Johnson syndrome);
- from the senses: episcleritis, scleritis, uveitis;
- from the side of the central nervous system: dizziness, impaired taste;
- others: hypocalcemia, peripheral edema.
Side effects are often the reason for negative reviews of Fosamax from patients. To prevent side effects of the drug, strict medical supervision is required when using it. When using the drug according to the instructions, Fosamax is quite well tolerated. Mild side effects that do not require discontinuation of the drug develop more often.
Method of application, dosage
Fosamax is for oral use. You must take the drug at least half an hour before eating or drinking. Drink with plain water only. Any other beverages will reduce the absorption of Fosamax.
To prevent irritation of the esophagus, it is recommended to follow these instructions when taking Fosamax: take a pill in the morning immediately after getting out of bed; should be taken with a full glass of plain water, without chewing or dissolving the tablet in the mouth; it is not recommended to go to bed before the first meal (at least 30 minutes). Do not take Fosamax before getting out of bed, as well as before going to bed.
In case of insufficient intake of vitamin D and calcium, it is recommended to take appropriate medications in parallel.
The therapeutic dosage of Fosamax for osteoporosis is 70 mg (1 tablet) once a week.
The dosage for the prevention of osteoporosis is 5 mg per day.
The dosage for glucocorticoid-induced osteoporosis is 5 mg per day.
The dosage of Fosamax for the treatment of Paget's bone disease is 40 mg per day for 6 months.
Overdose
With an overdose of Fosamax and analogues, symptoms of hypocalcemia, hypophosphatemia, lesions of the upper gastrointestinal tract occur. In case of an overdose, the patient must take antacids or milk to bind alendronate. Vomiting should not be induced (possible damage to the esophageal mucosa). There is no specific treatment.
Fosamax drug interactions
Fosamax absorption may be impaired while taking antacids, calcium supplements and other oral medications. The interval between taking Fosamax and other drugs should be more than 30 minutes. With the simultaneous use of glucocorticoids, no significant drug interactions have been identified.
The use of Fosamax during pregnancy
The use of Fosamax during pregnancy and lactation is contraindicated.
Reviews
This drug has a high ability to restore bone tissue, which has been proven in a number of clinical trials, so the reviews about Fosamax are positive from doctors and patients. When using the drug according to the instructions and in an adequate dosage, the risk of developing severe side effects is minimal.
Fosamax's analogs
There are the following analogues of Fosamax: Alendronat, Alental, Ostalon, Osterapar, Strongos, Tevanat, Forosa.
special instructions
When using Fosamax and analogues, there is a risk of damage to the upper gastrointestinal tract. Patients should be warned of this risk. When characteristic symptoms appear, medical attention is needed. The risk of developing severe gastrointestinal tract damage is significantly higher in patients who violate the recommendations for the use of Fosamax or continue to take it after the first symptoms of gastrointestinal mucosal lesions appear.
If you accidentally miss the next dose of Fosamax (in the mode of 1 tablet per week), it is recommended to take the next tablet the next morning. Subsequently, it is recommended to return to the selected schedule for taking the drug. You cannot take 2 tablets in one day.
Fosamax is used solely as directed by a physician and under strict medical supervision.
Before using the drug, it is recommended to study the instructions for Fosamax.
Fosamax: prices in online pharmacies
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Drug name Price Pharmacy |
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Fosamax 70 mg tablets 4 pcs. 415 RUB Buy |
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Fosamax 70mg tablets 4 pcs. 416 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
