Troxymethacin
Troxymetacin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Troximethacin
ATX code: M01AB51
Active ingredient: indomethacin + troxerutin (Indomethacin + Troxerutin)
Manufacturer: CSSPC OUI Pharmaceutical, Co. Ltd. (CSPC OUYI Pharmaceutical, Co. Ltd.) (China)
Description and photo update: 2020-25-02
Prices in pharmacies: from 185 rubles.
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Troxymethacin is a topical anti-inflammatory drug containing a combination of indomethacin with troxerutin.
Release form and composition
Dosage form - gel for external use, from yellow-brown to yellow, transparent, homogeneous (in a cardboard box 1 aluminum tube containing 40 g of gel, and instructions for the use of Troxymetacin).
Composition of 1 g of gel:
- active substances: indomethacin - 30 mg; troxerutin - 20 mg;
- Auxiliary components: purified water - 110 mg; dimethyl sulfoxide - 150 mg; isopropanol - 150 mg; macrogol-400 - 522 mg; sodium benzoate - 2.5 mg; disodium edetate - 0.5 mg; carbomer - 15 mg.
Pharmacological properties
Pharmacodynamics
Troxymethacin is a topical combination drug containing a non-steroidal anti-inflammatory agent, an indoleacetic acid derivative - indomethacin, and an angioprotector - troxerutin.
The pharmacological action of the drug is due to the following properties of its active ingredients:
- indomethacin: has a pronounced anti-inflammatory, analgesic and decongestant effect, due to which the pain syndrome is relieved, swelling decreases and the regeneration time of the affected tissues is reduced. Through the reversible blockade of cyclooxygenase 1 and 2, its main mechanism of action is realized, associated with the suppression of prostaglandin synthesis;
- troxerutin (trihydroxyethylrutinoside): bioflavonoid with angioprotective action. Reduces capillary permeability, has venotonic properties, blocks the venodilating effect of acetylcholine, bradykinin and histamine. In relation to the peri-venous tissue, it exhibits anti-inflammatory activity, reduces capillary fragility, and to some extent has an antiplatelet effect. Against the background of various pathological changes associated with venous insufficiency, it improves trophism and reduces edema.
When Troxymethacin gel is applied to the skin, the inflammatory edematous reaction is suppressed, pain and temperature decrease in the inflamed foci, both on the surface and in depth, since it penetrates deeply and reaches the blood vessels located there. The drug has a pronounced capillaroprotective and venotonic effect.
Pharmacokinetics
Due to the gel base, the release and solubility of the active components of Troxymetacin - troxerutin and indomethacin - are provided. This dosage form provides good absorption of substances from the skin surface and their therapeutic efficacy.
In the subcutaneous tissue and periarticular tissues, close to therapeutic concentrations are created when the gel is applied to the skin. The penetration of the active components of the drug into the systemic circulation has no clinical significance.
Indications for use
Gel Troxymetacin is prescribed for the symptomatic treatment of the following diseases / conditions:
- varicose veins (chronic venous insufficiency of the lower extremities) - as part of complex therapy, to relieve pain, a feeling of heaviness and swelling of the legs;
- periarthritis, fibrositis, bursitis, tendovaginitis (rheumatic lesions of soft tissues);
- post-phlebitis conditions, superficial phlebitis, thrombophlebitis;
- postoperative edema, sprains, dislocations, contusions.
Contraindications
Absolute:
- violation of the integrity of the skin;
- III trimester of pregnancy;
- lactation period;
- age up to 14 years (due to the lack of clinical experience in using the gel);
- established hypersensitivity to drug components and non-steroidal anti-inflammatory drugs (NSAIDs).
Relative (the use of Troxymetacin requires special care and careful medical supervision):
- the presence of polyps on the nasal mucosa;
- allergic rhinitis;
- bronchial asthma;
- combination therapy with other NSAIDs.
Troxymetacin, instructions for use: method and dosage
Troxymetacin gel is intended for topical use.
A single dose should be applied in a thin layer and rubbed into the skin of painful areas of the body. For one procedure, 4–5 cm of gel squeezed out of the tube is enough. The frequency of application of the drug is 3-4 times a day.
The maximum daily amount of gel should not exceed 20 cm. The duration of the course of treatment is no more than 10 days.
Side effects
Troxymethacin is very well tolerated.
Local reactions are possible in the form of manifestations of hypersensitivity from the skin: rash, itching, redness, contact dermatitis, a feeling of warmth and burning at the site of application of the gel.
Overdose
With topical use of Troxymetacin, no cases of overdose have been reported.
Patients who accidentally swallow a large amount of the drug may develop a burning sensation in the mouth, nausea, vomiting, and profuse salivation.
It is recommended to flush the mouth and stomach, symptomatic treatment is prescribed if necessary.
special instructions
It is important to apply Troxymetacin only to intact skin areas and avoid contact with mucous membranes and eyes. An occlusive dressing should not be applied over the gel.
If the drug gets on the mucous membranes, open wounds or eyes, symptoms of local irritation appear - pain, burning, redness and tearing. In such cases, the affected area is washed with a large amount of saline or distilled water until the signs of irritation diminish or disappear.
Dimethyl sulfoxide and benzoate are present as auxiliary components in the composition of the drug, which can irritate the skin.
Influence on the ability to drive vehicles and complex mechanisms
Local application of Troxymethacin does not adversely affect the rate of psychophysical reactions and the ability to concentrate, which are necessary when performing potentially hazardous activities, including when driving and working with moving mechanisms.
Application during pregnancy and lactation
There is no clinical experience of using Troxymetacin during pregnancy and during breastfeeding, sufficient to confirm its safety in these cases. The drug should be used only when its potential therapeutic benefit outweighs the expected risks to the fetus or newborn.
Pediatric use
The drug is not prescribed to children under the age of 14, since there is no clinical experience with its use in patients of this age group.
Drug interactions
It was found that Troxymethacin gel can enhance the effect of drugs that cause photosensitization.
No clinically important interactions with other drugs have been recorded.
Analogs
Analogues of Troximetacin are Indovazin, Reparil-Gel N, Indovenol, Troxevenol, Venitan, Venolife, Hepatrombin, Detragel, Troxevasin NEO, Troxerutin Vramed, Trombless Plus, etc.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Troxymetacin
Patients leave mixed reviews about Troxymetacin. In one case, the drug was described as effectively relieving inflammation and pain relief. Another indicated that the analgesic effect was mild and did not provide sufficient relief from pain. The advantages include the neutral smell of the gel, as well as the fact that it is very well absorbed into the skin and does not contaminate clothes. There are no complaints about negative side reactions.
Price for Troxymetacin in pharmacies
The approximate price for Troxymetacin, gel for external use, 2%, for 1 tube containing 40 g, is 193 rubles.
Troxymetacin: prices in online pharmacies
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Drug name Price Pharmacy |
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Troxymetacin gel for external use 40 g 1 pc. RUB 185 Buy |
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Troxymetacin gel for external use approx. tube 40g 264 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
