Tolterodine
Instructions for use:
- 1. Pharmacological action of the substance
- 2. Release form
- 3. Analogs
- 4. Indications for use
- 5. Method of application
- 6. Contraindications
- 7. Side effects
- 8. Drug interactions
Tolterodine is a compound that is a competitive blocker of m-cholinergic receptors and is part of drugs used in the treatment of urological diseases.
Pharmacological action of the substance tolterodine
The substance tolterodine, which is part of various drugs, is an antagonist of m-cholinergic receptors, which are localized in the salivary glands and the urinary bladder, and has a cholinolytic and antispasmodic effect.
The active 5-hydroxymethyl derivative of tolterodine is highly specific for muscarinic receptors, does not affect other receptors and, in contrast to the receptors of the salivary glands, is selective for the receptors of the bladder.
According to the instructions, tolterodine, which is part of antispasmodic drugs, not only reduces the activity of the bladder, but also reduces detrusor pressure and salivation, helps to weaken and disappear urinary incontinence and increases the interval between urination.
Release form
According to the instructions, tolterodine is a part of Detrusitol, Urotol and Roliten preparations, produced in the form of tablets and capsules.
Tolterodine analogs
Detrusitol, Urotol and Roliten are analogues of tolterodine-containing preparations in terms of the active substance. By the mechanism of action and belonging to the same pharmacological group, drugs are referred to as analogues of tolterodine-containing drugs:
- Vesicar;
- Enablex;
- Driptan;
- Novitropane;
- Spasm-lit;
- Spazmex;
- Toviaz.
Indications for the use of tolterodine
According to the instructions, tolterodine is prescribed for the treatment of overactive bladder, which manifests itself in the form of urinary incontinence or frequent urge to urinate.
Method of administration of tolterodine
In accordance with the instructions, tolterodine-containing preparations are taken orally 2 mg twice a day. In the presence of hepatic or renal failure in a patient, as well as in the development of side effects, the dose of drugs is reduced by half (1 mg twice a day). The duration of treatment with drugs containing tolterodine is from three to six months.
Contraindications
In accordance with the instructions, tolterodine is contraindicated for use in case of hypersensitivity to the substance, urinary retention, refractory myasthenia gravis, angle-closure glaucoma, severe ulcerative colitis and megacolon.
Side effects of tolterodine
The use of drugs, which include the substance tolterodine, according to reviews, causes side effects from various body systems, namely:
- Visual impairment, dizziness, headache, xerophthalmia, drowsiness and fatigue (nervous system and sensory organs);
- Arterial hypertension (cardiovascular system);
- Dry mouth, nausea, dyspepsia, constipation, flatulence, diarrhea, and abdominal pain (gastrointestinal tract);
- Urinary tract infections and dysuria (genitourinary system).
Also, drugs containing tolterodine are said to cause allergic reactions and flu-like symptoms, weight gain, sinusitis, bronchitis and dry skin.
Drug interactions
The combined use of tolterodine with anticholinergics enhances the therapeutic effect of the substance and increases the risk of side effects. The combined use of tolterodine with muscarinic cholinergic receptor agonists reduces the effect of the substance.
With the concurrent use of tolterodine with fluoxetine, a significant inhibition of the metabolism of tolterodine in extensive metabolizers is observed.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
