Ovitrel
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Prices in online pharmacies:
from 2530 rub.
Buy
Ovitrel is a luteinizing drug of recombinant choriogonadotropin alpha, an analogue of human chorionic gonadotropin (hCG).
Release form and composition
- Solution for subcutaneous administration: clear or slightly opalescent liquid, colorless or light yellow (0.5 ml each in a colorless glass syringe complete with an injection needle, 1 set in a plastic container, 1 container in a cardboard box);
- Lyophilisate for the preparation of a solution for subcutaneous administration: powder or porous mass of almost white or white color (0.25 mg in vials, 1, 2 or 10 vials complete with an ampoule of solvent (1, 2 or 10 ampoules, respectively) in plastic containers, 1 container in a carton box).
1 syringe with a volume of 0.5 ml contains:
- Active ingredient: choriogonadotropin alpha - 0.25 mg (6500 International Units (IU));
- Auxiliary components: methionine, mannitol, poloxamer 188, sodium hydroxide, phosphoric acid, water for injection.
1 bottle contains:
- Active ingredient: choriogonadotropin alpha - 0.25 mg (6500 IU);
- Auxiliary components: phosphoric acid, sucrose, sodium hydroxide in the amount necessary to maintain the pH level.
Solvent: water for injection.
Indications for use
Ovitrel is used in the protocol of ovulation induction with multiple follicle maturation (superovulation) during ART (assisted reproductive technologies), including in vitro fertilization, to induce the final maturation of follicles and the formation of a corpus luteum after stimulation with gonadotropins.
Also indications for the use of the drug are anovulatory or oligo-ovulatory infertility, in which Ovitrel is used to stimulate the ovaries in order to obtain mature follicles and luteinization at the end of the process of stimulating follicular growth.
Contraindications
- Vaginal bleeding of unexplained origin;
- Ectopic pregnancy during the previous 3 months;
- Uterine fibroids incompatible with pregnancy;
- Tumors in the pituitary gland and hypothalamus;
- Ovarian tumors not associated with polycystic ovarian cysts;
- Primary egg failure;
- Cancer of the breast, uterus, or ovary;
- Thromboembolism;
- Congenital defects in the development of the genitals, which are incompatible with pregnancy;
- Postmenopause;
- Hypersensitivity to the components of the drug.
Ovitrel is used with caution if patients have serious systemic diseases, the exacerbation of which may be triggered by pregnancy.
Method of administration and dosage
Solution for subcutaneous administration
The drug is administered subcutaneously. Each syringe is used for a single use only.
Recommended dosage regimen depending on indications:
- Application in the ovulation induction protocol: the contents of the syringe (0.25 mg) are injected once 24-48 hours after the last injection of follicle-stimulating hormone (FSH) or luteinizing hormone (LH), provided that the optimal level of follicle development is achieved;
- Anovulatory or oligo-ovulatory infertility: the contents of the syringe (0.25 mg) are injected once 24-48 hours after the optimal level of follicle development is achieved. On the day of injection of the drug and the next day, sexual intercourse is recommended.
Lyophilisate for preparation of a solution for subcutaneous administration The solution
prepared from a lyophilisate is injected subcutaneously.
The recommended single dose is 0.25 mg, the frequency of injections is determined by the attending physician, depending on the indications and the chosen therapy regimen.
For independent use of Ovitrel, patients need to study the instructions and act in accordance with the guidelines:
- The injection must be carried out observing the rules of asepsis and antiseptics;
- For the injection, prepare, spreading on a clean surface, two swabs soaked in alcohol and a pre-filled or ready-to-use syringe;
- The injection must be carried out in the area of the body selected on the recommendation of the attending physician (front of the thigh or abdomen). Wipe the injection site with a swab with alcohol, pull the disinfected skin area with your fingers, insert the needle into the skin fold at an angle of 45-90 °, gently pressing the plunger, slowly inject the entire volume of the solution, carefully remove the needle, then wipe the injection site with a second swab with alcohol. It is required to avoid getting the solution into the vein;
- After the procedure, the used syringe should be placed in a container for the disposal of sharps; the unused volume of the drug must be destroyed.
With the introduction of an increased dose of Ovitrel or in case of a missed injection, the patient should seek the advice of the attending physician.
Side effects
- Reproductive system: often - OHSS (ovarian hyperstimulation syndrome); rarely - breast tenderness, severe OHSS;
- Digestive system: often - abdominal pain, nausea, vomiting; rarely diarrhea;
- Central nervous system: often - headache; rarely - anxiety, irritability, fatigue, depression;
- Local reactions: often - pain and hyperemia in the injection area;
- Skin: very rarely - mild reversible skin rash;
- Other: often - tiredness; very rarely - mild hypersensitivity reactions.
special instructions
Before starting therapy with Ovitrel, it is required to establish the causes of infertility in a woman and her sexual partner and to assess possible risk factors in case of pregnancy. It is necessary to take into account the presence of tumors of the hypothalamus and pituitary gland, adrenal insufficiency, clinically pronounced hypothyroidism, hyperprolactinemia, as well as the specific methods of treatment used.
Due to the large number of follicles maturing at the same time, women are at risk of developing OHSS when the ovaries are stimulated. As a result of clinical studies, it was found that OHSS (in most episodes of moderate to mild severity) was observed in approximately 4% of cases. Severe OHSS can be a serious complication of stimulation. Rarely, due to severe OHSS, the following complications are possible: acute respiratory distress syndrome, hemoperitoneum, thromboembolism, ovarian torsion. In the protocol for stimulating follicular growth to reduce the risk of OHSS, it is recommended to closely monitor the response of the ovaries using ultrasound and determine the level of estradiol in the blood before and during therapy.
During the course of stimulation, the risk of multiple pregnancies increases in comparison with the natural process of fertilization; in most cases of stimulated pregnancies, twins are born. When using methods of assisted reproduction, the number of children born corresponds to the number of embryos transferred into the uterine cavity.
After the treatment of anovulatory infertility (including the use of assisted reproductive technologies), according to statistics, the number of miscarriages exceeds the average for the population, but is comparable to other types of infertility.
The introduction of the drug can affect the immunological picture of the level of hCG in urine and serum for 10 days and give a false positive reaction in the case of a pregnancy test.
Ovitrel may slightly stimulate thyroid function.
It is necessary to inform the doctor about cases of increased side effects and about all adverse reactions not described in the instructions.
Drug interactions
There are no data on the interaction of Ovitrel with other medicinal substances / drugs. Despite this, the patient should inform the attending physician about all medications, including over-the-counter, currently taken or recently taken.
Analogs
There is no information about Ovitrel analogues.
Terms and conditions of storage
Store the drug in its original packaging, out of the reach of children, at a temperature of 2-8 ° C, do not freeze.
It is allowed to store the drug at temperatures up to 25 ° C (outside the refrigerator) for 30 days, within the shelf life. After this period, the unused solution should be destroyed.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Ovitrell: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Ovitrel 250 mcg / 0.5 ml solution for subcutaneous administration 0.5 ml 1 pc. 2530 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
