Reosorbilact

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Reosorbilact: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Instructions for the use of Rheosorbilact: method and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. For violations of liver function
12. Drug interactions
13. Analogs
14. Terms and conditions of storage
15. Terms of dispensing from pharmacies
16. Reviews of Reosorbilact
17. Price of Reosorbilact in pharmacies

Latin name: Reosorbilact

ATX code: B05XA31

Active ingredient: Calcium chloride + Potassium chloride + Magnesium chloride + Sodium lactate + Sodium chloride + Sorbitol (Calcium chloride + Potassium chloride + Magnesium chloride + Sodium lactate + Sodium chloride + Sorbitol)

Manufacturer: LLC "Yuria-Pharm" (Ukraine)

Description and photo update: 2018-24-10

Rheosorbilact is a plasma-substituting multicomponent solution of multifunctional action for replenishing the volume of circulating fluid and maintaining it, providing a pronounced detoxification and powerful hemodynamic effect, improving microcirculation and rheological properties of blood.

Release form and composition

Dosage form of the drug Rheosorbilact - solution for infusion: clear colorless liquid (200 or 400 ml in vials, in a cardboard box 1 vial).

1 liter of solution contains:

active ingredients: sorbitol - 60 g; sodium lactate - 19 g; sodium chloride - 6 g; calcium chloride in terms of dry matter - 0.1 g; potassium chloride - 0.3 g; magnesium chloride on a dry matter basis - 0.2 g;
excipient: water for injection.

Ionic composition of the preparation (mmol / l; mg / ml):

Na ⁺ - 278.16; 6.395;
K ⁺ - 4.02; 0.157;
Ca ²⁺ - 0.9; 0.036;
Mg ²⁺ - 2.1; 0.051;
Cl ^- - 112.69; 3.995;
CH ₃ CH (OH) COO ^- - 175.52; 15,635.

The theoretical osmolarity of Rheosorbilact is 900 mOsm / L.

Pharmacological properties

Pharmacodynamics

Rheosorbilact is a saline solution similar in composition to blood plasma, capable of supporting the vital activity of the body or isolated organs for some time without causing physiological changes. It has a detoxifying, rheological, anti-shock and alkalizing effect. The basic pharmacologically active substances of the solution are sodium lactate and sorbitol.

Pharmacological properties of the main components of the drug:

sorbitol: metabolized in the liver to fructose, which is then transformed into glucose and then converted into glycogen. Part of the sorbitol goes to cover the urgent energy needs of the body, the other part is deposited in the form of glycogen, as a reserve. Due to the disaggregant effectiveness of isotonic sorbitol solution, Rheosorbilact improves microcirculation and perfusion in tissues;
sodium lactate: correction of metabolic acidosis with sodium lactate occurs as it is metabolized, more slowly than with bicarbonate solution, without causing sudden pH fluctuations. The effect of sodium lactate appears after 20-30 minutes from the moment of drug administration;
sodium chloride: is a plasma-substituting agent that has a rehydration and detoxification effect, eliminating the lack of sodium and chlorine ions formed as a result of various pathological conditions;
calcium chloride: replenishes the deficiency of calcium ions necessary for the implementation of the process of propagation of nerve impulses, muscle contraction (skeletal and smooth), myocardial function, osteogenesis, blood coagulation. It reduces the permeability of cells and vascular walls, prevents the development of inflammatory reactions, improves the body's resistance to infections and is able to significantly enhance phagocytosis;
potassium chloride: helps to restore water and electrolyte balance. It has a negative chrono- and batmotropic effect, in high doses it has a negative foreign, dromotropic and moderate diuretic effect. Participates in the transmission of nerve impulses. Promotes an increase in the level of acetylcholine and potentiates the excitation of the sympathetic division of the autonomic nervous system. With myasthenia gravis, muscular dystrophy improves the contraction of skeletal muscles.

Pharmacokinetics

Sorbitol, getting into the circulatory system, quickly enters into general metabolic processes. From 80 to 90% of sorbitol is utilized in the liver and deposited in the form of glycogen, up to 5% is deposited in the heart muscle, brain tissues and skeletal muscles, from 6 to 12% is eliminated in the urine.

Sodium lactate, included in the general circulation, reacts with water and carbon dioxide to form sodium bicarbonate, which increases the alkaline reserve of the blood. Only half of the administered sodium lactate is active, namely its isomer L. Isomer D - its other part - is not subject to metabolism and is eliminated in the urine.

Sodium chloride is removed from the vascular bed quickly, for a short time increasing the volume of circulating blood (BCC), and increases diuresis.

Indications for use

traumatic, operational, hemolytic, toxic and burn shock, acute blood loss, burn disease - in order to improve capillary blood flow (for prevention and therapy);
chronic hepatitis in the acute stage;
infectious diseases accompanied by intoxication;
sepsis;
thrombosis, thrombophlebitis, endarteritis - in order to improve venous and arterial blood flow (for prevention and therapy);
Raynaud's disease;
preoperative preparation, postoperative period.

Contraindications

Absolute:

thromboembolism, cerebral hemorrhage, grade III arterial hypertension, cardiovascular decompensation and other conditions / diseases in which large volumes of fluid are contraindicated;
alkalosis;
individual hypersensitivity to any component of the drug.

Reosorbilact is prescribed with caution to patients with peptic ulcer disease, impaired liver function, hemorrhagic colitis.

Instructions for the use of Rheosorbilact: method and dosage

Reosorbilact solution is intended for intravenous jet or drip administration.

Recommended dosing regimen for adult patients and children over 12 years of age according to indications:

traumatic, burn, postoperative and hemolytic shock: from 600 to 1000 ml (at the rate of 10-15 ml / kg of body weight) once, then again. They start with a jet injection of the solution, after which they switch to drip;
chronic hepatitis in the acute stage: 400 ml (at the rate of 6–7 ml / kg of body weight) drip, then again;
acute blood loss: from 1500 to 1800 ml (at the rate of up to 25 ml / kg of body weight); infusion is recommended to be carried out in a specialized ambulance at the pre-hospital stage;
preoperative preparation and the period after various surgical interventions: 400 ml (at the rate of 6-7 ml / kg of body weight) drip, once or daily for 3-5 days;
thrombobliterating diseases of blood vessels: at the rate of 8-10 ml / kg of body weight, drip, 1 time in 2 days, a course of up to 10 infusions.

For children under 6 years of age, the drug is recommended to be administered at a dose of 10 ml / kg of body weight, at the age of 6–12 years - at a dose of ½ the dose for adults.

Side effects

Due to the use of Rheosorbilact, it is possible to increase the pH of the blood and other body tissues due to the accumulation of alkaline substances (alkalosis) and the appearance of allergic reactions manifested by skin rash, itching.

Overdose

A symptom of an overdose of Rheosorbilact is alkalosis, which quickly passes on its own, provided that the infusion is stopped immediately.

special instructions

According to the instructions, Rheosorbilact should be used under the control of blood electrolyte and acid-base state, as well as an assessment of the functional state of the liver.

The solution is administered with caution to patients with calculous cholecystitis.

Application during pregnancy and lactation

There is no data.

Pediatric use

In pediatric practice, the solution is used according to indications in volumes depending on the child's age: up to 6 years - at the rate of 10 ml / kg of body weight, 6-12 years - at a dose corresponding to half the dose for adults, over 12 years old - at a dose for adults …

For violations of liver function

Rheosorbilact is prescribed with caution to patients with impaired liver function.

Drug interactions

It is forbidden to mix Rheosorbilact solution with phosphate- and carbonate-containing solutions and use it as a carrier solution for other medicines.

Analogs

Analogs of Rheosorbilact are: Ringer's lactate with magnesium, Sorbilact, Gemodez, Reopolyglukin, Regidron, etc.

Terms and conditions of storage

Store at temperatures from 2 to 25 ° C, protected from light and moisture. Keep out of the reach of children.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Reosorbilact

According to doctors and patients, the drug cleanses the blood and liver well, removes toxins from the body, relieves symptoms of intoxication, improves blood circulation, therefore, almost all reviews about Rheosorbilact are positive. Also, many consider its cost to be low.

Price for Rheosorbilact in pharmacies

The approximate price for Reosorbilact (for 1 bottle of 200 ml) is ~ 350 rubles.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!