Creon 25000 - Instructions For Use Of Capsules, Price, Analogs, Reviews

Table of contents:

Creon 25000 - Instructions For Use Of Capsules, Price, Analogs, Reviews
Creon 25000 - Instructions For Use Of Capsules, Price, Analogs, Reviews

Video: Creon 25000 - Instructions For Use Of Capsules, Price, Analogs, Reviews

Video: Creon 25000 - Instructions For Use Of Capsules, Price, Analogs, Reviews
Video: Creon 25000 Capsule (Pancreatin 300mg)- Uses, Side effects, Warnings, Substitute | हिन्दी 2023, March

Creon 25000

Creon 25000: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  1. 9. Application during pregnancy and lactation
  2. 10. Use in childhood
  3. 11. Drug interactions
  4. 12. Analogs
  5. 13. Terms and conditions of storage
  6. 14. Terms of dispensing from pharmacies
  7. 15. Reviews
  8. 16. Price in pharmacies

Latin name: Kreon 25000

ATX code: A09AA02

Active ingredient: Pancreatin (Pancreatin)

Manufacturer: Solvay Pharmaceuticals, Germany

Description and photo update: 2018-22-10

Prices in pharmacies: from 454 rubles.


Enteric capsules Creon 25000
Enteric capsules Creon 25000

Creon 25000 is a digestive enzyme preparation.

Release form and composition

Dosage form Creon 25000 - enteric capsules: size No. 0, hard gelatinous, body with a transparent structure, colorless, cap - opaque, orange-brown color, inside the capsule - light brown minimicrospheres (20, 50 or 100 pcs. In vials from high density polyethylene, white with a screw cap made of polypropylene; in a cardboard box or box 1 bottle).

1 capsule contains:

  • active substance: pancreatin - 0.3 g, which is equivalent to the content of 25000 U (enzyme action unit) Ph. Eur. (European Pharmacopoeia) lipase, 18,000 U Ph. Eur. amylase, 1000 U Ph. Eur. proteases;
  • auxiliary components: cetyl alcohol, macrogol 4000, dimethicone 1000, triethyl citrate, hypromellose phthalate;
  • shell composition: gelatin, sodium lauryl sulfate, iron dye red oxide (E172), titanium dioxide (E171), iron dye yellow oxide (E172).

Pharmacological properties


Creon 25000 - improves the process of food digestion in adults and children, reducing the symptoms of pancreatic enzyme deficiency (changes in the frequency and consistency of stools, flatulence). Pancreatic enzymes, facilitating the breakdown of fats, proteins and carbohydrates, contribute to their complete absorption in the small intestine.

The minimicrospheres containing porcine pancreatin are in an acid-fast enteric coating and are enclosed in a gelatin capsule. Rapid dissolution of the capsule in the stomach releases hundreds of minimicrospheres, which mix with food and go from the stomach to the intestines. Thorough mixing of the minimicrospheres with the intestinal contents allows the enzymes to be evenly distributed in the intestine.

Lipolytic, amylolytic and proteolytic activity of enzymes leads to the breakdown of fats, proteins and carbohydrates. The substances obtained as a result of their cleavage are partially immediately absorbed, the other part is further broken down by intestinal enzymes.


For the manifestation of their therapeutic effect, the pancreatic enzymes do not require absorption, their activity is fully realized in the lumen of the gastrointestinal tract. According to their chemical structure, pancreatic enzymes are proteins, therefore, in the process of passing through the gastrointestinal tract, they are degraded to peptides and amino acids and absorbed.

Indications for use

The use of Creon 25000 is shown as a replacement therapy for enzymatic (exocrine) pancreatic insufficiency, which is caused by a decrease in its enzymatic activity against a background of impaired production, regulation of secretion and delivery of pancreatic enzymes, or increased destruction of enzymes in the intestinal lumen.

The following conditions / diseases of the gastrointestinal tract can cause pancreatic enzyme deficiency:

  • cystic fibrosis;
  • chronic pancreatitis;
  • pancreas cancer;
  • obstruction of the ducts of the pancreas or common bile duct (including with neoplasm);
  • Schwachman-Diamond syndrome;
  • partial gastric resection (including Billroth II surgery);
  • period after gastrectomy, pancreatic surgery;
  • resumption of nutrition after an attack of acute pancreatitis.


The use of the drug is contraindicated in case of established intolerance to its components.

With caution, Creon 25000 should be prescribed during pregnancy.

Instructions for the use of Creon 25000: method and dosage

Capsules are taken orally, with each meal or immediately after meals (including light snacks), swallowed whole with plenty of liquid.

If it is impossible to swallow (small children, elderly patients), the capsules can be carefully opened and their contents mixed with soft, cool food that does not require chewing, or liquid. The acidity (pH) of food or liquid must be below 5.5. The minimicrospheres can be mixed with applesauce, yogurt or apple, orange, pineapple juice with a pH of less than 5.5. Do not expose the contents of the capsules to hot food or liquids! Any of the mixtures should be prepared immediately before taking.

The dose of Creon 25,000 is selected individually, taking into account clinical indications, diet and severity of the disease.

Recommended dosage for cystic fibrosis for each meal:

  • adults and children over the age of 4 years: at the rate of 500 lipase units per 1 kg of body weight;
  • children under 4 years of age: the initial dose is 1000 lipase units per 1 kg of body weight.

When determining the dose, it is necessary to use the results of studies of feces for steatorrhea. The dose should ensure that the patient maintains adequate nutritional status. Usually it is no more than 10,000 lipase units per 1 kg of body weight per day, or 4000 lipase units per 1 g of fat consumed.

In other conditions accompanied by exocrine pancreatic insufficiency, the dose that should be taken with the main meal can be 25,000–80,000 U of lipase, with a light snack - half the individual dose.

The use of Creon 25000 in children must strictly comply with the doctor's prescription.

Side effects

  • from the gastrointestinal tract: very often - pain in the abdomen; often - bloating, nausea, vomiting, diarrhea, or constipation; frequency unknown - fibrosing colonopathy (the formation of strictures of the ileum, blind and / or colon while taking high doses of pancreatin in cystic fibrosis).
  • dermatological reactions: infrequently - rash; frequency unknown - itching, urticaria;
  • from the immune system: the frequency is unknown - anaphylactic reactions with hypersensitivity.


Symptoms of a pancreatin overdose are hyperuricemia and hyperuricosuria.

Treatment: discontinuation of capsules and symptomatic therapy.

special instructions

It is necessary to start using Creon 25000 only after consulting a doctor.

While taking high doses of pancreatin preparations (more often when exceeding 10,000 lipase units per 1 kg of body weight per day) there is a risk of developing strictures of the ileum, cecum and colon. Patients with cystic fibrosis who experience unusual symptoms or abdominal discomfort require a medical examination to rule out the presence of fibrosing colonopathy.

As a result of mixing the contents of the capsules with food or liquid, destruction of the protective enteric coating of the minimicrospheres may occur when crushing or chewing. Premature release of enzymes in the mouth reduces the effectiveness of the drug and can irritate the mucous membranes. Therefore, with this method of taking the drug, it is necessary to make sure that there are no residues of minimicrospheres in the oral cavity.

You should ensure the constant intake of a sufficient amount of fluid, especially in patients with a tendency to increased its loss. Not getting enough fluid can cause or worsen constipation.

The development of unwanted gastrointestinal disorders is associated to a greater extent with the underlying disease.

Allergic reactions are mainly manifested by negative effects on the part of the skin.

Influence on the ability to drive vehicles and complex mechanisms

According to the instructions, Creon 25000 may have a slight effect on the patient's ability to drive vehicles and mechanisms.

Application during pregnancy and lactation

It is assumed that there is no toxic effect of porcine pancreatic enzymes on the reproductive function of the body and the development of the human fetus. However, the appointment of the drug during gestation should be made only in special cases when the expected therapeutic effect for the mother significantly exceeds the possible threat to the fetus.

The reception of Creon 25000 is shown during lactation, since it does not imply a harmful effect on the child through breast milk.

If enzyme therapy is necessary during pregnancy or breastfeeding, the dose of the drug should sufficiently maintain an adequate nutritional status.

Pediatric use

The use of the drug in pediatrics is allowed only as directed by a doctor.

Drug interactions

The interaction of Creon 25000 with substances / preparations with the simultaneous use of other drugs has not been established.


The analogues of Creon 25000 are: Gastenorm, Mezim, Micrasim, Pancreasim, Penzital, Panzinorm, PanziKam, Pangrol, Pancreatin, Enzistal.

Terms and conditions of storage

Keep out of the reach of children. Store in tightly closed original containers at temperatures up to 25 ° C.

Shelf life - 36 months, after the first opening - 3 months.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Creon 25000

Reviews of Creon 25,000 are mostly positive. Patients report an improvement and restoration of the digestive process after undergoing a course of therapy. Capsules are easy to take, and in case of problems with swallowing, their contents can be taken without a capsule shell, which is especially convenient when treating children. The drug is effective and safe. There are practically no descriptions of adverse reactions caused by taking it.

The only drawback indicated is the high cost.

Price for Creon 25000 in pharmacies

The price of Creon 25,000 for 20 capsules per package is approximately 568 rubles.

Creon 25000: prices in online pharmacies

Drug name



Creon 25000 25000 IU enteric capsules 20 pcs.

454 RUB


Creon 25000 caps. ksh / solution 300mg n20

575 RUB


Creon 25000 25000 IU enteric capsules 50 pcs.

1016 RUB


Maria Kulkes
Maria Kulkes

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

Popular by topic