Mifegin Tablets - Instructions For Use, Reviews, Doses

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Mifegin

Instructions for use:

1. 1. Pharmacological action
2. 2. Release form
3. 3. Analogs
4. 4. Indications for use
5. 5. Contraindications
6. 6. Method of application
7. 7. Drug interactions
8. 8. Side effects
9. 9. Storage conditions

Mifegin is a drug for medical interruption of uterine pregnancy for up to 42 days and for preparing and starting the delivery process of a full-term pregnancy in case of problems with the fetus.

Mifegin, the active ingredient micronized mifepristone, is an antagonist of sex hormones, increases the contractility of the muscular component of the walls of the uterus and its tone.

Pharmacological action of Mifegin

Mifegin is a steroidal synthetic antigestagenic drug that blocks the action of the hormone progesterone at the receptor level, is gestagenically inert. Mifepristone counteracts glucocorticosteroids (GCS) at the receptor level.

Mifegin tablets increase the contractility of the muscular component of the uterine walls by stimulating the release of the main pro-inflammatory chemokine - interleukin 8 in the choriodecidual tissue. Mifepristone increases the sensitivity of the muscle tissue of the uterus to prostaglandins. To increase the effect, a course of synthetic prostaglandin analogs is prescribed simultaneously with Mifegin. As a result, scaly exfoliation of the amniotic membrane occurs and the prolapse (expulsion) of the ovum.

Release form

Mifegin tablets are biconvex, light yellow, code "167B" on one side. The active ingredient is micronized mifepristone 200 mg in 1 tablet.

Mifegin's analogs

Analogs of Mifegin tablets by the active ingredient - tablets: Agesta, Ginepristone, Ginestril, Zhenale, Miropriston, Mifeprex, Mifepristone, Mifolian, Pencrofton

There are no analogues of Mifegin in terms of the mechanism of action yet.

Indications for Mifegin's use

According to the instructions, Mifegin is recommended for interruption in the early stages (up to 42 days of amenorrhea) of uterine pregnancy.

Also, according to the instructions, Mifegin can be prescribed for the induction and preparation of labor in the event of intrauterine fetal death, when it is undesirable to use prostaglandin or oxytocin.

Contraindications

According to the instructions, Mifegin is not prescribed for general indications in the case of:

• Adrenal insufficiency;
• Acute or chronic renal failure;
• Acute or chronic liver failure;
• Porphyrias;
• Anemia;
• Hemostasis disorders;
• Taking anticoagulants;
• Long-term use of glucocorticoids;
• The presence of complex extragenital pathology;
• Hypersensitivity to any component of the drug.

With medical termination of pregnancy according to the instructions, Mifegin is not used in the case of:

• Suspected ectopic pregnancy;
• Pregnancy not confirmed by clinical studies;
• Absence of menstruation for more than 42 days;
• If pregnancy occurs after the abolition of hormonal contraceptives or during the use of intrauterine contraceptives;
• Inflammatory diseases of the genitourinary system;
• Smoking women over 35 years old, without the permission of the observing therapist.

When prescribing a drug for preparing and starting the labor process according to the instructions, Mifegin is not used in the case of:

• Severe gestosis, preeclampsia, eclampsia;
• Premature or post-term fetus;
• Placenta previa;
• If the size of the fetal head does not match the size of the woman's pelvis;
• Abnormal presentation of the fetus;
• Bloody discharge of unexplained etiology from the genital tract.

Chronic obstructive pulmonary diseases, arterial hypertension, chronic heart failure, arrhythmia are diseases in which Mifegin tablets should be prescribed with caution.

Method of using Mifegin

According to the instructions, Mifegin tablets are intended for oral administration. The drug can be used only in a hospital that has a license to provide medical services, appropriate medical equipment and specially trained medical personnel.

The scheme for using Mifegin tablets is determined by the attending physician.

Mifegin drug interactions

According to the instructions, Mifegin should not be taken simultaneously with non-steroidal anti-inflammatory drugs. You can start taking these drugs 8-12 days after taking mifepristone.

Side effects

According to reviews, Mifegin can cause not only systemic side reactions associated with taking mifepristone, but also undesirable effects directly from the therapy.

Undesirable systemic side effects due to taking Mifegin tablets, according to reviews, are manifested by general weakness, headache, dizziness, nausea, vomiting, diarrhea, fever, discomfort and pain in the lower abdomen.

Side effects of the treatment procedure when taking Mifegin, according to reviews, are usually manifested by bloody discharge from the genital tract, pain in the lower abdomen, inflammatory processes of the uterus and appendages.

Storage conditions

Mifegin tablets are a list A drug. Storage in a dry, dark place, out of reach of children. Shelf life - 3 years from the date of manufacture.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!