AzitRus - Instructions For Use, Indications, Doses, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

AzitRus

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Analogs
9. 9. Terms and conditions of storage
10. 10. Terms of dispensing from pharmacies

Prices in online pharmacies:

from 31 rub.

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AzitRus is an antibacterial drug with a bacteriostatic effect from the macrolide group (azalide), active against gram-positive microorganisms, with the exception of bacteria resistant to erythromycin.

Release form and composition

• Capsules: size No. 0, gelatinous, yellow; content - granules of almost white or white color (in blisters of 6 pcs., 1 package in a cardboard box);
• Powder for preparation of suspension for oral administration (for children): almost white or white, with the smell of orange; ready-made suspension - homogeneous, white with a yellowish tinge color (in single-dose bags of 4.2 g, in a carton pack 3 or 6 bags, a glass may be included; 100 mg / 5 ml - 17 g each, 200 mg / 5 ml - 25 g each in dark glass jars, in a pack of cardboard 1 can complete with a dosing spoon and a dispenser or a 2-sided dosing spoon).

Composition of 1 capsule:

• Active ingredient: azithromycin (in the form of a dihydrate) - 250 mg;
• Excipients: microcrystalline cellulose, calcium stearate, polyvinylpyrrolidone;
• The composition of the capsule shell: gelatin, propyl hydroxybenzoate, titanium dioxide, acetic acid, methyl hydroxybenzoate.

Composition of 1 package of powder:

• Active ingredient: azithromycin (in the form of a dihydrate) - 50, 100 or 200 mg;
• Excipients: sucrose, sodium saccharinate, sodium citrate (sodium citrate trisubstituted), Kollidon CL-M (crospovidone), orange food flavor.

Indications for use

AzitRus is used to treat infectious and inflammatory diseases of organs and systems caused by sensitive microorganisms:

• ENT organs and upper respiratory tract: sinusitis, tonsillitis, pharyngitis, tonsillitis, otitis media;
• Lower respiratory tract: bronchitis, exacerbation of chronic pneumonia, bacterial infections, including those caused by atypical pathogens of pneumonia;
• Skin and soft tissues: secondary infected dermatoses, impetigo, erysipelas;
• Urinary tract: urethritis (including gonorrheal);
• Female genital organs: cervicitis.

Also AzitRus is used to treat the following diseases:

• Scarlet fever;
• Erythema creeping (erythema migrans) - the initial stage of Lyme disease (tick-borne borreliosis);
• Diseases of the stomach and duodenum associated with the bacterium Helicobacter pylori (as part of complex therapy).

Contraindications

Absolute:

• Renal and hepatic impairment;
• Children's age: up to 6 months - for a suspension made from powder; up to 3 years and / or weighing less than 25 kg - for capsules;
• Lactation period;
• Hypersensitivity to drug components or other macrolides.

Carefully:

• Heart rhythm disorders;
• Pregnancy;
• Severe liver / kidney dysfunction in children.

Method of administration and dosage

AzitRus should be taken orally 1 time per day 1 hour before meals or 2 hours after meals.

Recommended dosages for adults, depending on the indication:

• Respiratory tract infections: 500 mg / day for a 3-day course;
• Skin and soft tissue infections, creeping erythema: 1st day - 1000 mg, 2-5 days - 500 mg each;
• Uncomplicated urethritis and / or cervicitis: 1000 mg once;
• Peptic ulcer and 12 duodenal ulcer caused by Helicobacter pylori (as part of a combination therapy): 1000 mg / day for 3 days.

Recommended doses for children:

• Respiratory tract, soft tissue and skin infections: on the 1st day 10 mg / kg, during the next 4 days - 5-10 mg / kg / day or 10 mg / kg 1 time per day for 3 days;
• Erythema creeping: 1st day - 20 mg / kg, 2-5 days - 10 mg / kg / day.

For children over 6 months old, AzitRus is prescribed in the form of a suspension made from powder.

Recommended daily (single) doses of the suspension depending on the child's body weight when using powder at a dose of 100 mg / 5 ml - azithromycin (suspension):

• 5 kg - 50 mg (2.5 ml);
• 6 kg - 60 mg (3 ml);
• 7 kg - 70 mg (3.5 ml);
• 8 kg - 80 mg (4 ml);
• 9 kg - 90 mg (4.5 ml);
• 10-14 kg - 100 mg (5 ml).

Recommended daily (single) doses of the suspension, depending on the child's body weight when using powder at a dose of 200 mg / 5 ml - azithromycin (suspension):

• 15-24 kg - 200 mg (5 ml);
• 25-34 kg - 300 mg (7.5 ml);
• 35-44 kg - 400 mg (10 ml);
• From 45 kg - doses for adults (from 500 to 1000 mg).

Rules for the preparation of a suspension for oral administration: pour a small amount of boiled and chilled water into a clean glass, pour out the contents of 1 packet and mix until a homogeneous suspension is obtained. After taking the drug, rinse the cup with clean water, dry it and store in a clean dry place.

Side effects

• Allergic reactions: rash, pruritus, urticaria, angioedema; in children - itching, urticaria, conjunctivitis;
• From the digestive system:> 1% - abdominal pain, nausea, diarrhea; ≤1% - melena, vomiting, flatulence, increased activity of hepatic transaminases, cholestatic jaundice; in children (≤1%) - change in taste, loss of appetite, candidiasis of the oral mucosa, constipation, gastritis;
• From the urinary system: ≤1% - nephritis;
• From the side of the central nervous system: ≤1% - headache, dizziness, drowsiness; in children (≤1%) - sleep disorders, anxiety, hyperkinesia, neurosis, headache (in the treatment of otitis media);
• From the side of the cardiovascular system: ≤1% - chest pain, palpitations;
• From the reproductive system: vaginal candidiasis;
• Others: photosensitivity, asthenia.

special instructions

You should not take AzitRus with food.

If the next dose is missed, the missed dose should be taken as soon as possible, and the next dose should be taken at intervals of 24 hours.

With the concomitant administration of antacids, a break of at least 2 hours should be observed between doses of drugs.

After the abolition of AzitRus, hypersensitivity reactions may persist in some patients; in these cases, it is recommended to carry out specific therapy under medical supervision.

When prescribing high doses of the drug, you can take film-coated tablets, AzitRus Forte at a dose of 500 mg.

Drug interactions

• Aluminum and magnesium containing antacids, ethanol and food: absorption of azithromycin slows down and decreases;
• Digoxin: its concentration in blood plasma increases;
• Ergotamine, dihydroergotamine: their toxic effect increases (dysesthesia, vasospasm);
• Triazolam: its clearance decreases and its pharmacological action increases;
• Lincosamines: the effectiveness of azithromycin decreases;
• Tetracycline, chloramphenicol: the effect of azithromycin is enhanced;
• Indirect anticoagulants, felodipine, methylprednisolone, cycloserine, and drugs subject to microsomal oxidation (oral hypoglycemic agents, ergot alkaloids, cyclosporine, bromocriptine, terfenadine, disopyramide, hexobarbital, phenytoin, valprosylinic acid) their excretion slows down, plasma concentrations and toxicity increase.

Since macrolides, interacting with warfarin, enhance its anticoagulant effect, a similar effect can be expected with the simultaneous administration of AzitRus, therefore, the prothrombin time should be carefully monitored.

Analogs

AzitRus analogs are: Azivok, Azimycin, Azitrox, Azitral, Azicid, Azithromycin, Azithromycin-OBL, Zitrocin, Sumazid, Sumamecin, Sumamox, Sumamed, Sumamed Forte, Hemomycin, Ecomed.

Terms and conditions of storage

Store in a dry, dark place protected from children at temperatures up to 25 ºС.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

AzitRus: prices in online pharmacies

Drug name Price Pharmacy

AzitRus 50 mg powder for suspension for oral administration 4.2 g 3 pcs. RUB 31 Buy

AzitRus 200 mg powder for suspension for oral administration 4.2 g 3 pcs. 34 rbl. Buy

AzitRus 100 mg powder for suspension for oral administration 4.2 g 3 pcs. RUB 36 Buy

AzitRus 250 mg capsules 6 pcs. RUB 80 Buy

AzitRus 250 mg capsules 12 pcs. 94 r Buy

AzitRus forte 500 mg film-coated tablets 3 pcs. 102 RUB Buy

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!