Azilekt - Instructions For Use, Indications, Doses, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Azilekt

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Analogs
9. 9. Terms and conditions of storage
10. 10. Terms of dispensing from pharmacies

Prices in online pharmacies:

from 5505 rub.

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Azilekt is an antiparkinsonian drug; selective irreversible inhibitor of monoamine oxidase type B.

Release form and composition

Azilect is produced in the form of tablets: almost white or white, round, flat-cylindrical, with a bevel, engraving "GIL 1" on one side (10 pcs. In blisters, 1, 3 or 10 blisters in a cardboard box).

The composition of 1 tablet includes:

• Active ingredient: rasagiline - 1 mg (rasagiline mesylate - 1.56 mg);
• Auxiliary components: talc - 4 mg; mannitol - 159.24 mg; colloidal silicon dioxide - 1.2 mg; corn starch - 20 mg; stearic acid - 4 mg; pregelatinized corn starch 20 mg

Indications for use

Azilect is prescribed for the treatment of Parkinson's disease (as monotherapy or simultaneously with levodopa drugs).

Contraindications

Absolute:

• Hepatic impairment of moderate to severe degree (classes B and C on the Child-Pugh scale);
• Combined use with other monoamine oxidase inhibitors (including drugs and food supplements containing St. John's wort), pethidine. The interval between the end of rasagiline therapy and the appointment of these drugs should be at least 14 days;
• Age under 18 (no safety profile);
• Hypersensitivity to drug components.

Relative (Azilect is prescribed with caution in the presence of the following diseases / conditions):

• Mild hepatic failure (class A on the Child-Pugh scale);
• Combined use with selective serotonin reuptake inhibitors (including fluoxetine, fluvoxamine), selective serotonin and norepinephrine reuptake inhibitors, tetracyclic and tricyclic antidepressants, powerful inhibitors of the CYP1A2 isoenzyme.

Before prescribing Azilect to pregnant and lactating women, it is necessary to correlate the benefits for the mother with the possible harm to the health of the fetus / child (due to the lack of the necessary data).

Method of administration and dosage

Azilekt is taken orally, regardless of food intake.

The daily dose is 1 tablet (1 mg). The drug is used for monotherapy or as part of a complex treatment with levodopa.

Long-term therapy is shown.

Side effects

Violations that occur while taking Azilect can develop with different frequencies: very often (≥1 / 10), often (≥1 / 100 to <1/10), infrequently (≥1 / 1000 to <1/100), rarely (≥1 / 10,000 to <1/1000), very rare (<1/10,000).

Monotherapy:

• Immune system: often - allergic reactions;
• Nervous system: very often - headache; infrequently - a violation of cerebral circulation;
• Cardiovascular system: often - angina pectoris; infrequently - myocardial infarction;
• Digestive system: often - bloating;
• Respiratory system: often - rhinitis;
• Musculoskeletal system: often - musculoskeletal pain, neck pain, arthritis;
• Urinary system: often - urge to urinate;
• Hematopoietic system: often - leukopenia;
• Parasitic and infectious diseases: often - influenza;
• Subcutaneous tissue and skin: often - dermatitis; infrequently - vesicular-bullous rash;
• Neoplasms (unspecified, malignant and benign, including polyps and cysts): often - skin cancer;
• Metabolism and nutrition: infrequently - decreased appetite;
• Mental disorders: often - depression, hallucinations;
• Hearing organ and labyrinthine disorders: often - vertigo;
• Organ of vision: often - conjunctivitis;
• Others: often - fever, malaise.

Application as adjunctive therapy:

• Cardiovascular system: infrequently - angina pectoris; often - orthostatic hypotension;
• Nervous system: very often - dyskinesia; often - dystonia, carpal tunnel syndrome, imbalance; infrequently - a violation of cerebral circulation;
• Digestive system: often - abdominal pain, constipation, nausea and vomiting, dry mouth;
• Musculoskeletal system: often - arthralgia, neck pain;
• Mental disorders: often - hallucinations, nightmares; infrequently - confusion of consciousness;
• Neoplasms (unspecified, malignant and benign, including polyps and cysts): infrequently - skin melanoma;
• Subcutaneous tissue and skin: often - rash;
• Nutrition and metabolism: often - decreased appetite;
• Others: often - weight loss, falls.

In Parkinson's disease, the following can be observed: confusion and hallucinations (according to post-registration experience against the background of rasagiline therapy).

The development of serious adverse reactions arising from combined use with selective serotonin reuptake inhibitors, selective serotonin and norepinephrine reuptake inhibitors, tetracyclic / tricyclic antidepressants and monoamine oxidase inhibitors is well known. During the period of post-registration studies, there were reports of cases of the development of serotonin syndrome, which manifested itself as agitation, confusion, rigidity, fever and myoclonus, in patients who were simultaneously taking antidepressants / selective serotonin and norepinephrine reuptake inhibitors and rasagiline.

In the post-registration period, cases of increased blood pressure (including individual cases of hypertensive crises) were recorded in patients using an indefinite amount of tyramine-rich foods (cheeses, chocolate, etc.) in their diet, as well as when using the ophthalmic vasoconstrictor tetrahydrozoline.

special instructions

There is evidence of cases of impulsive personality disorder in patients treated with dopamine receptor agonists and / or other dopaminomimetics. The same disorders were observed in the post-registration period when taking Azilect, in connection with which, during therapy, it is necessary to monitor the condition of the patients. Consideration should be given to the possibility of developing disorders such as increased libido, compulsive behavior, gambling addiction, obsessions, hypersexuality, impulsive behavior, and compulsive needs to buy or buy.

Combined use with sympathomimetics, dextromethorphan or complex cough medicines for oral or nasal administration containing ephedrine or pseudoephedrine is not recommended.

If any pathological changes in the skin appear, you should consult a doctor, since Parkinson's disease or (according to other sources) Azilect can lead to the development of skin cancer, in particular melanoma.

Disorders such as hallucinations and confusion can be a manifestation of the disease or be a side effect of Azilect.

Given the likelihood of developing significant adverse reactions from the central nervous system, during the period of therapy when driving vehicles and performing potentially hazardous activities, care must be taken until patients make sure that Azilekt does not have a negative effect on increasing concentration and speed of psychomotor reactions.

Drug interactions

With the combined use of Azilect with some drugs / substances, the following effects may be observed:

• Pethidine: development of serious adverse reactions (the combination is contraindicated);
• Other monoamine oxidase inhibitors (including drugs and food supplements containing St. John's wort): there is a high risk of severe hypertensive crisis (the combination is contraindicated);
• Fluoxetine or fluvoxamine: the likelihood of developing an interaction (the combination is not recommended; the interval should be observed after discontinuation of fluoxetine or fluvoxamine - 5 weeks, after discontinuation of Azilect - 14 days);
• Dextromethorphan, sympathomimetic drugs: potential for interactions (combination not recommended);
• Potent inhibitors of the isoenzyme CYP1A2: a change in the plasma concentration of rasagiline, in smokers - a decrease (the combination requires caution);
• Selective serotonin reuptake inhibitors, selective serotonin and norepinephrine reuptake inhibitors, tricyclic and tetracyclic antidepressants: development of serious adverse reactions (combination requires caution);
• Entacapone: increased clearance of rasagiline.

Analogs

Azilect's analogs are: Razagilin, Razagilina mesylate.

Terms and conditions of storage

Keep out of reach of children at temperatures up to 25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Azilekt: prices in online pharmacies

Drug name Price Pharmacy

Azilekt 1 mg tablets 30 pcs. RUB 5505 Buy

Azilekt 1 mg tablets 100 pcs. RUB 14381 Buy

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!