Tyrosol
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Prices in online pharmacies:
from 143 rub.
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Tyrozol is a drug with antithyroid action.
Release form and composition
The dosage form of Tyrozol is film-coated tablets: light yellow or gray-orange (5/10 mg), biconvex, round, with a line on one or two sides (5/10 mg), the core is almost white or white (10 or 25 pieces in blisters, 2, 4, 5 or 10 blisters in a cardboard box).
Composition of 1 tablet:
- active substance: thiamazole - 5 or 10 mg;
- auxiliary components (5/10 mg): hypromellose 2910/15 - 3/3 mg; cellulose powder - 10/10 mg; talc - 6/6 mg; lactose monohydrate - 200/195 mg; colloidal silicon dioxide - 2/2 mg; corn starch - 20/20 mg; sodium carboxymethyl starch - 2/2 mg; magnesium stearate - 2/2 mg;
- shell (5/10 mg): hypromellose 2910/15 - 3.21 / 3.21 mg; titanium dioxide - 1.43 / 0.89 mg; dye iron oxide yellow - 0.04 / 0.54 mg; dye iron oxide red - 0 / 0.004 mg; macrogol 400 - 0.79 / 0.79 mg; dimethicone 100 - 0.16 / 0.16 mg.
Indications for use
- thyrotoxicosis;
- long-term maintenance treatment of thyrotoxicosis, when, due to the general condition or individual reasons, it is impossible to perform radical treatment (in exceptional cases);
- treatment in the latent period of the action of radioactive iodine (carried out for 4-6 months before the onset of the action of radioactive iodine);
- preparation for therapy of thyrotoxicosis with radioactive iodine;
- preparation for surgical treatment of thyrotoxicosis;
- prevention of thyrotoxicosis against the background of the appointment of iodine preparations (including the use of iodine-containing X-ray contrast agents) in cases of the presence of autonomous adenomas, latent thyrotoxicosis, or a burdened history of thyrotoxicosis.
Contraindications
Absolute:
- agranulocytosis during previous use of carbimazole or thiamazole;
- cholestasis before starting therapy;
- granulocytopenia (including a history of indications);
- combined use with levothyroxine in pregnant women;
- rare hereditary diseases - galactose intolerance, glucose-galactose malabsorption syndrome or lactase deficiency;
- age up to 3 years;
- individual intolerance to the components of the drug, as well as thiourea derivatives.
Relative (diseases / conditions in which Tyrozol is prescribed with caution):
- a goiter of very large size with a narrowing of the trachea (short therapy is possible during the period of preparation for the operation);
- liver failure;
- pregnancy (the use of Tyrozol is possible after assessing the ratio of benefit to risk in a daily dose of up to 10 mg without levothyroxine sodium);
- lactation period (under the control of thyroid function in newborns).
Method of administration and dosage
Tyrozol is taken orally with a sufficient amount of liquid, preferably after meals. The tablets should not be chewed.
The daily dose can be taken in 1 dose or divided into 2-3 single doses. At the beginning of therapy, single doses during the day should be taken at a strictly defined time. The maintenance dose must be taken in 1 dose after breakfast.
The recommended scheme of Tyrosol application:
- thyrotoxicosis: 20-40 mg per day (depending on the severity of the condition) for a course of 3-6 weeks; after normalization of the thyroid gland parameters, the patient is transferred to maintenance therapy - 5–20 mg per day in combination with sodium levothyroxine;
- preparation for surgical treatment of thyrotoxicosis: 20–40 mg per day until the euthyroid state is reached, after which levothyroxine sodium is additionally prescribed; to reduce the time to prepare for the operation, additional use of beta-blockers and iodine preparations is possible;
- preparation for treatment with radioactive iodine: 20-40 mg daily until euthyroid state is reached;
- therapy in the latent period of radioactive iodine action: 5–20 mg per day (depending on the severity of the condition) for a course of 4–6 months (before the onset of radioactive iodine action);
- long-term thyreostatic maintenance therapy: 1.25–2.5–10 mg per day with additional intake of small doses of levothyroxine sodium; the duration of thyrotoxicosis therapy is 1.5–2 years;
- prevention of thyrotoxicosis when prescribing iodine preparations (including the use of iodine-containing X-ray contrast agents) with latent thyrotoxicosis, autonomic adenomas or thyrotoxicosis in history: 10–20 mg per day in combination with potassium perchlorate 1000 mg per day for 8–10 days before taking iodine-containing agents.
Children 3–17 years old Tyrozol is prescribed daily at an initial daily dose of 0.3–0.5 mg / kg, divided into 2–3 equal doses. The maximum recommended dose for children over 80 kg is 40 mg per day. The maintenance dose is 0.2–0.3 mg / kg per day. If necessary, levothyroxine sodium is additionally prescribed.
In pregnant women, Tyrozol can be used in the smallest doses: single - 2.5 mg, daily - 10 mg.
In patients with hepatic insufficiency, the drug is prescribed under close medical supervision in the minimum effective doses.
When preparing for surgery in patients with thyrotoxicosis, Tyrozol is used until the euthyroid state is reached for 3-4 weeks before the planned day of surgery (sometimes for a longer period). The drug is discontinued the day before the operation.
Side effects
Possible violations (> 10% - very often;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare):
- endocrine system: very rarely - autoimmune insulin syndrome with hypoglycemia;
- hematopoietic system: infrequently - agranulocytosis (symptoms of the disease can appear weeks / months after the start of therapy, which requires the abolition of Tyrozol); very rarely - thrombocytopenia, generalized lymphadenopathy, pancytopenia;
- digestive system: very rarely - vomiting, enlargement of the salivary glands;
- nervous system: rarely - a change in taste (is reversible), dizziness; very rarely - polyneuropathy, neuritis;
- musculoskeletal system: often - arthralgia (slowly progressive) without clinical signs of arthritis;
- allergic reactions: skin manifestations (in the form of itching, redness, rashes);
- skin and subcutaneous tissues: very rarely - alopecia, generalized skin rashes, lupus-like syndrome;
- liver and biliary tract: very rarely - toxic hepatitis, cholestatic jaundice;
- general reactions: rarely - weight gain, weakness, fever.
special instructions
With a significant increase in the thyroid gland, narrowing the lumen of the trachea, Tyrozol is prescribed for a short time in combination with sodium levothyroxine, since long-term treatment can lead to an increase in goiter and even greater compression of the trachea. Careful monitoring is required for the condition of patients, including control of the tracheal lumen and the level of thyroid-stimulating hormone.
During the use of the drug, it is necessary to regularly monitor the peripheral blood picture.
Therapy with thiamazole and thiourea derivatives can lead to a decrease in the sensitivity of thyroid tissue to radiation therapy.
With a sudden onset of symptoms of agranulocytosis (sore throat, difficulty swallowing, fever, signs of stomatitis, furunculosis), you should immediately cancel Tyrozol and consult a doctor for advice.
In cases of subcutaneous hemorrhage or bleeding of unclear etiology, vomiting or persistent nausea, generalized skin rash, itching, jaundice, severe pain in the epigastrium, severe weakness, Tyrozol is canceled.
With early termination of therapy, a relapse of the disease may occur.
Worsening of the course / appearance of endocrine ophthalmopathy is not a side effect of adequate treatment.
In rare cases, after the end of the use of Tyrozol, late hypothyroidism may develop. It is not among the side effects, but is associated with destructive and inflammatory processes in the tissues of the thyroid gland, which occur within the framework of the underlying disease.
Drug interactions
The effect of thiamazole with a lack of iodine is enhanced.
With the appointment of Tyrozol after the use of high doses of iodine-containing X-ray contrast agents, a weakening of the effect of thiamazole may be observed.
After the normalization of the serum content of thyroid hormones in the blood in the treatment of thyrotoxicosis, it may be necessary to reduce the doses of cardiac glycosides (digitoxin, digoxin), aminophylline, as well as to increase the doses of warfarin and other anticoagulants - coumarin and indandione derivatives.
With the combined use of Tyrozol with certain drugs / substances, the following effects may develop:
- sulfonamides, metamizole sodium and myelotoxic drugs: increased likelihood of leukopenia;
- beta-blockers, lithium preparations, reserpine, amiodarone: enhancement of the effect of thiamazole (dose adjustment may be required);
- gentamicin: enhancement of the antithyroid action of thiamazole;
- folic acid, leucogen: reducing the likelihood of leukopenia.
It is necessary to take into account that with thyrotoxicosis, an acceleration of metabolism and elimination of substances is observed, therefore, in some cases, it may be necessary to adjust the doses of other drugs.
Analogs
Tyrozol analogues are: Eutirox, Triiodothyronine, Tyro-4, L-Thyroxin, Bagotyrox, L-Tyrok, Propicil, Mercazolil, Iodomarin, Metizol, Iodbalans, Thiamazole, Mikroyodid.
Terms and conditions of storage
Store in a place protected from moisture at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Tyrozol: prices in online pharmacies
|
Drug name Price Pharmacy |
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Tyrozol 5 mg film-coated tablets 50 pcs. 143 r Buy |
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Tyrozol tablets p.p. 5mg 50 pcs. 175 RUB Buy |
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Tyrozol 10 mg film-coated tablets 50 pcs. 280 RUB Buy |
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Tyrozol tablets p.p. 10mg 50 pcs. 343 r Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
