Testosterone propionate
Testosterone propionate: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Testosterone Propionate
ATX code: G03BA03
Active ingredient: testosterone (testosterone)
Producer: JSC "DALKHIMPHARM" (Russia)
Description and photo update: 2018-26-10
Testosterone propionate is an androgenic drug.
Release form and composition
Dosage form of Testosterone propionate - solution for injection in olive oil 1% and 5%: oily liquid of light yellow or light green color, with a specific odor [1 ml in ampoules: in a cardboard box 10 ampoules complete with an ampoule knife / scarifier, or 5 ampoules in a blister strip, in a cardboard box 2 packs complete with an ampoule knife / scarifier (an ampoule knife / scarifier is inserted only in packs with a certain type of ampoule, without a break point / ring)].
Composition of 1 ampoule:
- active substance: testosterone propionate - 10 or 50 mg;
- auxiliary component: ethyl oleate.
Pharmacological properties
Pharmacodynamics
Testosterone propionate is a drug that has an androgenic and anabolic effect (that is, it regulates the function of the male sex glands and protein synthesis).
Testosterone stimulates the function and development of the vulva, seminal vesicles, prostate, and secondary male sexual characteristics. Provides stimulation of spermatogenesis, participates in the formation of male sexual behavior and the construction of the body constitution. Under its influence, the production of follicle-stimulating and luteotropic hormones decreases.
Testosterone is an antagonist of the female sex hormones estrogen. It has an antitumor effect on neoplasms in the mammary glands in women.
The drug has an anabolic effect and, as a result, reduces the amount of body fat, stimulates protein synthesis and retains in the body a number of elements necessary for it.
Under the influence of this hormone, muscle mass grows, the degree of calcium fixation in bones increases.
If the patient receives sufficient protein nutrition during the use of Testosterone propionate, the production of erythropoietin, one of the kidney hormones that controls erythropoiesis, is also stimulated.
Pharmacokinetics
After intramuscular or subcutaneous administration, testosterone is slowly absorbed, after which it enters the bloodstream and organs, in which it is restored to 5-α-dihydrotestosterone, which interacts with the receptors of the cell membrane, and then penetrates into the cell nuclei.
Testosterone is characterized by a high bond with plasma proteins - 98%. Metabolized in the liver. It is excreted mainly through the kidneys. In unchanged form, about 6% of the substance is excreted through the intestines.
Indications for use
For men:
- sexual underdevelopment;
- functional disorders in the reproductive system (including impotence associated with endocrine disorders, eunuchoidism, oligospermia);
- menopause (the period after 50 years, when men are no longer able to reproduce offspring) and associated nervous and vascular disorders;
- hypertrophy of the prostate;
- acromegaly (enlargement of internal organs, feet and hands, nose and lower jaw, metabolic disorders).
For women:
- breast and ovarian cancer in women under the age of 60; dysfunctional uterine bleeding in older women;
- climacteric vascular and nervous disorders (in the presence of contraindications to estrogenic or female sex hormone drugs).
Contraindications
- violations of the process of urination;
- hyperplasia of the prostate;
- cancer of the prostate or breast in a man;
- gynecomastia;
- diabetes;
- hypercalcemia;
- swelling;
- heart failure;
- myocardial infarction;
- severe asthenization;
- disruption of the kidneys and liver;
- pregnancy and breastfeeding;
- advanced age in men;
- hypersensitivity to Testosterone propionate.
Instructions for the use of Testosterone propionate: method and dosage
Testosterone propionate is intended for intramuscular or subcutaneous administration. A single dose is usually 1 ml of solution. The interval between injections is 1-2 days.
Recommended dosage regimens:
- eunuchoidism, underdevelopment of the sex glands, acromegaly: 25 mg of testosterone daily or 25-50 mg every 1-2 days. The duration of treatment is individual, depending on the severity of the effect. Later, the patient is transferred to maintenance therapy - 5-10 mg daily or every other day;
- hypertrophy of the prostate: 10 mg every other day for 1-2 months;
- impotence of endocrine origin, menopause in men: 10 mg daily or 25 mg 2-3 times a week for a course of 1-2 months.
The doctor determines the course of treatment for women individually, depending on the indications and severity of symptoms. In case of dysfunctional uterine bleeding, 1-2 ml of 1% solution is prescribed every other day. The course is 20-30 injections.
Side effects
- respiratory disorders, apnea;
- tendency to thrombosis;
- leg pain, arthralgia, convulsions;
- severe sweating, nervousness, dizziness, depression;
- weight gain;
- diarrhea, nausea, jaundice;
- itching, acne, seborrhea;
- local reactions (in the area of injections).
When using the drug in high doses, salt and water retention, increased sexual arousal are possible. Men may have frequent erections. Women may have masculinization (coarsening of the voice, growth of facial and body hair), atrophy (weight loss) of the mammary glands, pasty face (loss of elasticity and whitening of the facial skin against a background of mild edema).
In the case of the appointment of large doses of Testosterone propionate to women for the treatment of dysmenorrhea, it is possible to completely stop menstruation.
In boys and adolescents, the drug can accelerate puberty, promote enlargement of the genitals.
Overdose
When using the drug in high doses for a long time, the side effects and symptoms described above associated with androgen dependence occur. Treatment in this case should be suspended until stabilization of the condition, after which Testosterone propionate should be prescribed in lower doses.
In women, with an overdose, menstruation may stop.
special instructions
Doctors do not recommend the use of testosterone for muscle development and endurance.
Before prescribing the drug, men are shown a medical examination to exclude prostate cancer, since Testosterone propionate increases the risk of developing prostatic hyperplasia.
When administering the drug, care should be taken to prevent the solution from entering the vessels. In order to avoid the development of undesirable side effects, including local ones, it is recommended to introduce the agent very slowly.
During treatment, monitoring of the condition of patients suffering from migraine, kidney disease, arterial hypertension, heart failure, epilepsy is required.
Testosterone propionate increases the tendency to thrombosis, therefore, it should be used with caution in the treatment of patients who have recently undergone trauma or surgery.
In the case of prolonged therapy, it is necessary to monitor the following indicators: the functional state of the liver, testosterone concentration, hemoglobin level and hematocrit.
In children, testosterone can cause accelerated growth, premature closure of the growth zone of the pineal gland and too active maturation of bone tissue.
Influence on the ability to drive vehicles and complex mechanisms
During therapy, it is recommended to refrain from driving and working with potentially dangerous consequences.
Application during pregnancy and lactation
Pregnant and breastfeeding women are prohibited from taking the drug, since it has a teratogenic effect.
Pediatric use
There are no data on the safety of testosterone use in childhood, so the drug is not prescribed in pediatrics.
With impaired renal function
Testosterone propionate is contraindicated in renal impairment.
For violations of liver function
Testosterone propionate is contraindicated in liver dysfunction.
Use in the elderly
For men in old age, the drug is not prescribed.
Drug interactions
According to the instructions, Testosterone propionate enhances the effects of anabolic drugs, vitamins, oral anticoagulants and drugs containing phosphorus and calcium. Its effect is reduced by barbiturates, carbamazepine, phenytoin, phenylbutazone, rifampicin, ethanol.
With the simultaneous use of adrenocorticotropic hormone or corticosteroids, the risk of edema increases.
Under the influence of androgens, it is possible to increase the action of hypoglycemic drugs and insulin, which may require a decrease in their dose.
Testosterone slows down the elimination of cyclosporine.
Patients with severe hypogonadism Testosterone propionate is recommended to be used in combination with estrogens and agents that stimulate the function of the thyroid gland.
Analogs
Testosterone propionate analogs are: Andriol, Androzel, Nebido, Testoviron, Sinandron, etc.
Terms and conditions of storage
The shelf life is 5 years.
Store away from sunlight, out of reach of children at a temperature of 5–25 ° С.
Terms of dispensing from pharmacies
Dispensed by prescription.
Testosterone propionate reviews
Testosterone propionate reviews confirm its high efficiency when used according to indications. Patients note a significant improvement in their condition, but emphasize that in order to achieve the desired effect, it is necessary to strictly adhere to the treatment regimen prescribed by the doctor.
Despite the recommendations of doctors not to use this remedy to improve physical fitness, most often testosterone propionate reviews are left by men involved in sports. They write that under its influence muscle mass grows and muscle relief is actively increased, but the effect is short-lived.
The price of Testosterone propionate in pharmacies
The approximate price of Testosterone propionate is 1200 rubles per pack of 10 ampoules of 5% solution.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
