Equator
Instructions for use:
- 1. Pharmacological properties
- 2. Release form
- 3. Indications for use
- 4. Contraindications
- 5. Instructions for use
- 6. Side effects
Prices in online pharmacies:
from 511 rub.
Buy
Equator is a drug that lowers blood pressure.
Pharmacological properties of Equator
According to the instructions, Equator is a combined agent, it contains amlodipine and lisinopril.
Lisinopril is an ACE inhibitor. Its mechanism of action is associated with blocking the conversion of angiotensin II from angiotensin I in the renal tissue. This reduces the effect of aldosterone on water metabolism, increases the formation of prostaglandins.
Lisinopril lowers blood pressure by vasodilation (arteries dilate more than veins) and a decrease in total peripheral vascular resistance (OPSS). In addition, its effect on the heart is expressed in the fact that:
- Reduced preload;
- The pressure in the pulmonary capillaries decreases;
- The resistance of the heart muscle to stress increases;
- The minute volume of blood flow increases.
Regular long-term use of Equator tablets improves the blood supply to the heart and reduces its hypertrophy. It has been proven that drugs from a number of ACE inhibitors prolong life in the presence of chronic heart failure, slow down the development of left ventricular dysfunction after myocardial infarction.
An additional effect of lisinopril is to reduce albuminuria, which makes it possible to recommend it when arterial hypertension is combined with diabetic nephropathy, but it does not affect the glucose level at all.
Amlodipine is the second component of the Equator. This active ingredient is from the group of slow calcium channel blockers. Amlodipine reduces the transfer of calcium ions into the cells of smooth muscle fibers. Its effect on the cardiovascular system can be described as antianginal and antihypertensive. The principle of action of amlodipine in Equator tablets is similar to lisinopril - the systemic vascular resistance decreases and the blood supply to the myocardium improves.
The combination of two active agents in one preparation complements each other and eliminates unwanted side effects. So, calcium channel blockers usually retain water and sodium in the body, while ACE inhibitors, on the contrary, interfere with this process.
The action of the Equator according to the instructions begins in 1 hour, the maximum effect is visible 6 hours after administration. The therapeutic effect of the Equator, according to reviews, persists throughout the day.
With high blood pressure, the positive effect of the Equator according to the instructions is manifested in the first days of the beginning of its use; for a long-term permanent effect, it is necessary to take the drug constantly.
The Equator is excreted unchanged, it does not turn into metabolites in the body.
Release form
Equator is released in tablets of 5 and 10 mg (for amlodipine).
Indications for use of Equator
The drug is prescribed if necessary for combination therapy in case of high blood pressure.
Contraindications
You can not use the Equator if you are intolerant to it and other ACE inhibitors, with stenosis (narrowing of the outlet) of the aorta and mitral valve in case of its hemodynamic significance.
Contraindications to taking Equator tablets will be hereditary and idiopathic angioedema, hypertrophic cardiomyopathy with obstruction, marked decrease in blood pressure (systolic pressure below 90 mm Hg), heart failure after myocardial infarction, unstable angina pectoris, cardiogenic shock, pregnancy and pregnancy … Children under 18 years of age are not recommended to take Equator according to the instructions.
Caution in the use of Equator is required for bilateral renal artery stenosis, primary hyperaldosteronism, severe renal and hepatic dysfunction, after kidney transplantation, with hyperkalemia.
Instructions for use of Equator
The drug should be taken 1 time per day, in the morning, with water, without reference to food intake. In the initial period, the patient may be worried about a decrease in pressure while taking diuretics the day before, therefore, diuretics are canceled before treatment with Equator 2 to 3 days.
If the use of diuretics is still necessary, the dose of Equator is reduced to 0.5 tablets. During the course of therapy, it is periodically required to monitor kidney function, potassium and sodium levels in the blood.
Equator side effects
According to reviews, the Equator can sometimes give such undesirable reactions as headache, dizziness or coughing. They go away on their own and do not require discontinuation of the drug.
Equator: prices in online pharmacies
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Drug name Price Pharmacy |
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Equator 5 mg + 10 mg tablets 30 pcs. RUB 511 Buy |
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Equator 5 mg + 20 mg tablets 30 pcs. 522 RUB Buy |
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Equator tablets 5mg + 10mg 30 pcs. RUB 524 Buy |
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Equator 5 mg + 10 mg tablets 10 pcs. 649 r Buy |
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Equator tablets 10mg + 20mg 30 pcs. RUB 672 Buy |
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Equator 10 mg + 20 mg tablets 30 pcs. RUB 672 Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
