Cardilopin - Instructions For Use, Price, Tablet Analogs, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Cardilopin

Cardilopin: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Use in the elderly
14. 14. Drug interactions
15. 15. Analogs
16. 16. Terms and conditions of storage
17. 17. Terms of dispensing from pharmacies
18. 18. Reviews
19. 19. Price in pharmacies

Latin name: Cardilopin

ATX code: C08CA01

Active ingredient: amlodipine (Amlodipine)

Manufacturer: CJSC "Pharmaceutical Plant" EGIS "(Hungary)

Description and photo update: 2019-12-07

Prices in pharmacies: from 266 rubles.

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Cardilopin is a calcium channel blocker, an antihypertensive drug with an antianginal effect.

Release form and composition

The drug is available in the form of tablets: from white to yellowish-white, round, flat, with a chamfer, engraving "E" on one side, on the other - "251" (dosage 2.5 mg), "252" (dosage 5 mg) or "253" (dosage 10 mg) (10 pcs. in blisters, in a cardboard box 1, 2 or 3 blisters and instructions for use of Cardilopin).

1 tablet contains:

• active substance: amlodipine besylate - 3.475; 6.95 or 13.9 mg, which is equivalent to 2.5; 5 or 10 mg amlodipine, respectively;
• auxiliary components: sodium carboxymethyl starch (type A), microcrystalline cellulose, anhydrous colloidal silicon dioxide, magnesium stearate.

Pharmacological properties

Pharmacodynamics

Cardilopin is an antihypertensive drug with an antianginal effect. Its active substance, amlodipine, is a slow calcium channel blocker (calcium antagonist), inhibits the incoming transmembrane flow of calcium ions into the smooth muscle cells of the vessels and heart. The direct relaxing effect of amlodipine on vascular smooth muscle cells helps to reduce the resistance of peripheral vessels and provides the drug with a hypotensive effect.

The antianginal effect of Cardilopin is a consequence of the expansion of peripheral arterioles and a decrease in OPSS (total peripheral vascular resistance), as a result of which energy and oxygen consumption by the myocardium decreases, and the load on the heart decreases. Dilation of large coronary arteries and arterioles increases the supply of oxygen to normal and ischemic areas of the myocardium.

Amlodipine does not cause reflex tachycardia, the oxygen supply to the myocardium improves, including with spasm of the coronary arteries (unstable angina pectoris, Prinzmetal's angina).

Taking amlodipine 1 time per day with arterial hypertension provides a decrease in blood pressure (BP) in the supine and standing position, which remains clinically stable for 24 hours. Due to the gradual slow vasodilation, the development of acute arterial hypotension while taking Cardilopin is unlikely.

In patients with angina pectoris, taking the drug once a day increases the total time for performing possible physical activity before the development of an angina attack and the time until a significant decrease in the ST interval. In addition, the frequency of angina attacks and the need for nitroglycerin are reduced.

Amlodipine does not adversely affect metabolism, does not affect plasma lipid levels, serum uric acid levels and blood glucose concentrations.

The results of the study showed that taking amlodipine in stage II – III heart failure according to the NYHA classification (New York Heart Association) does not cause worsening of clinical symptoms, does not decrease exercise tolerance and left ventricular ejection fraction in patients. In NYHA stage III – IV heart failure, there was no increase in the incidence of cardiovascular disorders or mortality when combined with diuretics, ACE inhibitors (angiotensin converting enzyme) or digoxin.

The use of Cardilopin in patients with bronchial asthma is shown.

Pharmacokinetics

After oral administration, amlodipine is well absorbed in the gastrointestinal tract (GIT). The maximum concentration in blood plasma is reached after 6-12 hours, simultaneous food intake does not affect the rate and degree of absorption. The absolute bioavailability of amlodipine is 64–80%. The concentration-time curve in blood plasma is biphasic.

The apparent volume of distribution is 21 l / kg. The equilibrium concentration in blood plasma at the level of 5-15 ng / ml is achieved 7-8 days after the start of treatment. Plasma protein binding - 93–98%.

As a result of intensive metabolism in the liver, 90% of the dose of amlodipine taken is converted into inactive pyridine derivatives.

About 10% of the drug is excreted in the urine unchanged. Inactive metabolites are excreted through the kidneys (approximately 60%) and intestines (20-25%). The final half-life is 35-50 hours. The clearance of amlodipine is 7 ml / min / kg, in elderly patients this indicator decreases.

In renal failure or in old age, the pharmacokinetics of amlodipine does not change.

In hepatic insufficiency, the clearance of the active substance is reduced, therefore it is recommended to prescribe lower initial doses.

Indications for use

The use of Cardilopin is indicated as monotherapy or as part of complex therapy in combination with other antianginal agents in the treatment of the following diseases:

• arterial hypertension;
• stable angina, Prinzmetal's angina.

Contraindications

Absolute:

• severe form of arterial hypotension;
• unstable angina (except for Prinzmetal's angina);
• clinically significant aortic stenosis;
• period of pregnancy;
• breast-feeding;
• age up to 18 years;
• hypersensitivity to the components of the drug.

With caution, it is recommended to take Cardilopin tablets for mild or moderate arterial hypotension, sick sinus syndrome (tachycardia, severe bradycardia), hypertrophic obstructive cardiomyopathy, aortic stenosis, mitral stenosis, myocardial infarction (including the acute phase and the period over the next 30 days), dysfunction of the liver, diabetes mellitus, in the stage of decompensation of chronic heart failure, old age.

Cardilopin, instructions for use: method and dosage

Cardilopin tablets are taken orally, once a day, preferably always at the same time.

Recommended dosage: initial dose - 5 mg. To achieve the desired clinical result and taking into account the response to the drug, it is possible to increase the dose to 10 mg.

The maximum daily dose is 10 mg.

With the simultaneous administration of thiazide diuretics, ACE blockers or beta-blockers, the dose of Cardilopin is not changed.

No dose adjustment is required for elderly patients or with renal insufficiency.

In case of impaired liver function, the daily dose of Cardilopin should not exceed 2.5 mg.

Side effects

• from the nervous system: drowsiness, excessive fatigue, mood changes, headache, dizziness, convulsions; rarely - malaise, insomnia, unusual dreams, hypesthesia, paresthesia, asthenia, nervousness, anxiety, depression, tremor, loss of consciousness; very rarely - apathy, agitation, ataxia, parosmia, amnesia;
• on the part of the cardiovascular system: flushing of the face, palpitations, shortness of breath, swelling of the ankles and feet; rarely - excessive decrease in blood pressure, chest pain, rhythm disturbances (ventricular tachycardia, bradycardia, atrial flutter), orthostatic hypotension; very rarely - migraine, heart failure (appearance or aggravation), extrasystole;
• from the digestive system: abdominal pain, nausea; rarely - dry mouth, gingival hyperplasia, vomiting, constipation, diarrhea, anorexia, dyspepsia, flatulence, jaundice, increased activity of hepatic transaminases, hyperbilirubinemia; very rarely - taste perversion, increased appetite, gastritis, pancreatitis;
• from the genitourinary system: rarely - painful urge to urinate, pollakiuria, nocturia, decreased potency and other violations of sexual function; very rarely - polyuria, dysuria;
• from the respiratory system: rarely - dyspnea; very rarely - rhinitis, cough;
• on the part of the musculoskeletal system: rarely - arthrosis, arthralgia, myalgia (with prolonged use), back pain; very rarely - myasthenia gravis;
• from the senses: rarely - visual impairment, pain in the eyes, diplopia, conjunctivitis, xerophthalmia, violation of accommodation, ringing in the ears; very rarely - parosmia;
• allergic reactions: pruritus, rash (including urticaria, erythematous and maculopapular rash);
• dermatological reactions: very rarely - purpura, xeroderma, dermatitis, alopecia;
• others: rarely - a feeling of heat, nosebleeds, chills, weight gain, thirst, increased sweating, gynecomastia; very rarely - hyperglycemia, cold clammy sweat.

Overdose

Symptoms: marked lowering of blood pressure, excessive peripheral vasodilation, tachycardia.

Treatment: immediate gastric lavage, intake of activated charcoal, followed by intensive symptomatic therapy. It is necessary to lay the patient on a flat surface, raising his legs. It is important to ensure careful monitoring of the indicators of heart and lung function, the implementation of urgent measures to maintain the function of the cardiovascular system, control of circulating blood volume and urine output. Perhaps the appointment of vasoconstrictor agents (in the absence of contraindications to their use) in order to restore vascular tone. To eliminate the consequences of calcium channel blockade, intravenous administration of calcium gluconate is indicated.

Hemodialysis is ineffective.

special instructions

Amlodipine has no effect on plasma potassium, glucose, triglycerides, uric acid, LDL (low density lipoprotein), total cholesterol, uric acid nitrogen, creatinine.

Maintaining dental hygiene and regular visits to the dentist can reduce the risk of gum pain, bleeding, or hyperplasia.

Cancellation of Cardilopin must be done by gradually decreasing the dose.

Influence on the ability to drive vehicles and complex mechanisms

The negative effect of amlodipine on the patient's ability to drive vehicles or work with complex mechanisms has not been established. However, given the possibility of drowsiness and dizziness during the use of Cardilopin, it is recommended to observe special precautions when performing work requiring an increased speed of psychomotor reactions and attention.

Application during pregnancy and lactation

The use of Cardilopin during pregnancy is contraindicated (unless the therapeutic effect justifies the possible negative effect of amlodipine on fetal development).

Women of reproductive age are advised to use reliable contraceptive methods to avoid conception during drug treatment.

Do not take Cardilopin during lactation. If necessary, due to the lack of the possibility of using other antihypertensive drugs, breastfeeding is recommended to stop.

Pediatric use

The use of Cardilopin for the treatment of patients under the age of 18 is contraindicated.

With impaired renal function

No dose adjustment is required in patients with renal impairment.

For violations of liver function

Cardilopin should be used with caution in patients with impaired liver function. The daily dose in this category of patients should not exceed 2.5 mg.

Use in the elderly

Elderly patients do not need dose adjustment, but increase the dose of Cardilopin should be done with caution and under close medical supervision.

Drug interactions

• verapamil, diuretics (thiazide and "loop"), beta-blockers, nitrates, ACE inhibitors: enhance the antianginal and hypotensive effect of Cardilopin;
• amiodarone, quinidine, alpha ₁ -adrenergic blockers, antipsychotics, blockers of slow calcium channels: may increase the hypotensive effect of amlodipine;
• calcium preparations: help to reduce the therapeutic effect of slow calcium channel blockers;
• drugs that are inhibitors of microsomal oxidation: due to an increase in the concentration of amlodipine in the blood plasma while taking inhibitors of microsomal oxidation, the risk of developing adverse events increases;
• inducers of liver microsomal enzymes: help to reduce the level of the active substance in the blood plasma;
• indomethacin and other non-steroidal anti-inflammatory drugs (NSAIDs), sympathomimetics, alpha-adrenergic agonists, estrogens: cause a weakening of the hypotensive effect of Cardilopin;
• drugs that affect the lengthening of the QT interval (including procainamide, quinidine): enhancing the negative inotropic effect, these drugs can cause a significant lengthening of the QT interval;
• cimetidine: the pharmacokinetics of amlodipine is not impaired while taking cimetidine;
• digoxin, warfarin: the pharmacokinetic parameters of these drugs are not violated;
• grapefruit juice: drinking grapefruit juice may cause some increase in serum amlodipine concentration, which does not significantly affect the change in blood pressure.

Perhaps the appointment of beta-blockers, thiazide diuretics, nitroglycerin, long-acting nitrates, NSAIDs, antibiotics, oral hypoglycemic drugs in combination with Cardilopin.

Analogs

Analogues of Cardilopin are: Amlodipine, Amlodipine Zentiva, Amlodipine Alkaloid, Amlodipine Sandoz, Amlodipine-Agio, Amlodipine-Biocom, Amlodipine-Borimed, Amlodipine-ZT, Amlodipine-Prana, Amlodipine-Teva, Amlovas, Amlodoprus, Amlodipine, Amlodipine, Amlong, Amlonorm, Kalchek, Kordi Cor, Karmagip, Corvadil, Norvask, Normodipin, Stamlo M, etc.

Terms and conditions of storage

Keep out of the reach of children.

Store at a temperature of 15-25 ° C in a dark place.

The shelf life is 5 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Cardilopin

There are no reviews of Cardilopin either from patients or doctors.

Price for Cardilopin in pharmacies

The price of Cardilopin for a package containing 30 tablets at a dose of 10 mg can be from 574 rubles, at a dose of 5 mg - from 339 rubles.

Cardilopin: prices in online pharmacies

Drug name Price Pharmacy

Cardilopin 5 mg tablets 30 pcs. 266 r Buy

Cardilopin tablets 5mg 30 pcs. 308 RUB Buy

Cardilopin 10 mg tablets 30 pcs. 421 r Buy

Cardilopin 10mg tablets 30 pcs. RUB 609 Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!