Candizol - Instructions For Use, Price, Tablets, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Candizol

Candizol: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. For violations of liver function
12. 12. Drug interactions
13. 13. Analogs
14. 14. Terms and conditions of storage
15. 15. Terms of dispensing from pharmacies
16. 16. Reviews
17. 17. Price in pharmacies

Latin name: Candizole

ATX code: D01AC01

Active ingredient: clotrimazole (Clotrimazole)

Producer: Micro Labs Limited (India)

Description and photo update: 2019-12-07

Candizol is an antifungal drug for external and local use.

Release form and composition

The drug is produced in the following dosage forms:

• vaginal tablets: white, 100 mg - torpedo-shaped, 200 and 500 mg - oblong, with a line on one side (6 or 10 pcs. in an aluminum strip, in a cardboard box 1 strip complete with an applicator and instructions for use);
• cream for external use: white, homogeneous, free from foreign inclusions (20 g each in an aluminum tube, in a cardboard box 1 tube and instructions for use of Candizol).

1 vaginal tablet contains:

• active substance: clotrimazole - 100, 200 or 500 mg;
• additional components: corn starch, microcrystalline cellulose (200 mg), lactose, croscarmellose sodium (100 and 500 mg), propyl parahydroxybenzoate, magnesium stearate, methyl parahydroxybenzoate, talc, colloidal silicon dioxide.

1 g of cream contains:

• active substance: clotrimazole - 10 mg;
• additional components: white soft paraffin, benzyl alcohol, sorbitan monostearate, liquid paraffin, propylene glycol, cetostearyl alcohol, cetomacrogol 1000, purified water.

Pharmacological properties

Pharmacodynamics

Clotrimazole, the active ingredient of Candizol, is an antifungal agent used externally and intravaginally, belonging to the group of imidazole derivatives. It reduces the production of ergosterol, which is an integral part of the fungal cell membrane, which causes a change in the permeability of the plasmalemma and causes further cell lysis.

In small concentrations, the active substance exhibits a fungistatic effect, and in high concentrations (more than 20 μg / ml) it is fungicidal, affecting not only proliferating cells. When used in fungicidal concentrations, clotrimazole interacts with peroxidase and mitochondrial enzymes, resulting in an increase in the content of hydrogen peroxide to a toxic level, which in turn also contributes to the destruction of fungal cells.

The drug demonstrates activity against pathogenic dermatophytes (Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis), mold and yeast fungi (the genus Rhodotorula, Pityrosporum orbiculare, the genus Candida, Torulopsis and Malaria versia versicolor) furfur).

Pharmacokinetics

With intravaginal use, the absorption of the active substance is 3-10% of the administered dose. High levels of the drug in vaginal secretions and low levels in the blood are noted for 48-72 hours. In the process of a fairly rapid biotransformation of clotrimazole in the liver, inactive metabolites are formed.

When applied externally, the drug is poorly absorbed through the skin and mucous membranes, and practically does not have a systemic effect. The concentration level of the drug in the epidermis is higher than in the subcutaneous tissue and dermis. In the deep layers of the epidermis, the content of clotrimazole exceeds the minimum inhibitory concentration for dermatophytes.

Indications for use

Vaginal tablets Candizol are recommended for adults and adolescents, after the onset of sexual activity, for the following diseases:

• genital superinfections due to microorganisms susceptible to clotrimazole;
• genital infections caused by yeast-like fungi of the genus Candida.

Cream for external use Candizol is prescribed for the treatment of the following diseases / conditions:

• fungal skin lesions, including mycoses of the feet and skin folds (prevention / treatment);
• mycoses complicated by secondary pyoderma as part of combined treatment;
• fungal lesions of the smooth skin, excited by dermatophytes, molds, yeasts (including the genus Candida) and other varieties of fungi sensitive to clotrimazole;
• pityriasis versicolor versicolor.

Contraindications

Absolute:

• I trimester of pregnancy;
• menstrual period (for tablets);
• hypersensitivity to any of the constituents of the antifungal agent.

Caution is required to use Candizol during breastfeeding.

Candizol, instructions for use: method and dosage

Vaginal pills

Candizol tablets are used intravaginally.

Adults and adolescents are recommended to inject the drug as deep as possible into the vagina while lying on the back with slightly bent legs.

Recommended dosage regimen: 1 tablet daily in the evening before bedtime. The duration of treatment depends on the dosage: 100 mg tablets are taken for 6 days; 200 mg tablets - 3 days, 500 mg tablets - once.

After consulting a specialist, a second course is possible.

Cream for external use

Candizol cream is used externally.

For adults and children, the drug should be applied 2-3 times a day to previously cleaned and dried problem areas of the skin with a thin layer, then gently rub in.

The course of therapy depends on the severity of the lesion, the localization of the disease and the effectiveness of Candizol. Therapy for dermatomycosis is carried out for at least 28 days, for pityriasis versicolor - for at least 21 days. In case of fungal infections of the feet, it is recommended to continue treatment for at least 14 days after the symptoms of the disease have subsided.

Side effects

When using vaginal tablets, the following undesirable effects may appear: vaginal discharge, burning, itching and swelling of the vaginal mucosa, frequent urination, pain during intercourse, intercurrent cystitis, gastralgia, headache, skin allergic reactions, burning sensation in the penis in a sexual partner …

In the case of using the cream, there may be side effects such as tingling and burning at the sites of application of the drug, peeling and irritation of the skin, blisters, edema, erythema, allergic reactions in the form of itching, urticaria.

Overdose

There is practically no threat of an overdose of vaginal tablets, since the antifungal agent acts locally. In case of accidental oral administration of tablets, the following symptoms may occur: nausea, anorexia, gastralgia, vomiting, impaired liver function; rarely - pollakiuria, drowsiness, hallucinations. There is no specific antidote. If an overdose is suspected, activated carbon is prescribed and symptomatic treatment is carried out, if necessary.

The use of the cream in higher doses does not lead to any reactions and life-threatening conditions.

special instructions

In case of a simultaneous infection of the labia and adjacent areas (candidal vulvitis), it is recommended to additionally use Candizol in the form of a cream against the background of treatment with vaginal tablets.

In order to prevent urogenital reinfection, simultaneous therapy of sexual partners is necessary.

Candizol cream is not recommended to be applied to the skin around the eyes.

Do not treat areas of ulcers, erosions, wound surfaces with the drug, as well as areas with other violations of the integrity of the skin.

It is required to stop Candizol therapy if signs of irritation or hypersensitivity occur.

If the desired effect cannot be achieved within 3 weeks of using the tablets or 4 weeks of using the cream, you should contact your doctor to verify the diagnosis.

Application during pregnancy and lactation

In the first trimester of pregnancy, the use of Candizol is contraindicated.

In the II and III trimesters of pregnancy, as well as during breastfeeding, vaginal tablets can be used only if the expected benefit for the woman significantly exceeds the potential threat to the health of the fetus / child. In pregnant women, therapy with vaginal tablets should be performed without an applicator.

In the course of clinical and experimental studies during pregnancy or lactation, no negative effects of the drug in the form of a cream on the health of the mother or fetus / child have been revealed. However, the appropriateness of using the cream in pregnant and lactating women should be determined individually by the attending physician. It is contraindicated to apply the agent directly to the lactating breast.

Pediatric use

Candizol vaginal tablets are recommended for adolescents (after the onset of sexual activity) according to indications.

Cream treatment can be carried out in children according to the indications.

For violations of liver function

In the presence of liver failure, it is required to periodically monitor the functional state of the liver.

Drug interactions

With the combined use of vaginal tablets Candizol with other drugs, the following pharmacological interaction is possible:

• amphotericin B and other polyene antibiotics: vaginal administration of clotrimazole decreases the activity of these drugs;
• nystatin / natamycin: reduce the effect of clotrimazole.

When using Candizol in the form of a cream, negative interactions with other drugs / agents have not been established and are not expected, since clotrimazole has an extremely low absorption capacity.

Analogs

Candid, Candibene, Clotrimazole, Candid-B6, Kanesten, Clotrimazole-Akrihin, Kanizon, Clotrimazole-Teva, etc. are analogs of Candidizol.

Terms and conditions of storage

Store in a place protected from moisture and light, out of the reach of children, at a temperature not exceeding 25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Kandizol

The few reviews about Candizol that are found on medical sites are mostly positive. Patients note that the drug in the form of a cream effectively helps to cope with fungal skin lesions, including mycoses of the feet, as well as pityriasis versicolor. After 2-3 weeks of therapy, itching and peeling are relieved, cracks in the feet are healed. Relapses of the disease are not recorded.

Vaginal tablets, according to women who have used Candizol, successfully relieve itching, burning and other symptoms of thrush, without causing discomfort and other unpleasant sensations.

The price of Candizol in pharmacies

There is no reliable information on the price of Candizol, since the drug is currently not available in the pharmacy chain.

The cost of Clotrimazole, an analogue of Candizol for the active ingredient, can be:

• vaginal tablets (100 mg) per pack containing 6 pcs. - 15–45 rubles;
• cream for external use for a tube containing 20 g - 50–150 rubles.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!