Triazavirin - Instructions For Use, Price, Reviews, Capsule Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Triazavirin

Triazavirin: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Triazavirin

ATX code: J05AX

Active ingredient: sodium methylthionitrooxodihydrotriazolotriazinide sodium methylthionitrooxodihydrotriazolotriazinide

Manufacturer: Plant Medsintez, LLC (Russia)

Description and photo updated: 2018-23-11

Prices in pharmacies: from 1027 rubles.

Buy

Triazavirin is a direct antiviral drug (not a symptomatic agent and not an immunomodulator); effective against influenza viruses, including avian and swine, as well as ARVI (acute respiratory viral infections) of any etiology; is active at any stage of the disease, and not only at the beginning of infection.

Release form and composition

Triazavirin is available in the form of capsules: size No. 1, hard gelatinous, red cap and yellow body, inside capsules - granules or fine crystalline powder of yellow-green or yellow color (10 pcs. In blisters, in a cardboard box 2 or 5 packs; 20 or 50 pcs. in orange glass jars or polymer jars, in a cardboard box 1 jar or jar).

1 capsule contains:

• active substance: sodium methylthionitrooxodihydrotriazolotriazinide dihydrate (triazavirin) - 250 mg;
• auxiliary component of the capsule contents: calcium stearate;
• capsule body: titanium dioxide (E171), medical gelatin, dyes - sunset yellow (E110), quinoline yellow (E104);
• capsule cap: titanium dioxide (E171), medical gelatin, azorubin (E122).

Pharmacological properties

Pharmacodynamics

Triazavirin is a synthetic analogue of the bases of purine nucleosides (guanine), which have a pronounced antiviral activity against RNA viruses. The mechanism of action of the drug is mainly due to inhibition of the synthesis of viral RNA (ribonucleic acid) and the replication of genomic fragments.

Pharmacokinetics

After oral administration, the active substance is rapidly absorbed in the gastrointestinal tract. The maximum concentration (C _max) of triazavirin in blood plasma is reached after 1–1.5 hours and averages 0.0048 mg / ml when taken in a dose of 250 mg 3 times a day.

T _1/2 (half-life) is 1-1.5 hours. Through the kidneys, 15–45% of triazavirin is excreted unchanged. The calculated clearance averages 246 ml / min.

Indications for use

According to the instructions, Triazavirin is indicated for the treatment of influenza in adult patients, including in combination with symptomatic drugs.

Contraindications

• renal failure;
• liver failure;
• period of pregnancy;
• breast-feeding;
• age up to 18 years;
• hypersensitivity to the components of the drug.

Instructions for the use of Triazavirin: method and dosage

Triazavirin capsules are taken orally, regardless of food intake.

Recommended dosage: 1 pc. 3 times a day, the duration of the course of treatment is 5-7 days.

It is necessary to start using the drug after the onset of clinical symptoms of influenza within the first two days.

Side effects

• from the immune system: allergic reactions;
• from the digestive system: nausea, vomiting, flatulence, diarrhea.

Overdose

Overdose symptoms are stomach pain, nausea, vomiting, dyspepsia.

It is recommended to carry out symptomatic therapy, if necessary, to cancel the drug.

special instructions

If any undesirable phenomena occur, you should consult a doctor.

Application during pregnancy and lactation

The use of Triazavirin during gestation and lactation is contraindicated due to the lack of information on the safety and effectiveness of therapy.

If necessary, taking capsules during lactation, breastfeeding should be temporarily stopped.

Pediatric use

The appointment of the drug for the treatment of children and adolescents under the age of 18 is contraindicated.

With impaired renal function

The use of Triazavirin in patients with renal failure is contraindicated.

For violations of liver function

The use of the drug in patients with hepatic insufficiency is contraindicated.

Drug interactions

Simultaneous use with analogues of purine and pyrimidine bases increases the toxicity of the drug.

If necessary, the combination with ribavirin requires a decrease in the usual dose of the latter.

Analogs

Analogs of Triazavirin are Virazol, Viferon, Oxolin, Acyclovir, Zovirax, Tebrofen, Gerpevir, Grippferon, Hyporamine ointment, Ribavirin, Rimantadin.

Terms and conditions of storage

Keep out of the reach of children.

Store at temperatures up to 25 ° C, protected from moisture and light.

The shelf life is 5 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Triazavirin

In reviews of Triazavirin, patients give a positive assessment of the effectiveness of the drug in the treatment of influenza. They indicate that the use of an antiviral drug from the first days of the disease leads to a full recovery within 5 days and avoids the characteristic severe complications that often occur with influenza. In the case of a timely start of treatment, the disease proceeds with less pronounced symptoms and is not accompanied by a very high body temperature. The capsules are advised to be swallowed whole, as their contents have a very bitter taste.

Price for Triazavirin in pharmacies

The price of Triazavirin for a package containing 20 capsules can range from 946 rubles.

Triazavirin: prices in online pharmacies

Drug name Price Pharmacy

Triazavirin 250 mg capsules 20 pcs. 1027 RUB Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!