Calcium Gluconate-SOLOfarm - Instructions For The Use Of Injections, Reviews

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Calcium Gluconate-SOLOfarm - Instructions For The Use Of Injections, Reviews
Calcium Gluconate-SOLOfarm - Instructions For The Use Of Injections, Reviews

Video: Calcium Gluconate-SOLOfarm - Instructions For The Use Of Injections, Reviews

Video: Calcium Gluconate-SOLOfarm - Instructions For The Use Of Injections, Reviews

Calcium gluconate-SOLOpharm

Latin name: Calcium gluconate-SOLOpharm

ATX code: А12АА03

Active ingredient: calcium gluconate (Calcium gluconate)

Manufacturer: LLC "Grotex" (Russia)

Description and photo update: 2020-28-07

Prices in pharmacies: from 102 rubles.


Solution for intravenous and intramuscular administration of Calcium gluconate-SOLOpharm
Solution for intravenous and intramuscular administration of Calcium gluconate-SOLOpharm

Calcium gluconate-SOLOpharm is a regulator of calcium-phosphorus metabolism, which compensates for the lack of calcium in the body.

Release form and composition

Dosage form - solution for intravenous (i / v) and intramuscular (i / m) administration: colorless or slightly colored (with a brownish tint) liquid [5 or 10 ml in polymeric ampoules Politvist (made of low density polyethylene / polypropylene), equipped with a twisting cap for taking a solution with a syringe without a needle, in a cardboard box of 10 polymer ampoules and instructions for the use of Calcium gluconate-SOLOpharm; 5 or 10 ml in ampoules of colorless / colored glass, 5 ampoules of glass in a blister / cardboard box with cells for ampoules, in a cardboard box, 2 packages / forms of cardboard with or without ampoule scarifier and instructions for use of the drug].

Composition for 1 ml of solution:

  • active substance: calcium gluconate monohydrate - 94 mg;
  • auxiliary ingredients: calcium saccharate - 5 mg, water for injection - up to 1 ml.

Pharmacological properties


Calcium gluconate-SOLOpharm is a calcium preparation that compensates for the deficiency of calcium ions, which are necessary for synaptic transmission of nerve impulses, contraction of skeletal and smooth muscles, cardiac muscle function, blood coagulation, osteogenesis (the process of bone tissue formation).

When administered intravenously, the drug stimulates the sympathetic part of the autonomic nervous system, increases the synthesis of adrenaline by the adrenal glands.


Parenteral administration of calcium gluconate ensures an even distribution of the substance with the blood flow in all tissues and organs. Calcium in blood plasma is found both in bound form, in a complex with proteins and anions of organic / inorganic acids (bicarbonate, lactate, calcium citrate, phosphate), and in the form of free ions.

Calcium passes through the placental barrier, penetrates into breast milk during lactation.

It is excreted from the body mainly by the kidneys.

Indications for use

Calcium gluconate-SOLOpharm is used for the treatment of acute hypocalcemia.

The drug is also used to reduce capillary permeability associated with allergic conditions, non-thrombocytopenic purpura and exudative dermatoses, for example, with dermatitis herpetiformis and maculopapular rash due to drug allergies.



  • hypercalciuria;
  • hypercalcemia, including in patients with hypervitaminosis D, hyperparathyroidism, renal failure, decalcifying malignant neoplasms, sarcoidosis, osteoporosis due to immobilization, Burnett's syndrome (lactic-alkaline syndrome);
  • poisoning with cardiac glycosides;
  • use simultaneously with therapy with cardiac glycosides;
  • children's age - for intramuscular injection;
  • hypersensitivity to calcium gluconate and auxiliary components of the drug.

With caution, after consultation with a specialist, Calcium gluconate-SOLOpharm is used in patients with dehydration, electrolyte disturbances (hypercalcemia may develop), diarrhea, malabsorption syndrome, a history of calcium nephrourolithiasis, minor hypercalciuria, moderate hyperosclerosis, chronic renal atherosclerosis, in old age (especially in the presence of one or more of the conditions listed above), with nephrocalcinosis, pathology of the cardiovascular system, sarcoidosis, chronic heart failure, the simultaneous use of epinephrine.

Calcium gluconate-SOLOpharm, instructions for use: method and dosage

Calcium gluconate-SOLOpharm solution is intended for parenteral administration by intravenous or intramuscular administration. Calcium-containing solutions must be injected slowly to minimize peripheral vasodilation and cardiac depression. Before administration, the drug should be heated to body temperature.

The rate of total calcium in the blood serum is 2.25-2.75 mmol / l (4.45-5.5 sEq / l). The introduction of calcium gluconate is intended to ensure the restoration of normal levels of calcium in the blood plasma.

Recommended dosage of Calcium gluconate-SOLOpharm for adult patients: the solution is injected deeply intramuscularly, slowly intravenously (for 2-3 minutes) or intravenously drip in a dose of 5-10 ml 100 mg / ml (10% solution), daily, every other day or once every two days (taking into account the clinical condition of the patient and the nature of the disease). Subsequent dosing is determined by taking into account the serum calcium concentration in the blood.

For children and adolescents under 18 years of age, the dose and route of administration is prescribed depending on the level of development of hypocalcemia, as well as the nature and severity of symptoms.

Recommended dosage of Calcium gluconate-SOLOpharm for children, depending on age [10% solution (100 mg / ml) is injected intravenously]:

  • up to 6 months - 0.1-1 ml;
  • from 7 to 12 months - 1-1.5 ml;
  • from 1 to 3 years - 1.5–2 ml;
  • from 4 to 6 years old - 2–2.5 ml;
  • from 7 to 14 years old - 3.5 ml;
  • over 14 years old - dosage as for adults.

It is forbidden for children to injections of Calcium gluconate-SOLOpharm into the muscle, as this can lead to the development of necrosis. It is recommended to carry out a slow intravenous injection or intravenous infusion after dilution of the solution (to reduce the rate of administration and exclude the development of local irritation or necrosis due to its accidental ingress into the perivascular tissues).

For intravenous infusion, the solution is diluted in a ratio of 1 ÷ 10, providing a concentration of 10 mg / ml, using 0.9% sodium chloride solution or 5% glucose solution. Dilution is required under aseptic conditions. The rate of intravenous infusion should not exceed 50 mg of calcium gluconate per minute.

Sequence of work with a polymer ampoule:

  1. Take the ampoule, holding the neck, and shake it.
  2. Slide the valve with a twisting motion and separate.
  3. Immediately insert the tip-cone of the syringe into the opened hole of the ampoule.
  4. Take the solution from the ampoule into the syringe.
  5. Put a needle on the syringe.

Side effects

The incidence of adverse reactions directly depends on the rate of administration of the solution and the dose of calcium. Subject to the rules of introduction, this figure does not exceed 1/1000.

Possible negative effects on the part of systems and organs when using Calcium gluconate-SOLOfarm:

  • digestive system: nausea, vomiting, diarrhea;
  • cardiovascular system: lowering blood pressure, vasodilation, arrhythmia, bradycardia, circulatory collapse (including fatal), flushing, in most cases due to rapid administration;
  • general disorders: sweating, feeling of warmth;
  • disturbances at the site of intramuscular injection: pain or erythema (with a frequency of 1/10 to 1/100); in case of violation of the technique of intramuscular injection - infiltration into the lipid tissue with the subsequent formation of an abscess, tissue compaction and necrosis;
  • Violations at the intravenous injection site: skin hyperemia, burning sensation or pain with the possible development of tissue necrosis in the case of administration of Calcium gluconate-SOLOpharm into the perivascular space. There were reports of soft tissue calcification and subsequent skin lesions with the possible development of necrosis due to the release of calcium from the vessel into the tissue.


Symptoms of calcium overdose (hypercalcemia) are anorexia, abdominal pain, nausea, vomiting, constipation, dehydration, polyuria, polydipsia, bone pain, muscle weakness, kidney calcification, confusion, drowsiness, hypersomnia, increased blood pressure; with severe intoxication, arrhythmia (up to cardiac arrest) and coma are possible.

Therapy of the condition is aimed at reducing the elevated level of calcium in the blood plasma. At the initial stage, rehydration is carried out. In the case of severe hypercalcemia, in order to increase the amount of extracellular fluid, intravenous infusion of 0.9% sodium chloride solution may be required. Calcitonin is recommended to reduce calcium concentration. If it is necessary to accelerate the excretion of calcium, you can apply Furosemide. However, thiazide diuretics cannot be used, since they can enhance the absorption of calcium salt in the kidneys. Treatment of hypercalcemia is followed by careful monitoring of serum electrolyte concentrations in the blood.

Hemo- or peritoneal dialysis should be performed when other measures have proved ineffective or symptoms of hypercalcemia persist.

special instructions

Calcium gluconate-SOLOpharm is injected deeply in / m, slowly in / in (within 2-3 minutes) or in / in drip.

It is preferable to inject the solution into a vein in order to exclude local irritation or necrosis that develops when it enters the perivascular tissues. IV injections are carried out under close monitoring of heart rate (heart rate) and ECG (electrocardiogram), since too rapid administration of calcium gluconate can cause bradycardia with vasodilation and arrhythmia.

During the intravenous administration of calcium gluconate, the patient may experience a rapidly passing sensation of heat throughout the body.

Due to the likelihood of local irritation, intramuscular injections of Calcium gluconate-SOLOpharm are done only if it is impossible to administer the drug intravenously. The IM solution is injected deep enough into the muscle, mainly in the gluteal region. For overweight patients, the injection is given with a longer needle to safely reach the muscle tissue through the fatty deposits. Each time with repeated injections, the injection site is changed.

During therapy, careful monitoring of the calcium content in the blood plasma is provided, and with the introduction of high doses, the rate of renal elimination of calcium in the urine is additionally controlled.

In / in the introduction of calcium gluconate to patients receiving cardiac glycosides, in exceptional cases, it may require monitoring of cardiac activity and providing conditions for urgent treatment of such complications from the heart as severe arrhythmias.

Calcium salts are used with caution and only after careful establishment of indications in the treatment of patients with pathologies of cardiovascular function, nephrocalcinosis, sarcoidosis (Beck's disease), with the simultaneous use of epinephrine and in elderly patients.

Since impaired renal function may be associated with secondary hyperparathyroidism and hypercalcemia, parenteral calcium administration is prescribed for patients in this group only after a thorough medical examination, always under the control of calcium-phosphate balance.

In case of simultaneous use of other medicinal products with Calcium gluconate-SOLOpharm solution, specialist supervision is required.

The solution is allowed for use, provided that the ampoule is completely transparent and intact.

Dilute Calcium gluconate-SOLOfarm immediately after opening the ampoule, strictly observing the rules of asepsis.

The ampoule is for single use only. From the point of view of microbiological safety, the prepared solution should be injected immediately. A possible exception is dilutions performed under controlled aseptic conditions. In this case, the terms and conditions of storage of the prepared solution prior to administration are the responsibility of the patient. The shelf life should not exceed 24 hours, the temperature range is 2–8 ° С. The remaining unused solution must be disposed of.

Influence on the ability to drive vehicles and complex mechanisms

During therapy with a solution of Calcium gluconate-SOLOpharm, it is important to be careful when performing potentially hazardous types of work that require increased concentration of attention and high speed of psychomotor reactions (for example, when driving vehicles, working with driving mechanisms, performing the functions of a dispatcher or operator).

Application during pregnancy and lactation

Calcium crosses the placental barrier and passes into breast milk.

Due to the fact that hypercalcemia negatively affects the fetus / child, the use of Calcium gluconate-SOLOfarm for the treatment of pregnant and breastfeeding women is allowed only if the concentration of calcium in the blood serum is carefully monitored.

Pediatric use

In pediatric practice, intramuscular administration of a solution of Calcium gluconate-SOLOpharm to children is contraindicated due to the possible development of necrosis.

With impaired renal function

Calcium gluconate-SOLOpharm is used with caution in patients with moderate chronic renal failure, with nephrocalcinosis and in the case of a history of calcium nephrourolithiasis.

The appointment of calcium gluconate in hypercalcemia in patients with renal failure is contraindicated.

For violations of liver function

Liver dysfunction does not affect drug therapy.

Use in the elderly

Calcium salts are used with caution, only after careful establishment of indications, in the treatment of elderly patients.

There is no information about the unfavorable tolerance of calcium gluconate in elderly patients, but age-related changes such as impaired renal function and slowed metabolism may require dose reduction.

Drug interactions

The syringe filled with a calcium gluconate solution should not contain residues of ethyl alcohol, since in its presence calcium precipitates.

Pharmaceutical interaction of Calcium gluconate-SOLOpharm with medicinal substances / preparations used simultaneously:

  • carbonates, salicylates, sulfates, ceftriaxone: incompatible with calcium gluconate solution, since they form insoluble or hardly soluble calcium salts with it;
  • antibiotics of the tetracycline series: their antibacterial effect decreases due to the possible formation of insoluble complexes with calcium gluconate;
  • BMCC (slow calcium channel blockers): calcium gluconate weakens their effect, for example, its intravenous administration before or after taking verapamil reduces the hypotensive effect of the latter, but has little effect on antiarrhythmic efficacy;
  • quinidine: calcium gluconate is able to slow down its intraventricular conduction and increase toxicity;
  • cardiac glycosides: it is not recommended to use simultaneously with calcium, because it can potentiate their cardiotoxic effect;
  • thiazide diuretics: can increase hypercalcemia;
  • calcitonin: in the treatment of hypercalcemia, its effectiveness decreases;
  • phenytoin: its bioavailability decreases.


Analogues of Calcium gluconate-SOLOpharm are Aquadetrim, Alphadol-Ca, Vitrum Osteomag, Dihydrotachysterol, Zemplar, Calcemin, Calcemin Advance, Calcium D3 Actavis, Calcium D3 classic, Calcium Sandoz Forte, Calcium-D3 Nycomed, Calcium-D3 -MIK, Calcium + Vitamin C, Calcium glycerophosphate, Calcium gluconate, Calcium chloride, Osteogenon, Fortedetrim, etc.

Terms and conditions of storage

Store at a temperature not exceeding +25 ° С. Keep out of the reach of children.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Calcium gluconate-SOLOpharm

Calcium gluconate injections are called "hot injections", as part of complex therapy, they improve the patient's condition and accelerate the cure for many diseases. Therefore, most of the reviews about Calcium gluconate-SOLOpharm are positive. They also note the affordable cost of the drug.

In the reviews, patients indicate the need for slow administration of the solution and pay attention to the fact that in each case the reaction to Calcium gluconate-SOLOpharm is individual and unpredictable.

Price for Calcium gluconate-SOLOpharm in pharmacies

The current average price of Calcium gluconate-SOLOpharm, solution for intravenous and intramuscular administration, 100 mg / ml, for 10 ampoules in a package: 5 ml ampoules - 102 rubles; ampoules 10 ml - 193 rubles.

Calcium gluconate-SOLOpharm: prices in online pharmacies

Drug name



Calcium gluconate-SOLOpharm solution for i / v and i / m 100 mg / ml (amp) 5 ml 10 pcs.

102 RUB


Maria Kulkes
Maria Kulkes

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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