Magnesol - Instructions For Use, Reviews, Price, Analogues

2023 Author: Rachel Wainwright | [email protected]. Last modified: 2023-06-01 00:39

Magnesol

Magnesol: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Magnesol

ATX code: А12СС

Active ingredient: solution - magnesium (Magnesium), pyridoxine (vitamin B6) [Pyridoxinum (Vitamin B6)]; tablets - magnesium citrate (Magnesium citrate)

Manufacturer: LLC "Rubicon" (Republic of Belarus)

Description and photo updated: 2018-29-11

Prices in pharmacies: from 799 rubles.

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Magnesol is a mineral food supplement, an additional source of magnesium.

Release form and composition

Release forms:

• oral solution: liquid with a transparent structure from colorless to light yellow, has a caramel smell (20 ml each in amber glass vials, 5 vials in a cardboard box);
• effervescent tablets (20 pcs. in a package).

Each package also contains instructions for the use of Magnesol.

1 bottle of solution contains:

• active ingredients: pyridoxine hydrochloride - 20 mg, magnesium pidolate - 1872 mg, magnesium lactate dihydrate - 372 mg [total magnesium content - 200 mg (8.22 mmol)];
• auxiliary components: saccharin sodium, aromatic additive "Cherry caramel" [vanillin, benzyl alcohol, ethyl vanillin, ethyl acetate, natural citrus oils, aldehyde C16, propylene glycol (E1520), methyl parahydroxybenzoate (methylparaben), caramel color, water (E150d).

In 1 tablet, the content of magnesium citrate is 150 mg.

Pharmacological properties

Pharmacodynamics

Magnesol is a magnesium preparation intended for the prevention and replenishment of magnesium deficiency in the body. Magnesium is an essential mineral found in all tissues and organs, essential for the normal functioning of cells. Half of the total amount of magnesium in the body is found in bone tissue, the rest is in liquid media. Magnesium is predominantly an intracellular cation. It participates in enzymatic and metabolic processes, promotes the production and consumption of energy, reduces the excitability of neurons and neuromuscular transmission of excitation.

The level of magnesium in the blood serum, which is 12-17 mg / l, indicates a moderate deficiency, below 12 mg / l - a pronounced lack of magnesium in the body.

The reason for the lack of magnesium can be both a congenital anomaly of its metabolism, and a limited intake as a result of an unbalanced diet (including malnutrition), alcoholism, complete parenteral nutrition. In addition, a lack of magnesium in the body can be the result of frequent intake of laxatives, significant mental or physical stress, impaired gastrointestinal absorption (hypoparathyroidism, chronic diarrhea, gastrointestinal fistula) or significant losses at the renal level (tubular pathology, polyuria, chronic pyelonephritis, primary hyperaldosteronism, taking diuretics or cisplatin).

The presence of vitamin B ₆ in the solution improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells.

Pharmacokinetics

After ingestion of the solution, absorption of magnesium salts in the gastrointestinal tract occurs through a passive mechanism, in which the solubility of the salt plays a decisive role. The absorption rate does not exceed 50%.

Magnesium is excreted through the kidneys.

Indications for use

The use of Magnesol is indicated for the prevention and correction of the magnesium content in the body. The following symptoms or a combination of them may indicate a deficiency of this element:

• increased fatigue, sleep disturbances, nervousness, irritability, depression, apathy, depression;
• a state of anxiety, accompanied by a rapid heartbeat (in people with a healthy heart) or gastrointestinal cramps;
• cramps of the calf muscles, tingling sensation.

Contraindications

Absolute:

• hypermagnesemia;
• hypersensitivity to the components of Magnesol.

Additional contraindications for oral solution:

• severe renal failure [creatinine clearance (CC) less than 30 ml / min];
• simultaneous use with levodopa.

Magnesol should be used with caution in the form of a solution for oral administration in patients with moderate renal failure (due to the risk associated with hypermagnesemia), ischemic heart disease, gastric ulcer and duodenal ulcer.

Magnesol, instructions for use: method and dosage

Oral solution

Injection use of the solution is strictly prohibited!

Magnesol solution is taken orally, after dissolving the contents of one bottle in 200 ml of drinking water during meals.

Recommended dosage:

• adults: 200 mg (1 bottle) 2 times a day;
• children weighing more than 10 kg: at the rate of 10-30 mg per 1 kg of body weight per day. The daily dose can be taken once or divided into 2 doses.

The duration of the course is 30 days. If necessary, the course can be continued until the blood magnesium level is normalized.

Do not exceed the recommended dosage.

Effervescent tablets

Magnesol tablets are taken orally, after dissolving 1 pc. in 150 ml of water.

The recommended dosage is 2-3 pcs. in a day.

Do not exceed the recommended dosage.

Side effects

Long-term use of Magnesol in high doses can cause diarrhea.

In addition, against the background of an oral solution, the development of allergic and / or skin reactions, abdominal pain is possible.

Overdose

Symptoms: nausea, vomiting, drop in blood pressure, electrocardiogram abnormalities, depression of respiration and central nervous system, decreased reflexes, anuric syndrome, coma, respiratory paralysis, cardiac arrest.

In case of symptoms of an overdose, you should immediately seek medical attention. Rehydration and forced diuresis are indicated as treatment. Patients with renal insufficiency are prescribed hemodialysis or peritoneal dialysis sessions.

special instructions

With a moderate degree of renal failure, magnesium supplements should be taken with caution due to the increased risk of hypermagnesemia.

The amount of sodium in one vial is 23 mg (less than 1 mmol).

It should be borne in mind that in case of hypocalcemia, magnesium deficiency should be replenished before starting calcium supplementation.

For the treatment of severe hypomagnesemia, patients with malabsorption should be prescribed intravenous magnesium preparations.

In severe liver dysfunctions, high doses of pyridoxine can worsen the condition.

Influence on the ability to drive vehicles and complex mechanisms

Magnesol does not affect the patient's ability to drive vehicles and work with complex mechanisms.

Application during pregnancy and lactation

The use of Magnesol during gestation is indicated only as directed by a doctor.

During lactation, the daily dose of pyridoxine for the mother should not exceed 20 mg.

Pediatric use

The recommended dosage of Magnesol in the form of an oral solution for children weighing more than 10 kg: at the rate of 10-30 mg per 1 kg of body weight per day. The daily dose can be taken once or divided into 2 doses. The duration of the course is 30 days.

With impaired renal function

It is contraindicated to use Magnesol in the form of a solution for oral administration in severe renal failure (CC less than 30 ml / min).

With caution, the solution should be taken with a moderate degree of renal failure due to the risk of developing hypermagnesemia.

For violations of liver function

When using the solution for oral administration, it should be borne in mind that with severe liver dysfunction, high doses of pyridoxine can worsen the condition.

Drug interactions

Magnesium:

• calcium, phosphorus salts: inhibit the absorption of magnesium, so they should not be combined with Magnesol;
• oral tetracyclines: there is a decrease in the absorption of tetracyclines in the gastrointestinal tract, so the interval between taking tetracyclines and magnesium should be at least three hours;
• thrombolytic agents for oral administration: weaken their effect;
• iron preparations: their absorption decreases.

Pyridoxine (part of the oral solution):

• levodopa: there is a clinically significant decrease in the effects of levodopa or their complete suppression;
• hormonal contraceptives: increase the concentration of pyridoxine (vitamin B ₆) in the blood plasma;
• diuretics: their action is potentiated;
• penicillamine, cycloserine, isonicotin hydrazide: reduce the effect of pyridoxine;
• phenobarbital, phenytoin: a decrease in the level of concentration of phenobarbital or phenytoin in blood plasma is possible.

Analogs

Analogues of Magnesol are: Ritmokor, Magnefar, Magnikum, Magnerot, Magne B ₆, Magvit B ₆, Panangin, etc.

Terms and conditions of storage

Keep out of the reach of children.

Store at temperatures up to 25 ° C, tablets - in a dry place, solution - in a dark place.

Shelf life: solution - 1.5 years, tablets - look on the package.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Magnesol

There are currently no reviews about Magnesol.

The price of Magnesol in pharmacies

The price of Magnesol for a pack containing 20 tablets can range from 652 rubles.

Magnesol: prices in online pharmacies

Drug name Price Pharmacy

Magnesol B2 7 g granules for preparation of oral solution 30 pcs. RUB 799 Buy

Magnesol B2 granules sachet 7,1g 30 pcs. 823 RUB Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!