Perftoran - Instructions For Use, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Perftoran

Perftoran: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Drug interactions
11. 11. Analogs
12. 12. Terms and conditions of storage
13. 13. Terms of dispensing from pharmacies
14. 14. Reviews
15. 15. Price in pharmacies

Latin name: Perftoranum

ATX code: B05AA03

Active ingredient: Perfluoroorganic compounds

Producer: Perftoran NPF JSC (Russia)

Description and photo updated: 15.08.2018

Perftoran is a blood substitute with a gas transport function.

Release form and composition

Dosage form - an emulsion for intravenous (iv) administration: after thawing - transparent, with a bluish tinge, odorless (50, 100, 200 or 400 ml in glass bottles with rubber caps, crimped with aluminum caps).

100 ml of emulsion contains the following active substances:

• Pfocalin - 13 g;
• Pforidin - 6.5 g;
• Proxanol - 4 g;
• Sodium chloride - 0.6 g;
• Glucose - 0.2 g;
• Sodium bicarbonate - 0.065 g;
• Potassium chloride - 0.039 g;
• Sodium phosphate monobasic - 0.02 g;
• Magnesium chloride (in terms of dry matter) - 0.019 g.

Water for injection (up to 100 ml) is used as an auxiliary substance.

Pharmacological properties

Pharmacodynamics

Perftoran is an oxygen-carrying blood substitute based on perfluoroorganic compounds. The emulsion has gas transport, anti-shock, plasma-substituting, cardioprotective and detoxification effects.

The gas transport function of the drug is related to its ability to carry carbon dioxide and oxygen. Due to the large gas exchange surface, the diffusion of oxygen, supplying ischemic tissues and organs, is significantly increased.

Perftoran blocks calcium channels. Proxanol, acting as a stabilizer in the emulsion, improves peripheral microcirculation and rheological properties of blood by reducing platelet aggregation and reducing blood viscosity.

Pharmacokinetics

Perftoran is chemically inert. It accumulates in the liver, reticuloendothelial system, and bone marrow. It is not metabolized in the body. It is excreted through the lungs and skin within 20-24 months.

Indications for use

• Acute and chronic hypovolemia (in the operational and postoperative period, with infectious-toxic, hemorrhagic, traumatic and burn shock, traumatic brain injury);
• Peripheral circulation and microcirculation disorders (with changes in gas exchange and tissue metabolism, infections, fat embolism, cerebrovascular accidents, purulent-septic conditions);
• Lavage of the lungs, regional perfusion, washing of purulent wounds of the abdominal and other cavities;
• Anti-ischemic protection of donor organs (preliminary preparation of the recipient and the donor).

Contraindications

The only strict contraindication to the use of Perftoran is hemophilia.

With caution and only for health reasons, the drug is used during pregnancy and lactation.

Instructions for the use of Perftoran: method and dosage

Before the infusion of the drug, the doctor conducts a visual examination of the emulsion and bottle. The emulsion is considered suitable for use, provided that the tightness of the closure is maintained, there are no cracks on the bottle and the label is intact. The result of the visual examination and the data indicated on the label (name of the medicinal product, manufacturer and batch number) are recorded in the medical history.

Before starting treatment, a biological test must be carried out: 5 drops of the emulsion are slowly injected to the patient, then a 3-minute break is taken, after which another 30 drops are injected and again take a break for 3 minutes. If negative reactions do not occur, the administration is continued. The results of the biological sample are also recorded in the medical history.

Recommended schemes for using Perftoran:

• Microcirculation disorders regardless of genesis: 5-8 ml / kg. If necessary, the drug is administered in the same dose 3 times with 2-4 day intervals. To increase the oxygenation effect, it is recommended to supply an oxygen-enriched air mixture (through a mask or nasal catheter);
• Acute blood loss, shock: at a dose of 5-30 ml / kg intravenous drip or stream. It is possible to get the maximum effect from the drug in cases when the patient breathes an oxygen-rich mixture - directly during the infusion and within 24 hours after it;
• Anti-ischemic protection of donor organs: at a dose of 20 ml / kg intravenous stream or drip to both the recipient and the donor 2 hours before the operation;
• Topical application: according to a scheme similar to the use of traditional drug therapy;
• Regional application (limb perfusion): 40 ml / kg when filling a standard oxygenator.

Side effects

Possible pain behind the breastbone and in the lumbar region, allergic reactions (itching, urticaria and redness of the skin), anaphylactoid reactions, difficulty breathing, increased heart rate, headache, fever, lowering blood pressure.

Overdose

Overdose cases have not been registered.

special instructions

Perftoran is intended for hospital use only.

The drug should not be used if, after defrosting, a white precipitate appears on the bottom of the bottle or the emulsion stratifies (transparent oily drops are visible, settling to the bottom even after shaking).

It is prohibited:

• Store the drug at temperatures below -18 ºС;
• Defrost at a temperature over 30 ºС;
• Shake the defrosted emulsion vigorously.

In case of side effects or complications, it is necessary to immediately stop the administration of Perftoran and, without removing the needle from the vein, depending on the general clinical picture, introduce glucocorticosteroid, cardiotonic, vasopressor, desensitizing or other drugs intended for the treatment of anaphylactic shock.

Defrost Perftoran at room temperature, then shake gently until the composition is homogeneous. Before infusion, the emulsion must be warmed to a temperature of 21-23 ºС.

Application during pregnancy and lactation

For pregnant and lactating women, the drug is prescribed exclusively for health reasons.

Drug interactions

According to the instructions, it is forbidden to use Perftoran together (in one heart-lung machine, one system or syringe) with hydroxyethyl starch, dextrans, rheopolyglucin, polyglucin. If necessary, the simultaneous use with the indicated means, they should be injected into another vein or into the same one, but after the end of the Perftoran infusion.

Analogs

There is no information about Perfotran analogues.

Terms and conditions of storage

Store at temperatures from -4 to -18 ºС (frozen).

The shelf life is 3 years.

It is also possible to temporarily store the drug in thawed form - at a temperature of 4 ºС for no more than 2 weeks.

Defrost / freeze 5 times allowed.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Perftoran

Despite the fact that the drug has been used in medicine for over 20 years, there are still discussions about its effectiveness and harm. Perftoran is an artificial emulsion and has a number of side effects, so doctors prefer donated blood whenever possible. A significant disadvantage of the drug is the ability of perfluorocarbon molecules to accumulate in the liver and cause accumulation diseases. It is for this reason that perfluorocarbon preparations are banned in the United States.

Currently, Perftoran is produced in limited quantities and is used, as a rule, locally in dermatological, cosmetological and gynecological practice (to prepare sperm for intrauterine insemination). Most often, you can find positive reviews about Perftoran when it is used in the listed areas of medicine.

Price for Perftoran in pharmacies

The price for Perftoran is 3000–3800 rubles per 100 ml bottle. The drug is intended only for use in a hospital or specialized center.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!