Triamcinolone - Instructions For Use, Indications, Doses

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Triamcinolone

Instructions for use:

1. 1. Pharmacological action
2. 2. Release form
3. 3. Indications for use
4. 4. Contraindications
5. 5. Instructions for use
6. 6. Side effects
7. 7. Special instructions
8. 8. Storage conditions

Triamcinolone is a hormonal drug of the glucocorticosteroid group.

Pharmacological action of Triamcinolone

Triamcinolone is used as an anti-allergic, immunosuppressive, anti-inflammatory and glucocorticoid agent. The therapeutic effect of taking Triamcinolone is achieved due to the property of suppressing tissue macrophages, leukocytes, fibroblasts and collagen formation. The action of the drug is aimed at limiting the migration of leukocytes to the area of inflammation and impairing the ability of macrophages to phagocytosis. In addition, Triamcinolone stabilizes lysosomal membranes, which entails a decrease in the concentration of proteolytic enzymes in the inflamed area of the body.

Trimacinolone has a stimulating effect on gluconeogenesis, increasing the activity of the enzymes involved in it. In addition, it acts as a catalyst in muscles, bone tissue, skin, connective and lymphoid tissues, adipose tissue.

Release form

Triamcinolone is available as 4 mg tablets; 0.1% ointment and cream weighing 5 or 10 g.

Indications for the use of Triamcinolone

The instruction for Triamcinolone recommends various forms of the drug, depending on the specific disease.

• The tablets should be taken in cases such as rheumatoid arthritis and rheumatism, collagenoses (including systemic lupus erythematosus), acute allergic reactions, skin diseases caused by allergies, severe bronchial asthma, hemolytic anemia, hemorrhagic diathesis, erythema multiforme, leukemias and lymphomas;
• Triamcinolone in the form of inhalation should be used for bronchial asthma in the acute phase, allergic rhinitis, hormone-dependent asthma;
• Parenteral administration of Triamcinolone is possible with rheumatoid arthritis, connective tissue diseases, dermatoses, systemic lupus erythematosus, emphysema or pulmonary fibrosis, lymphosarcoma, lymphatic leukemia, lymphogranulomatosis, nephrotic syndrome;
• External use of Triamcinolone is recommended for eczema, psoriasis, neurodermatitis, dermatitis of various types, as well as for other allergic and inflammatory skin diseases of non-microbial etiology as an integral part of complex therapy.

Contraindications

Triamcinolone is not recommended for patients with the following diseases:

• history of acute psychoses;
• active tuberculosis;
• myasthenia gravis;
• diverticulitis;
• neoplasms with metastases;
• peptic ulcer of the duodenum and / or stomach;
• arterial hypertension;
• renal failure;
• Itsenko-Cushing's syndrome;
• postponed thrombosis and embolism;
• osteoporosis;
• amyloidosis;
• diabetes;
• hidden foci of infection;
• fungal and viral infections (including herpes);
• poliomyelitis (except bulbar-encephalitis form);
• arthritis (gonococcal and tuberculous);
• glaucoma;
• lymphadenitis after BCG;
• skin infections.

Instructions for the use of Triamcinolone

According to the instructions for Triamcinolone, the drug should be taken in the dosages indicated below.

• Inside, adults are recommended from 4 to 20 mg of the drug per day, the frequency of administration is 2-3 times. When the condition improves, the daily dose of Triamcinolone is reduced to 2 mg, which must be taken every 2-3 days. Subsequently, the dose is reduced to a maintenance dose: 1 mg per day, then - the complete cancellation of therapy;
• with i / m administration of Triamcinolone, the dosage is 40 mg once every 4 weeks. Subsequently, focusing on the doctor's indications and the patient's tolerance of the drug, the dosage can be increased up to 80 mg every 2-4 weeks. If necessary, the dose can be increased to 100 mg. The drug should be injected deep into the muscle to avoid subcutaneous atrophy;
• the dosage of Triamcinolone for intra-articular injection or injection into the area of the lesion is from 10 to 40 mg every week;
• the dosage for inhalation with the drug is calculated based on the age of the patient and the form of Triamcinolone selected for the procedure;
• the frequency of using Triamcinolone for external use should not exceed three times a day. The duration of treatment, as a rule, does not exceed 10 days and is determined individually. In rare cases, the course of treatment is extended to 25 days, but it is not recommended to use the drug for more than 4 weeks.

Side effects of Triamcinolone

Before you start taking Triamcinolone, it is recommended to read the list of side effects in order to avoid complications in the future. In some cases, the use of Triamcinolone is accompanied by:

• violation of the menstrual cycle, redistribution of adipose tissue, increased blood glucose levels, suppression of adrenal function, the appearance of a "moon face". Striae, acne, hirsutism may also occur;
• edema, electrolyte imbalance, negative nitrogen balance, growth retardation in children;
• steroid stomach ulcer, acute pancreatitis, erosive and ulcerative lesions of the gastrointestinal tract;
• convulsions, sleep disorders and mental disorders, headaches, weakness;
• myopathy and osteoporosis;
• arterial hypertension;
• thromboembolism;
• visual impairment, posterior subcapsular cataract, increased intraocular pressure;
• anaphylactic reactions;
• exacerbation of infectious diseases.

In addition, there are specific side effects for each of the ways Triamcinolone is used:

• intra-articular injection may cause the appearance of joint pain, irritation at the injection site, sterile abscess, depigmentation, skin atrophy;
• when inhaled, side effects are possible such as sneezing, coughing, headache, dryness of the membranes of the nasal cavities or mouth, hoarseness, the appearance of a fungal infection such as Candida albicans;
• external use of the drug can cause itching, eczema, skin irritation, purpura and steroid acne. Long-term use of the ointment is fraught with the development of atrophic skin changes and secondary infectious signs.

special instructions

It should be borne in mind that Triamcinolone is not intended for intravenous administration.

Parenteral use in children aged 6 years or less is not recommended. For children from 6 to 12 years old, this method of using the drug should be prescribed in extreme cases.

Storage conditions

Triamcinolone should be stored away from light.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!